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Vol. 13 No. 2 (2025): 2025 Volume -13 - Issue 2

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Submitted
April 21, 2025
Published
April 21, 2025
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A Review on Antidiabetic Activity of Orientin

https://doi.org/10.61096/ijamscr.v13.iss2.2025.173-179
Kuchi Manjeera
Assistant Professor, Department of Pharmacology, C.M.R. College of Pharmacy, Kandlakoya, Medchal, Hyderabad, Telangana, India-501401
Vattepally Anusha
Assistant Professor, Department of Pharmacology, C.M.R. College of Pharmacy, Kandlakoya, Medchal, Hyderabad, Telangana, India-501401
V.V. Rajesham
Department of Pharmacology, CMR College of Pharmacy Kandlakoya (v), Medchal road, Hyderabad, Telangana, 501401, India.
T. Rama Rao
Department of Pharmacology, CMR College of Pharmacy Kandlakoya (v), Medchal road, Hyderabad, Telangana, 501401, India.

Corresponding Author(s) : Kuchi Manjeera

mkuchi@gitam.in

International Journal of Allied Medical Sciences and Clinical Research, Vol. 13 No. 2 (2025): 2025 Volume -13 - Issue 2

Abstract

Diabetes mellitus is a long-term metabolic condition characterized by increased blood sugar levels caused by insulin resistance, reduced insulin secretion or both. Even while synthetic antidiabetic medications are readily available, their prolonged use is linked to adverse effects, which makes the search for natural alternatives necessary. Orientin, a bioactive flavonoid glycoside that is mostly present in Phyllostachys nigra (black bamboo leaves), Passiflora incarnata (passionflower), and Ocimum sanctum (holy basil), has drawn a lot of interest due to its possible antidiabetic effects. This review examines the pharmacological processes that underlie orientin's antidiabetic actions, such as its capacity to improve glucose absorption, control insulin signaling pathways, and alter oxidative stress. Studies have demonstrated that orientin increases GLUT4 translocation, inhibits AMP-activated protein kinase (AMPK), and activates AMP to produce its hypoglycemic effects.

Keywords

Diabetes mellitus Phytochemicals Antidiabetic agents Adverse effects
1.
Kuchi Manjeera, Vattepally Anusha, V.V. Rajesham, T. Rama Rao. A Review on Antidiabetic Activity of Orientin. Int. J. of Allied Med. Sci. and Clin. Res. [Internet]. 2025 Apr. 21 [cited 2025 May 20];13(2):173-9. Available from: https://ijamscr.com/ijamscr/article/view/1607
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