Platelets and its Importance in the Human Body
Corresponding Author(s) : Anju Tomar
anjur347@gmail.com
International Journal of Allied Medical Sciences and Clinical Research,
Vol. 11 No. 2 (2023): 2023 Volume -11 - Issue 2
Abstract
There are primarily three types of cells in human blood. White blood cells , platelets, and red blood cells. The smallest of them, biconvex and without a nucleus, cells are known as platelets. Despite their small size, platelets have important roles in vascular healing, hemostasis, and thrombosis, according to a study of numerous literature. Serotonin, a hormone involved in biological processes like learning and happiness as well as physiological processes like sleep and appetite, is also produced by platelets. Platelets aid the adaptive immune system's antimicrobial response. Thrombocytopenia, a low platelet count, and thrombosis, a high platelet count, constitute related medical disorder in the human body. Studies have also been done on the platelet storage procedure. With incubation and agitation, platelets can be kept for up to 5 days in the blood center. Due to their shorter lifespan, platelets' constant availability is a major problem. The super specialty health care center uses platelets additive solution as one of the products to extend the shelf life of the platelets for preserving the platelets in the blood center. In light of the extensive literature review, it is clear that platelets are a crucial type of human cell, actively participating in a variety of biological and physiological processes within the body. On the other hand, because of its limited lifespan, storing platelets is a difficult task for every time availability.
Keywords
Platelets, Hemostasis, Thrombosis, Serotonin, Immune response, Storage, Life span, PAS solution.
1.
Anju Tomar, Manpreet Kaur Verma, Sanjay Verma. Platelets and its Importance in the Human Body. Int. J. of Allied Med. Sci. and Clin. Res. [Internet]. 2023 Apr. 22 [cited 2026 Mar. 8];11(2):136-41. Available from: https://ijamscr.com/ijamscr/article/view/1317
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References
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1. Machlus KR, Italiano JE. The incredible journey: From mega karyocyte development to platelet formation. J Cell Biol, 2013.201(6):785-96.
2. Periayah MH, Halim AS, Saad AZM. Mechanism action of platelets and Crucial Blood Coagulation Pathway sin Hemostasis. International journal of hematology-Oncology and Stem Cell Res, 2017.11(4):319-27.
3. Lebas H, et al. Platelets Areatthe Nexus of Vascular Diseases. Frontiersin Cardiovascular Medicine:2019.6(132).
4. Gremmel T, Frelinger AL, 3rd, Michelson AD. Platelet Physiology. Semin Thromb Hemost. 2016;42(3):191-204.
5. Solves Alcaina P. Platelet transfusion: and update on challenges and outcomes. J Blood Med. 2020;11:19-26. doi: 10.2147/JBM.S234374, PMID 32158298.
6. Machlus KR, Italiano JE, Jr. The incredible journey: From megakaryocyte development to platelet formation. J Cell Biol, 2013.201(6):785-96.
7. Thon JN, Italiano JE. Platelet formation. Semin Hematol. 2010;47(3):220-6.
8. Rumbaut RE, TP. Platelet-Vessel Wall Interactions in Hemostasis and Thrombosis. 2010. SanRafael(CA): Morgan & ClaypoolLifeSciences.
9. Koupenova M, Clancy L, Corkrey HA, Freedman JE. Circulating platelets as mediators of immunity, inflammation, andThrombosis. Circ Res. 2018;122(2):337-51. doi: 10.1161/CIRCRESAHA.117.310795, PMID 29348254.
10. Scharf RE. Platelet Signalingin Primary Haemostasis and Arterial Thrombus Formation: Part 1. Hamostaseologie. 2018;38(4):203-10. doi: 10.1055/s-0038-1675144, PMID 30352470.
11. Shahidi M. Thrombosis and von Wille brand Factor. Adv Exp Med Biol;2017(906):285-306.
12. Bakshi A, Tadi P. Biochemistry, serotonin. Stat Pearls [Internet]. 2021.
13. Jenne CN, Urrutia R, Kubes P. Platelets:bridging hemostasis, inflammation,and immunity. Int J. Lab Hematol, 2013.35(3):254-61.
