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Formulation and Evaluation of Indomethacin Liposomes
Corresponding Author(s) : Ayesha Anjum
International Journal of Allied Medical Sciences and Clinical Research,
Vol. 12 No. 4 (2024): 2024 Volume -12 - Issue 4
Abstract
Indomethacin is a nonsteroidal anti-inflammatory drug (NSAID) commonly used as a prescription medication to reduce fever, pain, stiffness, and swelling from inflammation. The objective of the present study was to formulate and evaluate liposomes loaded with Indomethacin. Liposome of Indomethacin was made by thin film hydration method. Phospholipids and cholesterol were used to make multilamellar vesicles. Six batches of liposomes were prepared based on the different weight ratio of Phospholipids and cholesterol. Differential scanning calorimetry (DSC) study conducted to study in any incompatibility. Liposomes were produced by the thin-film hydration method. Six formulations of liposomes were prepared by varying the concentrations of Phospholipids and cholesterol and changing the drug ratio. The obtained liposomes were characterized for surface morphology, FTIR, particle size, zeta potential, drug content, entrapment efficiency, and in-vitro diffusion studies. Among the Six formulations of liposomes, F5 was found to be the best formulation with entrapment efficiency of 85.81% and a zeta potential value of -28.4mV. Liposomes followed Peppas release kinetics. Indomethacin loaded liposomes were prepared with good stability and the highest entrapment efficiency
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- Tariq Jamshaid. Pharmaceutics & novel drug delivery systems. Pharmaceutical regulatory affairs, 2015; 4(3):74.
- Naresh Kalra1 and G. Jeyabalan. Niosomes: a versatile drug delivery system. Research journal of life sciences, bioinformatics, pharmaceutical and chemical science, 2016; 2(4): 44-54.
- Nagashree Kotturi. Novel drug delivery system. Research & Reviews: Journal of Pharmaceutics and Nanotechnology, 2015; 3(2): 32-36.
- Shaktipal Patil, Amrapali Mhaiskar and Dharmendra Mundhada. A review on novel drug delivery system: a recent trend. International Journal of Current Pharmaceutical & Clinical Research, 2016; 6(2): 89-93.
- R.R. Bhagwat and I.S. Vaidhya. Novel drug delivery systems: An overview. International journal of pharmaceutical sciences and research, 2013; 4(3): 970-982.
- Kant shashi, Kumar satinder and Prashar bharath. A complete review on: Liposomes. International research journal of pharmacy, 2012; 3(7):10-16.
- Abolfazl Akbarzadeh, Rogaie Rezaei-Sadabady, Soodabeh Davaran, Sang Woo Joo, Nosratollah Zarghami,Younes Hanifehpour, Mohammad Samiei, Mohammad Kouhi and Kazem Nejati-Koshki. Liposome: classification, preparation, and applications. Nanoscale Research Letters, 2013; 8(102):1-9.
- S. Suggy Chrai, R. Murari, and Imran Ahmad. Liposomes: A Review. Biotech Trends, 2001; 14(11):10–14.
- W Andreas, Karola-Uhl. Liposome technology for industrial purposes. Journal of Drug Delivery; 2011:1-9.
- M Mansoori, S Agrawal, S Jawade, M. I. Khan. Review of Liposome. International Journal of Advanced Research Pharmaceutical and Bio Sciences, 2012; 2 (4):453-464.
- V.N.L Sirisha, I. BhavaniHarika, B. Sruthi, Namrata, P. Kirankumar, Y. Kiran Kumar Rao, K. Pranavi, S. Sindhura, N. Vamsi Krishna , O. UmaMaheshwaraRao. Liposomes – potential drug carriers. IOSR Journal of Pharmacy, 2012; 2(5): 26-38.
- Abdus Samad, Y. Sultana and M. Aqil. Liposomal drug delivery systems: An update review. Current drug delivery, 2007; 4(4): 297-305.
- R. Lipowsky and E. Sackmann. Applications of Liposomes, Handbook of Biological Physics. 1995; 1: 491-519.
