A Comparative and Synergistic study of Ficus religiosa and Lantana camara plant extracts on Antibacterial activity against Gram+ve and Gram-ve bacteria.

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Vol. 13 No. 3 (2025): 2025 Volume -13 - Issue 3

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August 16, 2025
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A Comparative and Synergistic study of Ficus religiosa and Lantana camara plant extracts on Antibacterial activity against Gram+ve and Gram-ve bacteria.

Rakam Gopi Krishna
Department of Pharmaceutical Chemistry, Marri Laxman Reddy Institute of Pharmacy, Dundigal (V&M), Hyderabad, Telangana, India-500043.
V.A.N.V. Harita
Department of Pharmaceutical Chemistry, Marri Laxman Reddy Institute of Pharmacy, Dundigal (V&M), Hyderabad, Telangana, India-500043.
V.V. Sridevi
Department of Pharmaceutics, Marri Laxman Reddy Institute of Pharmacy, Dundigal (V&M), Hyderabad, Telangana, India-500043.
K. Harini
Department of Pharmaceutical Chemistry, Marri Laxman Reddy Institute of Pharmacy, Dundigal (V&M), Hyderabad, Telangana, India-500043.
K. Pranay
Department of Pharmaceutical Chemistry, Marri Laxman Reddy Institute of Pharmacy, Dundigal (V&M), Hyderabad, Telangana, India-500043.
M. Rajesh
Department of Pharmaceutical Chemistry, Marri Laxman Reddy Institute of Pharmacy, Dundigal (V&M), Hyderabad, Telangana, India-500043.
M. Bharath
Department of Pharmaceutical Chemistry, Marri Laxman Reddy Institute of Pharmacy, Dundigal (V&M), Hyderabad, Telangana, India-500043.

Corresponding Author(s) : Rakam Gopi Krishna

gopirakam@gmail.com

International Journal of Allied Medical Sciences and Clinical Research, Vol. 13 No. 3 (2025): 2025 Volume -13 - Issue 3

Abstract

This study investigates the comparative and synergistic antibacterial activity of Ficus religiosa and Lantana camara plant extracts against two clinically significant bacterial strains: Escherichia coli (Gram-negative) and Staphylococcus aureus (Gram-positive). Both plants are traditionally used in herbal medicine and are known to possess bioactive compounds such as flavonoids, tannins, alkaloids, and essential oils with documented antimicrobial properties. Methanolic and aqueous extracts of the leaves and bark (for Ficus religiosa) and leaves and flowers (for Lantana camara) were prepared using standard extraction methods. Antibacterial activity was assessed using the agar well diffusion method, and the zone of inhibition was measured to evaluate efficacy. Results indicated that both plants exhibited significant antibacterial effects individually, with Ficus religiosa showing stronger activity against Staphylococcus aureus and Lantana camara demonstrating notable inhibition against E. coli. Interestingly, when used in combination, the extracts exhibited a synergistic effect, resulting in enhanced antibacterial activity against both pathogens. These findings suggest the potential of these plant extracts, particularly in combination, as natural antibacterial agents and support further investigation for possible use in developing herbal-based antimicrobial formulations.

Keywords

Antibacterial activity Escherichia coli Ficus religiosa Lantana camara Medicinal plants Phytochemicals Plant extracts Synergistic effect
1.
Rakam Gopi Krishna, V.A.N.V. Harita, V.V. Sridevi, K. Harini, K. Pranay, M. Rajesh, et al. A Comparative and Synergistic study of Ficus religiosa and Lantana camara plant extracts on Antibacterial activity against Gram+ve and Gram-ve bacteria. Int. J. of Allied Med. Sci. and Clin. Res. [Internet]. 2025 Aug. 16 [cited 2025 Sep. 20];13(3):494-506. Available from: https://ijamscr.com/ijamscr/article/view/1656
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