14. Christie DJ, Swinehart CD. Human platelet activating antibodies. Semin Thromb Hemost. 1992;18(2):186-92.
15. Tang YQ. Yeaman,and M.E.Selsted, Antimicrobial peptides from human platelets.InfectImmun,2002.70(12): p. 6524-33.
16. Varon D, Shai E. Plateletsandtheirmicroparticlesaskeyplayersinpathophysiologicalresponses. J Thromb Haemost. 2015;13:S40-6. doi: 10.1111/jth.12976.
17. Kurokawa T, Ohkohchi N. Plateletsinliver disease, cancer and regeneration. World J Gastroenterol. 2017;23(18):3228-39.
18. van der Meer PF, Kerkhoffs JL, Curvers J, Scharenberg J, de Korte D, Brand A, et al. In vitro comparison of platelet storage in plasma and in four platelet additive solutions, and the effect of pathogen reduction: a proposal for an invitrorating system. Vox Sang. 2010;98(4):517-24. doi: 10.1111/j.1423-0410.2009.01283.x, PMID 19930144.
19. van der Meer PF. PAS or plasma for storage of platelets? A concise review. Transfus Med. 2016;26(5):339-42. doi: 10.1111/tme.12325, PMID 27273164.
20. van der Meer PF, de Korte D. Platelet additive solutions: a review of the Latest Developments and their clinical implications. Transfus Med Hemother. 2018;45(2):98-102. doi: 10.1159/000487513, PMID 29765292.
References
1. Machlus KR, Italiano JE. The incredible journey: From mega karyocyte development to platelet formation. J Cell Biol, 2013.201(6):785-96.
2. Periayah MH, Halim AS, Saad AZM. Mechanism action of platelets and Crucial Blood Coagulation Pathway sin Hemostasis. International journal of hematology-Oncology and Stem Cell Res, 2017.11(4):319-27.
3. Lebas H, et al. Platelets Areatthe Nexus of Vascular Diseases. Frontiersin Cardiovascular Medicine:2019.6(132).
4. Gremmel T, Frelinger AL, 3rd, Michelson AD. Platelet Physiology. Semin Thromb Hemost. 2016;42(3):191-204.
5. Solves Alcaina P. Platelet transfusion: and update on challenges and outcomes. J Blood Med. 2020;11:19-26. doi: 10.2147/JBM.S234374, PMID 32158298.
6. Machlus KR, Italiano JE, Jr. The incredible journey: From megakaryocyte development to platelet formation. J Cell Biol, 2013.201(6):785-96.
7. Thon JN, Italiano JE. Platelet formation. Semin Hematol. 2010;47(3):220-6.
8. Rumbaut RE, TP. Platelet-Vessel Wall Interactions in Hemostasis and Thrombosis. 2010. SanRafael(CA): Morgan & ClaypoolLifeSciences.
9. Koupenova M, Clancy L, Corkrey HA, Freedman JE. Circulating platelets as mediators of immunity, inflammation, andThrombosis. Circ Res. 2018;122(2):337-51. doi: 10.1161/CIRCRESAHA.117.310795, PMID 29348254.
10. Scharf RE. Platelet Signalingin Primary Haemostasis and Arterial Thrombus Formation: Part 1. Hamostaseologie. 2018;38(4):203-10. doi: 10.1055/s-0038-1675144, PMID 30352470.
11. Shahidi M. Thrombosis and von Wille brand Factor. Adv Exp Med Biol;2017(906):285-306.
12. Bakshi A, Tadi P. Biochemistry, serotonin. Stat Pearls [Internet]. 2021.
13. Jenne CN, Urrutia R, Kubes P. Platelets:bridging hemostasis, inflammation,and immunity. Int J. Lab Hematol, 2013.35(3):254-61.
14. Christie DJ, Swinehart CD. Human platelet activating antibodies. Semin Thromb Hemost. 1992;18(2):186-92.
15. Tang YQ. Yeaman,and M.E.Selsted, Antimicrobial peptides from human platelets.InfectImmun,2002.70(12): p. 6524-33.
16. Varon D, Shai E. Plateletsandtheirmicroparticlesaskeyplayersinpathophysiologicalresponses. J Thromb Haemost. 2015;13:S40-6. doi: 10.1111/jth.12976.
