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To Evaluate The Efficacy Of Homeopathic Medicines In Post Covid Syndrome With Emphasis On Dyspnea, Fatigue And Hairfall
Corresponding Author(s) : Bhanuja singh Jodha
International Journal of Allied Medical Sciences and Clinical Research,
Vol. 12 No. 2 (2024): 2024 Volume -12 - Issue 2
Abstract
Post-COVID syndrome is increasingly recognized as a new clinical entity in the context of SARS-CoV-2 infection. Symptoms persisting for more than three weeks after the diagnosis of COVID-19 characterize the post-COVID syndrome. Prolonged inflammation has a key role in its pathogenesis and may account for several symptoms. Long COVID is a term used to describe presence of various symptoms, even weeks or months after acquiring SARS-CoV-2 infection irrespective of the viral status. There can be the persistence of one or more symptoms of acute COVID, or appearance of new symptoms. Most people with post-COVID syndrome are PCR negative, indicating microbiological recovery.
To determine the efficacy of homoeopathic medicines in post covid syndrome with emphasis on Dyspnea, fatigue & hair fall.
Data analysis includes statistical methods to assess the significance of changes in symptom severity over the treatment period. Additionally, subgroup analyses may be conducted to explore variations in treatment response based on demographic factors and comorbidities.
Out of 100 cases 77 patients of 77 % were improved and 23 patients of 23 % were not improved. The paired t-test resulted in a statistical value of (15.94), indicating a p-value of less than (<0.05). This indicates that the study was statistically significant; supporting the hypothesis that homoeopathy can improve post-Covid symptoms (Fatigue, Dyspnea and Hair fall).
The findings of this study could contribute valuable insights into the potential role of homoeopathic medicines in managing post-COVID syndrome, providing a complementary and holistic approach to alleviate dyspnea, fatigue, and hair fall. This research may inform future clinical practices and contribute to a more comprehensive understanding of integrative approaches to post-viral sequelae
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- Sreehitha, Daliparthy Sai, and Justina M. Steefan. "Efficacy of homoeopathy in treating post-COVID fatigue in adults using fatigue assessment scale. IJHS. 2023;7(1):37-42. https://www.homoeopathicjournal.com/articles/729/7-1-9-845.pdf
- Kaur H, Bawaskar R, Khobragade A, Kalra D, Packiam V, Khan MY, Kaur T, Sharma M, Verma NK, Kaushik S, Khurana A. Randomised controlled trial to compare efficacy of standard care alone and in combination with homoeopathic treatment of moderate/severe COVID-19 cases. Plos one. 2023 Nov 15;18(11):e0292783. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0292783
- Dixit AK, Giri N, Singh S. Exploring the scope of homoeopathy in combating the unfortunate consequences of post-COVID-19 survivors based on non-COVID conditions: a narrative review. Journal of Complementary and Integrative Medicine. 2023 Jun 15;20(2):302-15. https://www.degruyter.com/document/doi/10.1515/jcim-2021-0200/html
- Chaudhary, Anupriya, and Anil Khurana. A review on the role of Homoeopathy in epidemics with some reflections on COVID‑19 (SARS‑CoV‑2). 2020. http://aohindia.in/jspui/handle/123456789/7482
- Nayak D, Devarajan K, Pal PP, Ponnam HB, Jain N, Shastri V, Bawaskar R, Chinta R, Khurana A, COVID-19 Study Group. Efficacy of Arsenicum album 30C in the Prevention of COVID-19 in Individuals Residing in Containment Areas: A Prospective, Multicenter, Cluster-Randomized, Parallel-Arm, Community-Based, Open-Label Study. Complementary Medicine Research. 2023 Nov 1;30(5):375-85. https://karger.com/cmr/article/30/5/375/836949
