Formulation and Evaluation of Oral Dissolving Film Using Phyllanthus Amarus

Abstract

Jaundice is a clinical condition characterized by elevated bilirubin levels, leading to yellow discoloration of skin and mucous membranes. Herbal remedies have gained significant importance due to their safety and therapeutic efficacy. Phyllanthus amarus, a medicinal plant widely used in traditional medicine, possesses hepatoprotective, antiviral, and antioxidant properties. The present study aims to develop and evaluate a fast dissolving oral film (ODF) containing methanolic extract of Phyllanthus amarus. Fast dissolving films are novel drug delivery systems that dissolve rapidly in the oral cavity without the need for water, improving patient compliance, especially in pediatric and geriatric populations. The films were prepared using the solvent casting method with suitable polymers such as HPMC, along with plasticizers, sweeteners, and flavoring agents.

The formulated films were evaluated for parameters including thickness, weight variation, folding endurance, disintegration time, and drug content uniformity. The results demonstrated rapid disintegration, good mechanical strength, and uniform drug distribution. Thus, Phyllanthus amarus oral films offer a promising herbal drug delivery system with improved bioavailability and patient acceptability.