- Vishal Kumar, Nethish Kumaar R, D Aswin, Sreeja C Nair. Propranolol HCL-loaded liposomes for intranasal delivery: in vitro and ex vivo evaluation of optimized formulation using design of experiments. Ther Deliv. 2023 Nov;14(11):705-720. doi: 10.4155/tde-2023-0044.
- Zingade Sarika G, Nagoba Shivappa N., Swami Avinash B, Vijayendra Swamy S. M. Formulation and Evaluation of Liposomes Containing Erlotinib Hydrochloride. Bulletin of Environment, Pharmacology and Life Sciences Bull. Env.Pharmacol. Life Sci., Vol 11[4] March 2022:01-08.
References
Tariq Jamshaid. Pharmaceutics & novel drug delivery systems. Pharmaceutical regulatory affairs, 2015; 4(3):74.
Naresh Kalra1 and G. Jeyabalan. Niosomes: a versatile drug delivery system. Research journal of life sciences, bioinformatics, pharmaceutical and chemical science, 2016; 2(4): 44-54.
Nagashree Kotturi. Novel drug delivery system. Research & Reviews: Journal of Pharmaceutics and Nanotechnology, 2015; 3(2): 32-36.
Shaktipal Patil, Amrapali Mhaiskar and Dharmendra Mundhada. A review on novel drug delivery system: a recent trend. International Journal of Current Pharmaceutical & Clinical Research, 2016; 6(2): 89-93.
R.R. Bhagwat and I.S. Vaidhya. Novel drug delivery systems: An overview. International journal of pharmaceutical sciences and research, 2013; 4(3): 970-982.
Kant shashi, Kumar satinder and Prashar bharath. A complete review on: Liposomes. International research journal of pharmacy, 2012; 3(7):10-16.
Abolfazl Akbarzadeh, Rogaie Rezaei-Sadabady, Soodabeh Davaran, Sang Woo Joo, Nosratollah Zarghami,Younes Hanifehpour, Mohammad Samiei, Mohammad Kouhi and Kazem Nejati-Koshki. Liposome: classification, preparation, and applications. Nanoscale Research Letters, 2013; 8(102):1-9.
S. Suggy Chrai, R. Murari, and Imran Ahmad. Liposomes: A Review. Biotech Trends, 2001; 14(11):10–14.
W Andreas, Karola-Uhl. Liposome technology for industrial purposes. Journal of Drug Delivery; 2011:1-9.
M Mansoori, S Agrawal, S Jawade, M. I. Khan. Review of Liposome. International Journal of Advanced Research Pharmaceutical and Bio Sciences, 2012; 2 (4):453-464.
V.N.L Sirisha, I. BhavaniHarika, B. Sruthi, Namrata, P. Kirankumar, Y. Kiran Kumar Rao, K. Pranavi, S. Sindhura, N. Vamsi Krishna , O. UmaMaheshwaraRao. Liposomes – potential drug carriers. IOSR Journal of Pharmacy, 2012; 2(5): 26-38.
Abdus Samad, Y. Sultana and M. Aqil. Liposomal drug delivery systems: An update review. Current drug delivery, 2007; 4(4): 297-305.
R. Lipowsky and E. Sackmann. Applications of Liposomes, Handbook of Biological Physics. 1995; 1: 491-519.
Vishal Kumar, Nethish Kumaar R, D Aswin, Sreeja C Nair. Propranolol HCL-loaded liposomes for intranasal delivery: in vitro and ex vivo evaluation of optimized formulation using design of experiments. Ther Deliv. 2023 Nov;14(11):705-720. doi: 10.4155/tde-2023-0044.
Zingade Sarika G, Nagoba Shivappa N., Swami Avinash B, Vijayendra Swamy S. M. Formulation and Evaluation of Liposomes Containing Erlotinib Hydrochloride. Bulletin of Environment, Pharmacology and Life Sciences Bull. Env.Pharmacol. Life Sci., Vol 11[4] March 2022:01-08.