Comparative studies on pre-operative inj carboprost with misoprostol tablets in 12-15 weeks medical termination of pregnancies
Corresponding Author(s) : Mary Jayasheela
ijamscr@gmail.com
International Journal of Allied Medical Sciences and Clinical Research,
Vol. 3 No. 2 (2015): 2015 Volume 3- Issue -2
Abstract
Introduction
Induced abortions have earned much popularity in the last few years because of their greater safety and large impact on population control and on untimely or unwanted pregnancy. As many women, due to the lack of awareness, come in the late pregnancy i.e. later first trimester and early second trimester for termination, it becomes difficult to terminate by this method. Carboprost Inj and Misoprostol, are very safe and effective cervical softening agents with low cost, stability in light and climatic variations before the termination of pregnancy.
Materials and Methods: A prospective study using single intra muscular injection of carboprost and misoprostol tablets were administered to 100 patients each and were analysed according to the age, parity, gestational age, extent of cervical dilation achieved, procedure time, amount of blood loss and the complications.
Results and Discussion: Nearly 30% of the patients were between 25 – 34 of age, 88% were married and around 59% were of Parity 1 or 2. Vomiting was the most common type of complication in Group A and highest blood loss was seen among the 14th week of gestation patients in both groups.
Conclusion
Manual evacuation of MTP has always resulted in very good results in early pregnancies but in late pregnancies, the use of Carboprost Inj or Misoprostol is more effective and safe with equally good results
Keywords
Protaglandins
Carboprost Inj
Misoprostol Tablets
Medical Termination
Pregnancy
1.
Mary Jayasheela. Comparative studies on pre-operative inj carboprost with misoprostol tablets in 12-15 weeks medical termination of pregnancies. Int. J. of Allied Med. Sci. and Clin. Res. [Internet]. 2020 Aug. 4 [cited 2025 Nov. 6];3(2):218-23. Available from: https://ijamscr.com/ijamscr/article/view/164
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References
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[1]. Tenore JL. Methods for cervical ripening and induction of labor. Am Family Physician.2003; 67(10):2123–8.
[2]. Briggs GG, Wan SR. Drug therapy during labor and delivery, Part 2. Am J Health-Syst Pharm.2006; 63(12):131–9.
[3]. Carbonell Esteve JL, Mari JM, Valero F, Llorente M, Salvador I, Varela M, et al. Sublingual versus vaginal misoprostol (400microg) for cervical priming in first-trimester abortion: a randomized trial.Contraception. 2006 Oct; 74(4):328–33.
[4]. Prachasilpchai N, Russameecharoen K, Borriboonhirunsarn D. Success rate of second-trimester termination of pregnancy using misoprostol. J Med Assoc Thai. 2006 Aug; 89(8):1115–1119.
[5]. Cheng L. (1 November 2008). "Surgical versus medical methods for second-trimester induced abortion". The WHO Reproductive Health Library. World Health Organization.Archived from the original on 17 June 2011. Retrieved 17 June 2011.
[6]. Bankole et al. (1998). "Reasons Why Women Have Induced Abortions: Evidence from 27 Countries". International Family Planning Perspectives 24 (3): 117–127 & 152.
[7]. Lohr, P. A.; Fjerstad, M.; Desilva, U.; Lyus, R. (2014). "Abortion". BMJ 348: f7553.
[8]. Sedgh, G.; Singh, S.; Shah, I. H.; Åhman, E.; Henshaw, S. K.; Bankole, A. (2012). "Induced abortion: Incidence and trends worldwide from 1995 to 2008" (PDF).The Lancet 379 (9816): 625–632.
[9]. Sedgh G, Henshaw SK, Singh S, Bankole A, Drescher J (September 2007). "Legal abortion worldwide: incidence and recent trends". Int Fam Plan Perspect 33 (3): 106–116.
[10]. Grimes, D. A.; Benson, J.; Singh, S.; Romero, M.; Ganatra, B.; Okonofua, F. E.; Shah, I. H. (2006). "Unsafe abortion: The preventable pandemic" (PDF). The Lancet368 (9550): 1908–1919.
[11]. Raymond, EG; Grossman, D; Weaver, MA; Toti, S; Winikoff, B (Nov 2014). "Mortality of induced abortion, other outpatient surgical procedures and common activities in the United States.". Contraception 90 (5): 476-479.
[12]. Organization, World Health (2012). Safe abortion: technical and policy guidance for health systems (PDF) (2nd ed. ed.). Geneva: World Health Organization. p. 8.
