Design and characterisation of antihyperlipidemic drug rosuvastatin calcium nanoparticles
Corresponding Author(s) : Sugata Datta
dattasugata2@gmail.com
International Journal of Allied Medical Sciences and Clinical Research,
Vol. 11 No. 2 (2023): 2023 Volume -11 - Issue 2
Abstract
The objective of the present study was to formulate and evaluate polymeric nanoparticles of Rosuvastatin by Emulsification sonication method using Sodium alginate, Chitosanand Ethyl celluloseas a polymers. The nanoparticles were characterized for FTIR, particle size, poly-dispersity index, entrapment efficiency (EE), zeta potential, morphological study, DSC andinvitro study. Infrared studies showed that there was no drug excipients interaction. Negative values of zetapotential indicated the good stabilization of the prepared nanoparticles. The entrapment efficiency was found in between 51.82% – 75.14%. The in-vitro drug release was extended maximum up to 48hrs with Chitosan. The curve fitting data shows that the drug release followed first order kinetics.SEM shows that nanoparticles were found spherical in structure without aggregation and uniform distribution of the drug within the nanoparticles.
Keywords
Rosuvastatin, Emulsification sonication method, odium alginate, Chitosan,Ethyl cellulose and Nanoparticles.
1.
Sugata Datta, Mithun Bhowmick, Tulshi Chakraborty, Pratibha Bhowmick. Design and characterisation of antihyperlipidemic drug rosuvastatin calcium nanoparticles. Int. J. of Allied Med. Sci. and Clin. Res. [Internet]. 2023 May 8 [cited 2025 Jul. 13];11(2):166-75. Available from: https://ijamscr.com/ijamscr/article/view/1322
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References
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References
1. Hasan S. A review on nanoparticles: theirsynthesis and typesbiosynthesis: Mechanism 4; 2015. p. 9-11.
2. Assessment R.Nanoparticles Environ. 2007.
3. Cho EJ, Holback H, Liu KC, Abouelmagd SA, Park J, Yeo Y. Nanoparticle characterization: state of the art, challenges, and emerging technologies. Mol Pharm. 2013;10(6):2093-110. doi: 10.1021/mp300697h, PMID 23461379.
4. Machado S, Pacheco JG, Nouws HPA, Albergaria JT, Delerue-Matos C. Characterization of green zero-valent iron nanoparticles produced with tree leaf extracts.Sci Total Environ. 2015;533:76-81. doi: 10.1016/j.scitotenv.2015.06.091, PMID 26151651.
5. TiruwaR. A review on nanoparticles – preparation and evaluation parameters.Indian JPharmBiolRes.2015;4(2):27-31. doi: 10.30750/ijpbr.4.2.4.
6. Abhilash M.Potential applications of Nanoparticles.IntJ Pharm BiolSci.2010;1(1):1-12.
7. Nagavarma BVN, YadavHKS, Ayuz A, Vasudha LS, Shivakumar HG.Different techniques for preparation of polymeric nanoparticles – areview.Asian J Pharm ClinRes.2012;5(3):1-8.
8. Mullaicharam AR.Nanoparticles in drug delivery system.IntJ NutrPharmacolNeurolDis.2011;1(2):103-21. doi: 10.4103/2231-0738.84194.
9. Langer R. Biomaterials in drug delivery and tissue engineering; one laboratory’s experience. AccChem Res. 2000;33(2):94-101. doi: 10.1021/ar9800993, PMID 10673317.
10. Bhadra D, Bhadra S, Jain P, Jain NK. Pegnology; a review of pegylated systems; Pharmazin.Pharmazie.2002;57(1):5-29. PMID 11836932.
11. Tiwari DK, Behari J, Sen P. Application of nanoparticles in wastewaterTreatment 3; 2008. p. 417-33.
12. Salavati-niasari M, Davar F, Mir N. Synthesis and characterization of metallic copper nanoparticles via thermal decomposition Polyhedron 27; 2008. p. 3514-8.
