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Pharmaceutical and Biomedical Applications of Gold Nanoparticles
Corresponding Author(s) : A. Sathyaraj
International Journal of Allied Medical Sciences and Clinical Research,
Vol. 11 No. 4 (2023): 2023 Volume -11 - Issue 4
Abstract
Gold nanoparticles (GNPs) have been extensively used in various applications in pharmaceuticals applications. Due to their unique characteristics such as tunable surface properties as well as surface plasmon resonance (SPR), GNPs have garnered attention in various applications exclusively in therapy and diagnostics. Gold nanoparticles (GNPs) are one of many NPs that have long been the focus of research. Due to their flexibility in synthesis and functionalization, GNPs have been profoundly used in treatments and diagnostic purpose. This article discusses and highlights therapeutic characteristics of GNPs that have been exploited in biomedical applications in recent years to improve biomedical research in various biomedical field such as nuclear medicine, molecular imaging and contrast agent, vaccine development, medical implant, diagnostics, biosensing, and lab-on-chip applications. At the forefront of modern therapeutic technology, GNPs based cancer treatment, antiviral agents and etc., have great potential which is also highlighted briefly in this article
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- Chen F, Si P, de la Zerda A, Jokerst JV, Myung D. Gold nanoparticles: promising biomaterials for osteogenic/adipogenic regulation in bone repair. J Mater Chem B. 2023.
- Zhang Yangheng, Wang P, Wang Y, Li J, Icon D, Icon RC et al. Gold nanoparticles promote the bone regeneration of periodontal ligament stem cell sheets through activation of autophagy. Int J Nanomedicine. 2023.
- Gupta Arti, Pandey S, Yadav JS. A review on recent trends in green synthesis of gold nanoparticles for tuberculosis. Adv Pharm Bull. 2021;11(1):10-27. doi: 10.34172/apb.2021.002, PMID 33747849.
- Sivanesan S, Rajeshkumar S. Gold nanoparticles in diagnosis and treatment of Alzheimer’s disease. Nanobiotechnology Neurodegener Dis. 2019.
- Khan Suliman, Anwarul Hasan F Attar, Majid Sharifi, Rabeea Siddique. Fatima Mraiche and Mojtaba Falahati. Gold nanoparticle-based platforms for diagnosis and treatment of myocardial infarction. ACS Publications. 2020.
- Koushki K, Keshavarz Shahbaz S, Keshavarz Mohsen, Bezsonov EE, Sathyapalan T, Sahebkar A. Gold nanoparticles: multifaceted roles in the management of autoimmune disorders. Biomolecules. 2021;11(9). doi: 10.3390/biom11091289, PMID 34572503.
- Dhandapani S, Wang Rongbo, cheol Hwang Kc, Kim H, Kim Y-J. Enhanced skin anti-inflammatory and moisturizing action of gold nanoparticles produced utilizing Diospyros kaki fruit extracts. Arab J Chem. 2023;16(4). doi: 10.1016/j.arabjc.2023.104551.
- Goorani S, Koohi MK, Morovvati H, Hassan J, Ahmeda A, Zangeneh MM. Application of natural compounds–based gold nanoparticles for the treatment of hemolytic anemia in an anemic mouse model: formulation of a novel drug from relationship between the nanotechnology and hematology sciences. Appl Organomet Chem. 2020;34(4). doi: 10.1002/aoc.5475.
- Patra S, Singh M, Wasnik K, Pareek D, Gupta PS, Mukherjee S et al. Polymeric nanoparticle based diagnosis and nanomedicine for treatment and development of vaccines for cerebral malaria: a review on recent advancement. ACS Publications; 2021.
- Zhang J, Yang T, Huang W, Yu Y, Sun T. Applications of gold nanoparticles in brain diseases across the blood-brain barrier. Curr Med Chem. 2022;29(39):6063-83. doi: 10.2174/0929867329666220527121943, PMID 35638273.
- Ma Y, Cai Fanghao, Li Y, Chen J, Han F, Lin W. A review of the application of nanoparticles in the diagnosis and treatment of chronic kidney disease. Bioact Mater. 2020;5(3):732-43. doi: 10.1016/j.bioactmat.2020.05.002, PMID 32596555.
- Chang Y, Cho B, Lee Euiyeon, Kim J, Yoo Junsang, Sung J-S et al. Electromagnetized gold nanoparticles improve neurogenesis and cognition in the aged brain. Biomaterials. 2021;278:121157. doi: 10.1016/j.biomaterials.2021.121157, PMID 34601195.