[13]. Shah, I.; Ahman, E. (December 2009). "Unsafe abortion: global and regional incidence, trends, consequences, and challenges" (PDF). Journal of Obstetrics and Gynaecology Canada 31 (12): 1149–58.
[14]. Chandrasekhar, S. India's Abortion Experience Denton, TX: University of North Texas Press, 1994.
[15]. "Medical Termination of Pregnancy, 1971". Medindia.com. Retrieved 10 December 2008.
[16]. Kulier, R; Kapp, N; Gülmezoglu, AM; Hofmeyr, GJ; Cheng, L; Campana, A (Nov 9, 2011). "Medical methods for first trimester abortion.” The Cochrane database of systematic reviews (11): CD002855.
[17]. Jump up to:a b c Kapp, N; Whyte, P; Tang, J; Jackson, E; Brahmi, D (Sep 2013). "A review of evidence for safe abortion care.". Contraception 88 (3): 350–63.
[18]. Krofta L1, Calda P, Zizka Z, Parízek A, Hrusková H, Kapras J. Termination of pregnancy in the 2nd trimester using intra-amniotic administration of prostaglandins. Ceska Gynekol. 1998 Oct;63(5):414-7
[19]. Fait T1, Calda P, Zizka Z, Pavlista D, Hrusková H, Zivný J. Termination of 128 pregnancies in the 2nd trimester using prostaglandin 15 methyl F2 alpha.. Ceska Gynekol. 2000 Nov;65(6):451-5.
[20]. Banerjee Alok, Anand Abhijit, Elul Batya, Kalyanwala shveta. Mifepristone and misoprostol abortion in free standing Reproductive health clinics in India. J Obstet Gynecol India, .2009 Vol 59(5); 432-439.
[21]. Shetty Jyothi, MNV Pallavi. Medical abortion by Mifepristone with oral versus vaginal misoprostol. J obstet Gynecol India; 2006, 56(6); 529- 531.
[22]. Mundle Shuchita, Kalyanwala shveta, Elul Batya, Ughade Suresh. : Simplifying medical abortion: home administration of misoprostol:.J obstat Gynecol India ;2008, 58 (5): 410-416.
[23]. Rita G Nayak1, Yamini S Patil Sanjaykumar Patil3, Nitin Kshirsagar. A comparison of manual vacuum aspiration with medical method of abortion in termination of pregnancy up to 9 weeks of gestational age. International Journal of Recent Trends in Science And Technology, 2015;13(3): pp 490-494
[24]. Nasira Tasnim, Ghazala Mahmud,Saba Fatima,Mohsina sultana. Manual vacuum aspiration: a safe and cost effective substitute of Electric vacuum aspiration for the surgical management of early pregnancy loss.Maternal and child Health Center, Pakistan Institute of Medical Sciences. Feb 2011, vol. 61.no 2.pg 149-153.
References
[1]. Tenore JL. Methods for cervical ripening and induction of labor. Am Family Physician.2003; 67(10):2123–8.
[2]. Briggs GG, Wan SR. Drug therapy during labor and delivery, Part 2. Am J Health-Syst Pharm.2006; 63(12):131–9.
[3]. Carbonell Esteve JL, Mari JM, Valero F, Llorente M, Salvador I, Varela M, et al. Sublingual versus vaginal misoprostol (400microg) for cervical priming in first-trimester abortion: a randomized trial.Contraception. 2006 Oct; 74(4):328–33.
[4]. Prachasilpchai N, Russameecharoen K, Borriboonhirunsarn D. Success rate of second-trimester termination of pregnancy using misoprostol. J Med Assoc Thai. 2006 Aug; 89(8):1115–1119.
[5]. Cheng L. (1 November 2008). "Surgical versus medical methods for second-trimester induced abortion". The WHO Reproductive Health Library. World Health Organization.Archived from the original on 17 June 2011. Retrieved 17 June 2011.
[6]. Bankole et al. (1998). "Reasons Why Women Have Induced Abortions: Evidence from 27 Countries". International Family Planning Perspectives 24 (3): 117–127 & 152.
[7]. Lohr, P. A.; Fjerstad, M.; Desilva, U.; Lyus, R. (2014). "Abortion". BMJ 348: f7553.
[8]. Sedgh, G.; Singh, S.; Shah, I. H.; Åhman, E.; Henshaw, S. K.; Bankole, A. (2012). "Induced abortion: Incidence and trends worldwide from 1995 to 2008" (PDF).The Lancet 379 (9816): 625–632.