- Yadav M, Mangal G, Garg G. COVID-19-Understanding the emerging viral disease through the concepts of Ayurveda. Journal of Ayurveda. 2020 Oct 1;14(4):16-21. https://journals.lww.com/joay/fulltext/2020/14040/covid_19__understanding_the_emerging_viral_disease.5.aspx
- Townsend L, Moloney D, Finucane C, McCarthy K, Bergin C, Bannan C, Kenny RA. Fatigue following COVID-19 infection is not associated with autonomic dysfunction. PloS one. 2021 Feb 25;16(2):e0247280. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0247280
- Davis HE, McCorkell L, Vogel JM, Topol EJ. Long COVID: major findings, mechanisms and recommendations. Nature Reviews Microbiology. 2023 Mar;21(3):133-46. https://www.nature.com/articles/S41579-022-00846-2
- Batiha GE, Al-Kuraishy HM, Al-Gareeb AI, Welson NN. Pathophysiology of Post-COVID syndromes: a new perspective. Virology Journal. 2022 Oct 9;19(1):158. https://link.springer.com/article/10.1186/s12985-022-01891-2
- Mazza MG, Palladini M, Poletti S, Benedetti F. Post-COVID-19 depressive symptoms: epidemiology, pathophysiology, and pharmacological treatment. CNS drugs. 2022 Jul;36(7):681-702. https://link.springer.com/article/10.1007/s40263-022-00931-3 11.
- Renaud-Charest, Olivier, et al. "Onset and frequency of depression in post-COVID-19 syndrome: A systematic review." Journal of psychiatric research 144 (2021): 129-137.
- Saha, Sangita, et al. "Individualized homeopathic medicines in the treatment of post-COVID-19 fatigue in adults: A single-blind, randomized, placebo-controlled trial." Complementary Medicine Research (2023): 1-1.
- Tripathy, Dr Tridibesh, and Dr Manjushree Kar Shankar Das. "Long COVID 19 & Homoeopathy." Saudi J Med 7.1 (2022): 84-87.
- Yang, Fengwen, et al. "Post COVID-19 burden focus on the short-term condition." Acupuncture and Herbal Medicine 2.3 (2022): 139.
- Fawzy, Nader A., et al. "A systematic review of trials currently investigating therapeutic modalities for post-acute covid-19 syndrome and registered on World Health Organization International Clinical Trials Platform." Clinical Microbiology and Infection (2023).
- Karosanidze, Irina, et al. "Efficacy of adaptogens in patients with long COVID-19: a randomized, quadruple-blind, placebo-controlled trial." Pharmaceuticals 15.3 (2022): 345.
- Sheeba, S., et al. "A clinical case study of treating Post Covid Syndrome by Administrating Calcarea Carbonica 200 Potency with Assessment of IgG Level." (2023).
- Akter, Salima, et al. "Alternative medicine: A recent overview." Alternative Medicine-Update (2021).
- Lidiia, Soprun, et al. "The post-COVID syndrome." Autoimmunity, COVID-19, Post-COVID19 Syndrome and COVID-19 Vaccination. Academic Press, 2023. 747-758.
- Carson, Erin, and Alice N. Hemenway. "A scoping review of pharmacological management of postacute sequelae of severe acute respiratory syndrome coronavirus 2 infection in 2021." American Journal of Therapeutics 29.3 (2022): e305-e321.
- Adambaev, Z. I., et al. "Efficiency of comprehensive rehabilitation of chronic fatigue syndrome due to coronavirus infections COVID-19." BIO Web of Conferences. Vol. 65. EDP Sciences, 2023.
- Hendawy, Lina. "Adiantum capillus-veneris Linn (Maidenhair fern) extract-based drug as a symptomatic treatment for COVID-19.(clinical candidate)." (2020).
- Matsuoka, Norihiro, Takuo Mizutani, and Koji Kawakami. "Symptom Profile of Patients With Post-COVID-19 Conditions and Influencing Factors for Recovery." Journal of Clinical Medicine Research 15.2 (2023): 116.
