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A Prospective Observational Study On The Quadruple Therapy Of Post Cabg And Ptca Patients In A Tertiary Care Hospital
International Journal of Allied Medical Sciences and Clinical Research,
Vol. 12 No. 2 (2024): 2024 Volume -12 - Issue 2
Abstract
This study presents a prospective observational study on the efficacy of quadruple therapy in post-percutaneous transluminal coronary angioplasty (PTCA) and coronary artery bypass grafting (CABG) patients at a tertiary care hospital. The study involved 250 patients and focused on evaluating the impact of comprehensive treatment involving dual antiplatelet therapy (DAPT), statins, beta-blockers, and ACE inhibitors/ARBs on the secondary prevention of cardiovascular events. The findings suggest that quadruple therapy is highly effective in reducing adverse cardiovascular outcomes and promoting recovery in post-revascularization patients. The study emphasizes the importance of comprehensive post-operative care, integrating medication management with lifestyle and dietary modifications to improve long-term health outcomes in patients with coronary artery disease (CAD).
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- Stone NJ, Robinson JG, Lichtenstein AH, et al. 2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: A report of the American College of Cardiology/American Heart Association Task Force on practice guidelines. Circulation. 2014;129(Suppl 2):S1-S45
- Baigent C, Blackwell L, Emberson J, et al. Efficacy and safety of more intensive lowering of LDL cholesterol: A meta-analysis of data from 170,000 participants in 26 randomised trials. Lancet. 2010; 376:1670-1681.
- Stone NJ, Robinson JG, Lichtenstein AH, et al. ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: A report of the American College of Cardiology/American Heart Association Task Force on practice guidelines. Circulation. 2014;129 (Suppl 2)-S45.
- Liu J, Ma J, Wang J, et al. Clinical outcomes of remote ischemic preconditioning prior to cardiac surgery: a meta-analysis of randomized controlled trials. J Am Heart Assoc. 2017;6
- Khan AR, Golwala H, Tripathi A, et al. Impact of total occlusions on 2-year outcomes in ST-elevation myocardial infarction patients undergoing PCI from the TOTAL trial. Circ Cardiovasc Interv. 2018;11
- Bansilal S, Castellano JM, Fuster V. Polypill for cardiovascular disease prevention in an underserved population. N Engl J Med. 2015; 373:1341-1351.
- O'Gara PT, Kushner FG, Ascheim DD, et al. 2013 ACCF/AHA guideline for the management of ST-elevation myocardial infarction: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol. 2013; 61-140.
- Amsterdam EA, Wenger NK, Brindis RG, et al. 2014 AHA/ACC guideline for the management of patients with non-ST-elevation acute coronary syndromes: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol. 2014; 64-228.
- Montalescot G, Sechtem U, Achenbach S, et al. 2013 ESC guidelines on the management of stable coronary artery disease: the Task Force on the management of stable coronary artery disease of the European Society of Cardiology. Eur Heart J. 2013;34:2949-3003.
- Jneid H, Addison D, Bhatt DL, et al. 2012 ACCF/AHA focused update of the guideline for the management of patients with unstable angina/Non-ST-elevation myocardial infarction (updating the 2007 guideline and replacing the 2011 focused update): a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Circulation. 2012; 126:875-910.
- Levine GN, Bates ER, Bittl JA, et al. 2016 ACC/AHA guideline focused update on duration of dual antiplatelet therapy in patients with coronary artery disease: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. J Am Coll Cardiol. 2016; 68:1082-1115.
References
Stone NJ, Robinson JG, Lichtenstein AH, et al. 2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: A report of the American College of Cardiology/American Heart Association Task Force on practice guidelines. Circulation. 2014;129(Suppl 2):S1-S45
Baigent C, Blackwell L, Emberson J, et al. Efficacy and safety of more intensive lowering of LDL cholesterol: A meta-analysis of data from 170,000 participants in 26 randomised trials. Lancet. 2010; 376:1670-1681.
Stone NJ, Robinson JG, Lichtenstein AH, et al. ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: A report of the American College of Cardiology/American Heart Association Task Force on practice guidelines. Circulation. 2014;129 (Suppl 2)-S45.
Liu J, Ma J, Wang J, et al. Clinical outcomes of remote ischemic preconditioning prior to cardiac surgery: a meta-analysis of randomized controlled trials. J Am Heart Assoc. 2017;6
Khan AR, Golwala H, Tripathi A, et al. Impact of total occlusions on 2-year outcomes in ST-elevation myocardial infarction patients undergoing PCI from the TOTAL trial. Circ Cardiovasc Interv. 2018;11
Bansilal S, Castellano JM, Fuster V. Polypill for cardiovascular disease prevention in an underserved population. N Engl J Med. 2015; 373:1341-1351.
O'Gara PT, Kushner FG, Ascheim DD, et al. 2013 ACCF/AHA guideline for the management of ST-elevation myocardial infarction: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol. 2013; 61-140.
Amsterdam EA, Wenger NK, Brindis RG, et al. 2014 AHA/ACC guideline for the management of patients with non-ST-elevation acute coronary syndromes: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol. 2014; 64-228.
Montalescot G, Sechtem U, Achenbach S, et al. 2013 ESC guidelines on the management of stable coronary artery disease: the Task Force on the management of stable coronary artery disease of the European Society of Cardiology. Eur Heart J. 2013;34:2949-3003.
Jneid H, Addison D, Bhatt DL, et al. 2012 ACCF/AHA focused update of the guideline for the management of patients with unstable angina/Non-ST-elevation myocardial infarction (updating the 2007 guideline and replacing the 2011 focused update): a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Circulation. 2012; 126:875-910.
Levine GN, Bates ER, Bittl JA, et al. 2016 ACC/AHA guideline focused update on duration of dual antiplatelet therapy in patients with coronary artery disease: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. J Am Coll Cardiol. 2016; 68:1082-1115.