[9]. Sedgh G, Henshaw SK, Singh S, Bankole A, Drescher J (September 2007). "Legal abortion worldwide: incidence and recent trends". Int Fam Plan Perspect 33 (3): 106–116.
[10]. Grimes, D. A.; Benson, J.; Singh, S.; Romero, M.; Ganatra, B.; Okonofua, F. E.; Shah, I. H. (2006). "Unsafe abortion: The preventable pandemic" (PDF). The Lancet368 (9550): 1908–1919.
[11]. Raymond, EG; Grossman, D; Weaver, MA; Toti, S; Winikoff, B (Nov 2014). "Mortality of induced abortion, other outpatient surgical procedures and common activities in the United States.". Contraception 90 (5): 476-479.
[12]. Organization, World Health (2012). Safe abortion: technical and policy guidance for health systems (PDF) (2nd ed. ed.). Geneva: World Health Organization. p. 8.
[13]. Shah, I.; Ahman, E. (December 2009). "Unsafe abortion: global and regional incidence, trends, consequences, and challenges" (PDF). Journal of Obstetrics and Gynaecology Canada 31 (12): 1149–58.
[14]. Chandrasekhar, S. India's Abortion Experience Denton, TX: University of North Texas Press, 1994.
[15]. "Medical Termination of Pregnancy, 1971". Medindia.com. Retrieved 10 December 2008.
[16]. Kulier, R; Kapp, N; Gülmezoglu, AM; Hofmeyr, GJ; Cheng, L; Campana, A (Nov 9, 2011). "Medical methods for first trimester abortion.” The Cochrane database of systematic reviews (11): CD002855.
[17]. Jump up to:a b c Kapp, N; Whyte, P; Tang, J; Jackson, E; Brahmi, D (Sep 2013). "A review of evidence for safe abortion care.". Contraception 88 (3): 350–63.
[18]. Krofta L1, Calda P, Zizka Z, Parízek A, Hrusková H, Kapras J. Termination of pregnancy in the 2nd trimester using intra-amniotic administration of prostaglandins. Ceska Gynekol. 1998 Oct;63(5):414-7
[19]. Fait T1, Calda P, Zizka Z, Pavlista D, Hrusková H, Zivný J. Termination of 128 pregnancies in the 2nd trimester using prostaglandin 15 methyl F2 alpha.. Ceska Gynekol. 2000 Nov;65(6):451-5.
[20]. Banerjee Alok, Anand Abhijit, Elul Batya, Kalyanwala shveta. Mifepristone and misoprostol abortion in free standing Reproductive health clinics in India. J Obstet Gynecol India, .2009 Vol 59(5); 432-439.
[21]. Shetty Jyothi, MNV Pallavi. Medical abortion by Mifepristone with oral versus vaginal misoprostol. J obstet Gynecol India; 2006, 56(6); 529- 531.
[22]. Mundle Shuchita, Kalyanwala shveta, Elul Batya, Ughade Suresh. : Simplifying medical abortion: home administration of misoprostol:.J obstat Gynecol India ;2008, 58 (5): 410-416.
[23]. Rita G Nayak1, Yamini S Patil Sanjaykumar Patil3, Nitin Kshirsagar. A comparison of manual vacuum aspiration with medical method of abortion in termination of pregnancy up to 9 weeks of gestational age. International Journal of Recent Trends in Science And Technology, 2015;13(3): pp 490-494
[24]. Nasira Tasnim, Ghazala Mahmud,Saba Fatima,Mohsina sultana. Manual vacuum aspiration: a safe and cost effective substitute of Electric vacuum aspiration for the surgical management of early pregnancy loss.Maternal and child Health Center, Pakistan Institute of Medical Sciences. Feb 2011, vol. 61.no 2.pg 149-153.
[2]. Briggs GG, Wan SR. Drug therapy during labor and delivery, Part 2. Am J Health-Syst Pharm.2006; 63(12):131–9.
[3]. Carbonell Esteve JL, Mari JM, Valero F, Llorente M, Salvador I, Varela M, et al. Sublingual versus vaginal misoprostol (400microg) for cervical priming in first-trimester abortion: a randomized trial.Contraception. 2006 Oct; 74(4):328–33.
[4]. Prachasilpchai N, Russameecharoen K, Borriboonhirunsarn D. Success rate of second-trimester termination of pregnancy using misoprostol. J Med Assoc Thai. 2006 Aug; 89(8):1115–1119.
