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A Case report on Toxic Epidermal Necrolysis
Corresponding Author(s) : Saginala Dharani
International Journal of Allied Medical Sciences and Clinical Research,
Vol. 12 No. 1 (2024): 2024 Volume -12 - Issue 1
Abstract
Toxic epidermal necrolysis (TEN) is a group of severe forms of several life-threatening conditions. As a co-infection of this group, Stevens-Johnson syndrome (SJS) is a rare though severe disease of the skin and mucous membranes. Intake of some drugs could cause reactions such as SJS and TEN. A form of severe connective tissue disorder, TEN is also known as Lyell's syndrome and is a common cause of significant skin and mucous membrane disintegration in the majority of cases, the administration of pharmaceutical drugs is thought to be the primary cause of SJS/TEN. In this article, we report a case of a 60-year-old Female patient who presented with complaints of multiple fluid filled blisters and raw surfaces on the body which was developed after administration of Aceclofenac, cefixime and gentamycin. Proper counselling to the patient regarding the use of medications is very important in such life-threatening condition’s where treatment guidelines remain hazy.
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- Pamnani S, Bakshi SS, Acharya S. Toxic epidermal necrolysis: A case report on a drug-induced phenomenon. Cureus. 2022 Oct 17;14(10):e30407. doi: 10.7759/cureus.30407, PMID 36407163.
- Qadir SNR, Raza N, Qadir F. Drug induced toxic epidermal necrolysis: two case reports. Cases J. 2009;2:7765. doi: 10.4076/1757-1626-2-7765, PMID 19918478.
- Statescu, Laura & Constantin, Magda & Morariu, Silviu-Horia & Solovastru. J Crit Care Med. 2017. Toxic Epidermal Necrolysis - A Case Report.;2. doi: 10.1515/jccm-2017-0002.
- Martina, Stojčić, Elvira, Ilić MK. Klancir, Tino & nesek adam, Visnja & Matolić. Acta Dermatovenerol Croat. 2017. Antibiotic-induced Toxic Epidermal Necrolysis - A Case Report;25:72-6.
- Kumar V, Gari M, Chakraborty K, Ranjan R, Chandra A, Kumari KNimesulide induced toxic epidermal necrolysis: a rare case report. Int J Basic Clin Pharmacol. 2017;6(12):2939. doi: 10.18203/2319-2003.ijbcp20175223.
- Ahmed, Patel AN, Ashfaq PA, Siyabi KH-Siyabi, KhalidA case report of hydralazine-induced skin reaction: probable toxic epidermal necrolysis (TEN). Am J Case Rep. 2014;15:135-8. doi: 10.12659/AJCR.890038, PMID 24719674.
References
Pamnani S, Bakshi SS, Acharya S. Toxic epidermal necrolysis: A case report on a drug-induced phenomenon. Cureus. 2022 Oct 17;14(10):e30407. doi: 10.7759/cureus.30407, PMID 36407163.
Qadir SNR, Raza N, Qadir F. Drug induced toxic epidermal necrolysis: two case reports. Cases J. 2009;2:7765. doi: 10.4076/1757-1626-2-7765, PMID 19918478.
Statescu, Laura & Constantin, Magda & Morariu, Silviu-Horia & Solovastru. J Crit Care Med. 2017. Toxic Epidermal Necrolysis - A Case Report.;2. doi: 10.1515/jccm-2017-0002.
Martina, Stojčić, Elvira, Ilić MK. Klancir, Tino & nesek adam, Visnja & Matolić. Acta Dermatovenerol Croat. 2017. Antibiotic-induced Toxic Epidermal Necrolysis - A Case Report;25:72-6.
Kumar V, Gari M, Chakraborty K, Ranjan R, Chandra A, Kumari KNimesulide induced toxic epidermal necrolysis: a rare case report. Int J Basic Clin Pharmacol. 2017;6(12):2939. doi: 10.18203/2319-2003.ijbcp20175223.
Ahmed, Patel AN, Ashfaq PA, Siyabi KH-Siyabi, KhalidA case report of hydralazine-induced skin reaction: probable toxic epidermal necrolysis (TEN). Am J Case Rep. 2014;15:135-8. doi: 10.12659/AJCR.890038, PMID 24719674.