- Trüeb, Ralph M., et al. "The Hair and Scalp in Systemic Infectious Disease." Hair in Infectious Disease: Recognition, Treatment, and Prevention. Cham: Springer International Publishing, 2023. 303-365.
- Lemcke, Tim Frederik. Retrospective analysis of post-COVID-19 symptoms in hospitalized patients, comparing the different SARS-COV- 2-variants regarding headache. Diss. University of Split. School of Medicine, 2023.
- Nauman, Eileen. Homeopathy for Epidemics. Light Technology Publishing, 2004.
- WAHAB, SHADMA. "LONG COVID MEDICAL COMPLICATIONS." The Novel Coronavirus (2023): 76.
- Majumder, Rajib, et al. "Revisiting the COVID-19 Pandemic: An Insight into Long-Term Post-COVID Complications and Repurposing of Drugs." COVID 3.4 (2023): 494-519.
- Wan, Minying, et al. "Post-acute COVID-19 syndrome and Long Haulers." American Journal of Translational Medicine 5.3 (2021): 125- 137.
References
Sreehitha, Daliparthy Sai, and Justina M. Steefan. "Efficacy of homoeopathy in treating post-COVID fatigue in adults using fatigue assessment scale. IJHS. 2023;7(1):37-42. https://www.homoeopathicjournal.com/articles/729/7-1-9-845.pdf
Kaur H, Bawaskar R, Khobragade A, Kalra D, Packiam V, Khan MY, Kaur T, Sharma M, Verma NK, Kaushik S, Khurana A. Randomised controlled trial to compare efficacy of standard care alone and in combination with homoeopathic treatment of moderate/severe COVID-19 cases. Plos one. 2023 Nov 15;18(11):e0292783. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0292783
Dixit AK, Giri N, Singh S. Exploring the scope of homoeopathy in combating the unfortunate consequences of post-COVID-19 survivors based on non-COVID conditions: a narrative review. Journal of Complementary and Integrative Medicine. 2023 Jun 15;20(2):302-15. https://www.degruyter.com/document/doi/10.1515/jcim-2021-0200/html
Chaudhary, Anupriya, and Anil Khurana. A review on the role of Homoeopathy in epidemics with some reflections on COVID‑19 (SARS‑CoV‑2). 2020. http://aohindia.in/jspui/handle/123456789/7482
Nayak D, Devarajan K, Pal PP, Ponnam HB, Jain N, Shastri V, Bawaskar R, Chinta R, Khurana A, COVID-19 Study Group. Efficacy of Arsenicum album 30C in the Prevention of COVID-19 in Individuals Residing in Containment Areas: A Prospective, Multicenter, Cluster-Randomized, Parallel-Arm, Community-Based, Open-Label Study. Complementary Medicine Research. 2023 Nov 1;30(5):375-85. https://karger.com/cmr/article/30/5/375/836949
Yadav M, Mangal G, Garg G. COVID-19-Understanding the emerging viral disease through the concepts of Ayurveda. Journal of Ayurveda. 2020 Oct 1;14(4):16-21. https://journals.lww.com/joay/fulltext/2020/14040/covid_19__understanding_the_emerging_viral_disease.5.aspx
Townsend L, Moloney D, Finucane C, McCarthy K, Bergin C, Bannan C, Kenny RA. Fatigue following COVID-19 infection is not associated with autonomic dysfunction. PloS one. 2021 Feb 25;16(2):e0247280. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0247280
Davis HE, McCorkell L, Vogel JM, Topol EJ. Long COVID: major findings, mechanisms and recommendations. Nature Reviews Microbiology. 2023 Mar;21(3):133-46. https://www.nature.com/articles/S41579-022-00846-2
Batiha GE, Al-Kuraishy HM, Al-Gareeb AI, Welson NN. Pathophysiology of Post-COVID syndromes: a new perspective. Virology Journal. 2022 Oct 9;19(1):158. https://link.springer.com/article/10.1186/s12985-022-01891-2
Mazza MG, Palladini M, Poletti S, Benedetti F. Post-COVID-19 depressive symptoms: epidemiology, pathophysiology, and pharmacological treatment. CNS drugs. 2022 Jul;36(7):681-702. https://link.springer.com/article/10.1007/s40263-022-00931-3 11.