[5]. Cheng L. (1 November 2008). "Surgical versus medical methods for second-trimester induced abortion". The WHO Reproductive Health Library. World Health Organization.Archived from the original on 17 June 2011. Retrieved 17 June 2011.
[6]. Bankole et al. (1998). "Reasons Why Women Have Induced Abortions: Evidence from 27 Countries". International Family Planning Perspectives 24 (3): 117–127 & 152.
[7]. Lohr, P. A.; Fjerstad, M.; Desilva, U.; Lyus, R. (2014). "Abortion". BMJ 348: f7553.
[8]. Sedgh, G.; Singh, S.; Shah, I. H.; Åhman, E.; Henshaw, S. K.; Bankole, A. (2012). "Induced abortion: Incidence and trends worldwide from 1995 to 2008" (PDF).The Lancet 379 (9816): 625–632.
[9]. Sedgh G, Henshaw SK, Singh S, Bankole A, Drescher J (September 2007). "Legal abortion worldwide: incidence and recent trends". Int Fam Plan Perspect 33 (3): 106–116.
[10]. Grimes, D. A.; Benson, J.; Singh, S.; Romero, M.; Ganatra, B.; Okonofua, F. E.; Shah, I. H. (2006). "Unsafe abortion: The preventable pandemic" (PDF). The Lancet368 (9550): 1908–1919.
[11]. Raymond, EG; Grossman, D; Weaver, MA; Toti, S; Winikoff, B (Nov 2014). "Mortality of induced abortion, other outpatient surgical procedures and common activities in the United States.". Contraception 90 (5): 476-479.
[12]. Organization, World Health (2012). Safe abortion: technical and policy guidance for health systems (PDF) (2nd ed. ed.). Geneva: World Health Organization. p. 8.
[13]. Shah, I.; Ahman, E. (December 2009). "Unsafe abortion: global and regional incidence, trends, consequences, and challenges" (PDF). Journal of Obstetrics and Gynaecology Canada 31 (12): 1149–58.
[14]. Chandrasekhar, S. India's Abortion Experience Denton, TX: University of North Texas Press, 1994.
[15]. "Medical Termination of Pregnancy, 1971". Medindia.com. Retrieved 10 December 2008.
[16]. Kulier, R; Kapp, N; Gülmezoglu, AM; Hofmeyr, GJ; Cheng, L; Campana, A (Nov 9, 2011). "Medical methods for first trimester abortion.” The Cochrane database of systematic reviews (11): CD002855.
[17]. Jump up to:a b c Kapp, N; Whyte, P; Tang, J; Jackson, E; Brahmi, D (Sep 2013). "A review of evidence for safe abortion care.". Contraception 88 (3): 350–63.
[18]. Krofta L1, Calda P, Zizka Z, Parízek A, Hrusková H, Kapras J. Termination of pregnancy in the 2nd trimester using intra-amniotic administration of prostaglandins. Ceska Gynekol. 1998 Oct;63(5):414-7
[19]. Fait T1, Calda P, Zizka Z, Pavlista D, Hrusková H, Zivný J. Termination of 128 pregnancies in the 2nd trimester using prostaglandin 15 methyl F2 alpha.. Ceska Gynekol. 2000 Nov;65(6):451-5.
[20]. Banerjee Alok, Anand Abhijit, Elul Batya, Kalyanwala shveta. Mifepristone and misoprostol abortion in free standing Reproductive health clinics in India. J Obstet Gynecol India, .2009 Vol 59(5); 432-439.
[21]. Shetty Jyothi, MNV Pallavi. Medical abortion by Mifepristone with oral versus vaginal misoprostol. J obstet Gynecol India; 2006, 56(6); 529- 531.
[22]. Mundle Shuchita, Kalyanwala shveta, Elul Batya, Ughade Suresh. : Simplifying medical abortion: home administration of misoprostol:.J obstat Gynecol India ;2008, 58 (5): 410-416.
[23]. Rita G Nayak1, Yamini S Patil Sanjaykumar Patil3, Nitin Kshirsagar. A comparison of manual vacuum aspiration with medical method of abortion in termination of pregnancy up to 9 weeks of gestational age. International Journal of Recent Trends in Science And Technology, 2015;13(3): pp 490-494
[24]. Nasira Tasnim, Ghazala Mahmud,Saba Fatima,Mohsina sultana. Manual vacuum aspiration: a safe and cost effective substitute of Electric vacuum aspiration for the surgical management of early pregnancy loss.Maternal and child Health Center, Pakistan Institute of Medical Sciences. Feb 2011, vol. 61.no 2.pg 149-153.