- Xu XY, Moon SK, Kim J-K, Kim WJ, Kim Y-J, Kim H. Structural properties and anti-dermatitis effects of flavonoids-loaded gold nanoparticles prepared by Eupatorium japonicum. ORIGINAL research article. Front Pharmacol. 2022;13:1055378. doi: 10.3389/fphar.2022.1055378, PMID 36386212.
- Bai X, Wang Y, Song Z, Feng Y, Chen Y, Zhang D et al. The basic properties of gold nanoparticles and their applications in tumor diagnosis and treatment. Int J Mol Sci. 2020;21(7). doi: 10.3390/ijms21072480, PMID 32260051.
- Mateu Ferrando RM, Lay L, Polito L. Gold nanoparticle-based platforms for vaccine development. Drug Discov Today Technol. 2020;38:57-67. doi: 10.1016/j.ddtec.2021.02.001.
- Sengupta A, Azharuddin M, Al-Otaibi N, Hinkula J.
- Sengupta A, Azharuddin M, Al-Otaibi N, Hinkula J. Efficacy and immune response elicited by gold nanoparticle- based nanovaccines against infectious diseases. Vaccines. 2022;10(4). doi: 10.3390/vaccines10040505, PMID 35455254.
- Alomari G, Hamdan S, Al-Trad B. Gold nanoparticles as a promising treatment for diabetes and its complications: current and future potentials. Braz J Pharm Sci. 2021;57. doi: 10.1590/s2175-97902020000419040.
- Raj S, Sasidharan S, Tripathi T, Saudagar P. Biofunctionalized chrysin-conjugated gold nanoparticles neutralize Leishmania parasites with high efficacy. Int J Biol Macromol. 2022;205:211-9. doi: 10.1016/j.ijbiomac.2022.02.047, PMID 35183598.
- Alenazi F, Saleem M, Khaja ASS, Zafar M, Alharbi MS, Al Hagbani TA et al. Metformin encapsulated gold nanoparticles (MTF-GNPs): A promising antiglycation agent. Cell Biochem Funct. 2022;40(7):729-41. doi: 10.1002/cbf.3738, PMID 36098489.
- Silveira PCL, Rodrigues MS, Gelain DP, de Oliveira J. Gold nanoparticles application to the treatment of brain dysfunctions related to metabolic diseases: evidence from experimental studies. Metab Brain Dis. 2023;38(1):123-35. doi: 10.1007/s11011-022-00929-2, PMID 35922735.
- Dhandapani S, Wang Rongbo, cheol Hwang Kc, Kim H, Kim Y-J. Exploring the potential anti-inflammatory effect of biosynthesized gold nanoparticles using Isodon excisus leaf tissue in human keratinocytes. Arab J Chem. 2023;16(10). doi: 10.1016/j.arabjc.2023.105113.
References
Chen F, Si P, de la Zerda A, Jokerst JV, Myung D. Gold nanoparticles: promising biomaterials for osteogenic/adipogenic regulation in bone repair. J Mater Chem B. 2023.
Zhang Yangheng, Wang P, Wang Y, Li J, Icon D, Icon RC et al. Gold nanoparticles promote the bone regeneration of periodontal ligament stem cell sheets through activation of autophagy. Int J Nanomedicine. 2023.
Gupta Arti, Pandey S, Yadav JS. A review on recent trends in green synthesis of gold nanoparticles for tuberculosis. Adv Pharm Bull. 2021;11(1):10-27. doi: 10.34172/apb.2021.002, PMID 33747849.
Sivanesan S, Rajeshkumar S. Gold nanoparticles in diagnosis and treatment of Alzheimer’s disease. Nanobiotechnology Neurodegener Dis. 2019.
Khan Suliman, Anwarul Hasan F Attar, Majid Sharifi, Rabeea Siddique. Fatima Mraiche and Mojtaba Falahati. Gold nanoparticle-based platforms for diagnosis and treatment of myocardial infarction. ACS Publications. 2020.
Koushki K, Keshavarz Shahbaz S, Keshavarz Mohsen, Bezsonov EE, Sathyapalan T, Sahebkar A. Gold nanoparticles: multifaceted roles in the management of autoimmune disorders. Biomolecules. 2021;11(9). doi: 10.3390/biom11091289, PMID 34572503.
