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Depressive Symptoms in Different Ranges of TSH in Patients with Subclinical Hypothyroidism
Corresponding Author(s) : Satkarjit Kaur Jhandi
International Journal of Allied Medical Sciences and Clinical Research,
Vol. 14 No. 3 (2026): 2026 Volume -14 - Issue 3
Abstract
Objectives: Depressive symptoms are a prevalent issue associated with subclinical hypothyroidism (SCH). Despite receiving levothyroxine (LT-4), many patients continue to exhibit neuropsychological symptoms even after achieving a euthyroid state (<4.0 mIU/L). The aim of this study was to evaluate the association between thyroid stimulating hormone (TSH) levels and depressive symptoms in SCH in different TSH ranges.
Methods: 144 participants were recruited and biochemical measurements done for thyroid profile and they were divided into four groups: 1) Individuals with no history of thyroid issues (TSH < 2.5mIU/L), 2) Newly diagnosed patients (TSH range ≥2.5mIU/L); 3) Patients with TSH levels ≥4.0mIU/L (ongoing LT-4), 4) Euthyroids with TSH levels <4.0mIU/L (ongoing LT-4). Depressive symptoms were evaluated with Hamilton depression rating scale.
Results: A positive association with a significant value (p = 0.009) was found in Group 2, with a correlation coefficient value of r = 0.43.
Conclusion: The present study concluded that early and regular screening for hypothyroidism appears warranted for patients stating neuropsychological complaints. Patients with SCH presenting with distressing neuropsychological symptoms (especially depressive symptoms), clinicians may possibly consider the initiation of LT4 at a TSH level of ≥ 2.5 mIU/L.