Renaud-Charest, Olivier, et al. "Onset and frequency of depression in post-COVID-19 syndrome: A systematic review." Journal of psychiatric research 144 (2021): 129-137.
Saha, Sangita, et al. "Individualized homeopathic medicines in the treatment of post-COVID-19 fatigue in adults: A single-blind, randomized, placebo-controlled trial." Complementary Medicine Research (2023): 1-1.
Tripathy, Dr Tridibesh, and Dr Manjushree Kar Shankar Das. "Long COVID 19 & Homoeopathy." Saudi J Med 7.1 (2022): 84-87.
Yang, Fengwen, et al. "Post COVID-19 burden focus on the short-term condition." Acupuncture and Herbal Medicine 2.3 (2022): 139.
Fawzy, Nader A., et al. "A systematic review of trials currently investigating therapeutic modalities for post-acute covid-19 syndrome and registered on World Health Organization International Clinical Trials Platform." Clinical Microbiology and Infection (2023).
Karosanidze, Irina, et al. "Efficacy of adaptogens in patients with long COVID-19: a randomized, quadruple-blind, placebo-controlled trial." Pharmaceuticals 15.3 (2022): 345.
Sheeba, S., et al. "A clinical case study of treating Post Covid Syndrome by Administrating Calcarea Carbonica 200 Potency with Assessment of IgG Level." (2023).
Akter, Salima, et al. "Alternative medicine: A recent overview." Alternative Medicine-Update (2021).
Lidiia, Soprun, et al. "The post-COVID syndrome." Autoimmunity, COVID-19, Post-COVID19 Syndrome and COVID-19 Vaccination. Academic Press, 2023. 747-758.
Carson, Erin, and Alice N. Hemenway. "A scoping review of pharmacological management of postacute sequelae of severe acute respiratory syndrome coronavirus 2 infection in 2021." American Journal of Therapeutics 29.3 (2022): e305-e321.
Adambaev, Z. I., et al. "Efficiency of comprehensive rehabilitation of chronic fatigue syndrome due to coronavirus infections COVID-19." BIO Web of Conferences. Vol. 65. EDP Sciences, 2023.
Hendawy, Lina. "Adiantum capillus-veneris Linn (Maidenhair fern) extract-based drug as a symptomatic treatment for COVID-19.(clinical candidate)." (2020).
Matsuoka, Norihiro, Takuo Mizutani, and Koji Kawakami. "Symptom Profile of Patients With Post-COVID-19 Conditions and Influencing Factors for Recovery." Journal of Clinical Medicine Research 15.2 (2023): 116.
Trüeb, Ralph M., et al. "The Hair and Scalp in Systemic Infectious Disease." Hair in Infectious Disease: Recognition, Treatment, and Prevention. Cham: Springer International Publishing, 2023. 303-365.
Lemcke, Tim Frederik. Retrospective analysis of post-COVID-19 symptoms in hospitalized patients, comparing the different SARS-COV- 2-variants regarding headache. Diss. University of Split. School of Medicine, 2023.
Nauman, Eileen. Homeopathy for Epidemics. Light Technology Publishing, 2004.
WAHAB, SHADMA. "LONG COVID MEDICAL COMPLICATIONS." The Novel Coronavirus (2023): 76.
Majumder, Rajib, et al. "Revisiting the COVID-19 Pandemic: An Insight into Long-Term Post-COVID Complications and Repurposing of Drugs." COVID 3.4 (2023): 494-519.
Wan, Minying, et al. "Post-acute COVID-19 syndrome and Long Haulers." American Journal of Translational Medicine 5.3 (2021): 125- 137.