Dhandapani S, Wang Rongbo, cheol Hwang Kc, Kim H, Kim Y-J. Enhanced skin anti-inflammatory and moisturizing action of gold nanoparticles produced utilizing Diospyros kaki fruit extracts. Arab J Chem. 2023;16(4). doi: 10.1016/j.arabjc.2023.104551.
Goorani S, Koohi MK, Morovvati H, Hassan J, Ahmeda A, Zangeneh MM. Application of natural compounds–based gold nanoparticles for the treatment of hemolytic anemia in an anemic mouse model: formulation of a novel drug from relationship between the nanotechnology and hematology sciences. Appl Organomet Chem. 2020;34(4). doi: 10.1002/aoc.5475.
Patra S, Singh M, Wasnik K, Pareek D, Gupta PS, Mukherjee S et al. Polymeric nanoparticle based diagnosis and nanomedicine for treatment and development of vaccines for cerebral malaria: a review on recent advancement. ACS Publications; 2021.
Zhang J, Yang T, Huang W, Yu Y, Sun T. Applications of gold nanoparticles in brain diseases across the blood-brain barrier. Curr Med Chem. 2022;29(39):6063-83. doi: 10.2174/0929867329666220527121943, PMID 35638273.
Ma Y, Cai Fanghao, Li Y, Chen J, Han F, Lin W. A review of the application of nanoparticles in the diagnosis and treatment of chronic kidney disease. Bioact Mater. 2020;5(3):732-43. doi: 10.1016/j.bioactmat.2020.05.002, PMID 32596555.
Chang Y, Cho B, Lee Euiyeon, Kim J, Yoo Junsang, Sung J-S et al. Electromagnetized gold nanoparticles improve neurogenesis and cognition in the aged brain. Biomaterials. 2021;278:121157. doi: 10.1016/j.biomaterials.2021.121157, PMID 34601195.
Xu XY, Moon SK, Kim J-K, Kim WJ, Kim Y-J, Kim H. Structural properties and anti-dermatitis effects of flavonoids-loaded gold nanoparticles prepared by Eupatorium japonicum. ORIGINAL research article. Front Pharmacol. 2022;13:1055378. doi: 10.3389/fphar.2022.1055378, PMID 36386212.
Bai X, Wang Y, Song Z, Feng Y, Chen Y, Zhang D et al. The basic properties of gold nanoparticles and their applications in tumor diagnosis and treatment. Int J Mol Sci. 2020;21(7). doi: 10.3390/ijms21072480, PMID 32260051.
Mateu Ferrando RM, Lay L, Polito L. Gold nanoparticle-based platforms for vaccine development. Drug Discov Today Technol. 2020;38:57-67. doi: 10.1016/j.ddtec.2021.02.001.
Sengupta A, Azharuddin M, Al-Otaibi N, Hinkula J.
Sengupta A, Azharuddin M, Al-Otaibi N, Hinkula J. Efficacy and immune response elicited by gold nanoparticle- based nanovaccines against infectious diseases. Vaccines. 2022;10(4). doi: 10.3390/vaccines10040505, PMID 35455254.
Alomari G, Hamdan S, Al-Trad B. Gold nanoparticles as a promising treatment for diabetes and its complications: current and future potentials. Braz J Pharm Sci. 2021;57. doi: 10.1590/s2175-97902020000419040.
Raj S, Sasidharan S, Tripathi T, Saudagar P. Biofunctionalized chrysin-conjugated gold nanoparticles neutralize Leishmania parasites with high efficacy. Int J Biol Macromol. 2022;205:211-9. doi: 10.1016/j.ijbiomac.2022.02.047, PMID 35183598.
Alenazi F, Saleem M, Khaja ASS, Zafar M, Alharbi MS, Al Hagbani TA et al. Metformin encapsulated gold nanoparticles (MTF-GNPs): A promising antiglycation agent. Cell Biochem Funct. 2022;40(7):729-41. doi: 10.1002/cbf.3738, PMID 36098489.
Silveira PCL, Rodrigues MS, Gelain DP, de Oliveira J. Gold nanoparticles application to the treatment of brain dysfunctions related to metabolic diseases: evidence from experimental studies. Metab Brain Dis. 2023;38(1):123-35. doi: 10.1007/s11011-022-00929-2, PMID 35922735.
Dhandapani S, Wang Rongbo, cheol Hwang Kc, Kim H, Kim Y-J. Exploring the potential anti-inflammatory effect of biosynthesized gold nanoparticles using Isodon excisus leaf tissue in human keratinocytes. Arab J Chem. 2023;16(10). doi: 10.1016/j.arabjc.2023.105113.