13. Tai CY, Tai C, Chang M, Liu H. Synthesis of magnesiumhydroxide and oxidenanoparticlesusing a spinningdiskReactor 5536–41; 2007.
14. Bhaviripudi S, Mile E, Iii. SAS, Zare A T, Dresselhaus M S. Belcher A M and Kong J2007CVD Synthesis of Single-Walled Carbon Nanotubes from Gold Nanoparticle Catalysts 1516–7.
15. AlloucheJ.Synthesis of organic and bioorganicnanoparticles: anoverview of the preparationmethods.Springer-Verlag London;2013. p. 27-30.
16. Tamizhrasi S, Shukla A, Shivkumar T, Rathi V, Rathi JC.Formulation and evaluation of lamivudine loaded polymethacrylic acid nanoparticles, International Journal of PharmTech Research IJPRIF2009;1(3):411-5.
17. Mohanraj VJ, Chen Y.Research articlenanoparticles – areview.TropJ PharmRes.2006;5(1):561-73.
2. Assessment R.Nanoparticles Environ. 2007.
3. Cho EJ, Holback H, Liu KC, Abouelmagd SA, Park J, Yeo Y. Nanoparticle characterization: state of the art, challenges, and emerging technologies. Mol Pharm. 2013;10(6):2093-110. doi: 10.1021/mp300697h, PMID 23461379.
4. Machado S, Pacheco JG, Nouws HPA, Albergaria JT, Delerue-Matos C. Characterization of green zero-valent iron nanoparticles produced with tree leaf extracts.Sci Total Environ. 2015;533:76-81. doi: 10.1016/j.scitotenv.2015.06.091, PMID 26151651.
5. TiruwaR. A review on nanoparticles – preparation and evaluation parameters.Indian JPharmBiolRes.2015;4(2):27-31. doi: 10.30750/ijpbr.4.2.4.
6. Abhilash M.Potential applications of Nanoparticles.IntJ Pharm BiolSci.2010;1(1):1-12.
7. Nagavarma BVN, YadavHKS, Ayuz A, Vasudha LS, Shivakumar HG.Different techniques for preparation of polymeric nanoparticles – areview.Asian J Pharm ClinRes.2012;5(3):1-8.
8. Mullaicharam AR.Nanoparticles in drug delivery system.IntJ NutrPharmacolNeurolDis.2011;1(2):103-21. doi: 10.4103/2231-0738.84194.
9. Langer R. Biomaterials in drug delivery and tissue engineering; one laboratory’s experience. AccChem Res. 2000;33(2):94-101. doi: 10.1021/ar9800993, PMID 10673317.
10. Bhadra D, Bhadra S, Jain P, Jain NK. Pegnology; a review of pegylated systems; Pharmazin.Pharmazie.2002;57(1):5-29. PMID 11836932.
11. Tiwari DK, Behari J, Sen P. Application of nanoparticles in wastewaterTreatment 3; 2008. p. 417-33.
12. Salavati-niasari M, Davar F, Mir N. Synthesis and characterization of metallic copper nanoparticles via thermal decomposition Polyhedron 27; 2008. p. 3514-8.
13. Tai CY, Tai C, Chang M, Liu H. Synthesis of magnesiumhydroxide and oxidenanoparticlesusing a spinningdiskReactor 5536–41; 2007.
14. Bhaviripudi S, Mile E, Iii. SAS, Zare A T, Dresselhaus M S. Belcher A M and Kong J2007CVD Synthesis of Single-Walled Carbon Nanotubes from Gold Nanoparticle Catalysts 1516–7.
15. AlloucheJ.Synthesis of organic and bioorganicnanoparticles: anoverview of the preparationmethods.Springer-Verlag London;2013. p. 27-30.
16. Tamizhrasi S, Shukla A, Shivkumar T, Rathi V, Rathi JC.Formulation and evaluation of lamivudine loaded polymethacrylic acid nanoparticles, International Journal of PharmTech Research IJPRIF2009;1(3):411-5.
17. Mohanraj VJ, Chen Y.Research articlenanoparticles – areview.TropJ PharmRes.2006;5(1):561-73.