17. Kurokawa T, Ohkohchi N. Plateletsinliver disease, cancer and regeneration. World J Gastroenterol. 2017;23(18):3228-39.
18. van der Meer PF, Kerkhoffs JL, Curvers J, Scharenberg J, de Korte D, Brand A, et al. In vitro comparison of platelet storage in plasma and in four platelet additive solutions, and the effect of pathogen reduction: a proposal for an invitrorating system. Vox Sang. 2010;98(4):517-24. doi: 10.1111/j.1423-0410.2009.01283.x, PMID 19930144.
19. van der Meer PF. PAS or plasma for storage of platelets? A concise review. Transfus Med. 2016;26(5):339-42. doi: 10.1111/tme.12325, PMID 27273164.
20. van der Meer PF, de Korte D. Platelet additive solutions: a review of the Latest Developments and their clinical implications. Transfus Med Hemother. 2018;45(2):98-102. doi: 10.1159/000487513, PMID 29765292.
2. Periayah MH, Halim AS, Saad AZM. Mechanism action of platelets and Crucial Blood Coagulation Pathway sin Hemostasis. International journal of hematology-Oncology and Stem Cell Res, 2017.11(4):319-27.
3. Lebas H, et al. Platelets Areatthe Nexus of Vascular Diseases. Frontiersin Cardiovascular Medicine:2019.6(132).
4. Gremmel T, Frelinger AL, 3rd, Michelson AD. Platelet Physiology. Semin Thromb Hemost. 2016;42(3):191-204.
5. Solves Alcaina P. Platelet transfusion: and update on challenges and outcomes. J Blood Med. 2020;11:19-26. doi: 10.2147/JBM.S234374, PMID 32158298.
6. Machlus KR, Italiano JE, Jr. The incredible journey: From megakaryocyte development to platelet formation. J Cell Biol, 2013.201(6):785-96.
7. Thon JN, Italiano JE. Platelet formation. Semin Hematol. 2010;47(3):220-6.
8. Rumbaut RE, TP. Platelet-Vessel Wall Interactions in Hemostasis and Thrombosis. 2010. SanRafael(CA): Morgan & ClaypoolLifeSciences.
9. Koupenova M, Clancy L, Corkrey HA, Freedman JE. Circulating platelets as mediators of immunity, inflammation, andThrombosis. Circ Res. 2018;122(2):337-51. doi: 10.1161/CIRCRESAHA.117.310795, PMID 29348254.
10. Scharf RE. Platelet Signalingin Primary Haemostasis and Arterial Thrombus Formation: Part 1. Hamostaseologie. 2018;38(4):203-10. doi: 10.1055/s-0038-1675144, PMID 30352470.
11. Shahidi M. Thrombosis and von Wille brand Factor. Adv Exp Med Biol;2017(906):285-306.
12. Bakshi A, Tadi P. Biochemistry, serotonin. Stat Pearls [Internet]. 2021.
13. Jenne CN, Urrutia R, Kubes P. Platelets:bridging hemostasis, inflammation,and immunity. Int J. Lab Hematol, 2013.35(3):254-61.
14. Christie DJ, Swinehart CD. Human platelet activating antibodies. Semin Thromb Hemost. 1992;18(2):186-92.
15. Tang YQ. Yeaman,and M.E.Selsted, Antimicrobial peptides from human platelets.InfectImmun,2002.70(12): p. 6524-33.
16. Varon D, Shai E. Plateletsandtheirmicroparticlesaskeyplayersinpathophysiologicalresponses. J Thromb Haemost. 2015;13:S40-6. doi: 10.1111/jth.12976.
17. Kurokawa T, Ohkohchi N. Plateletsinliver disease, cancer and regeneration. World J Gastroenterol. 2017;23(18):3228-39.
18. van der Meer PF, Kerkhoffs JL, Curvers J, Scharenberg J, de Korte D, Brand A, et al. In vitro comparison of platelet storage in plasma and in four platelet additive solutions, and the effect of pathogen reduction: a proposal for an invitrorating system. Vox Sang. 2010;98(4):517-24. doi: 10.1111/j.1423-0410.2009.01283.x, PMID 19930144.
19. van der Meer PF. PAS or plasma for storage of platelets? A concise review. Transfus Med. 2016;26(5):339-42. doi: 10.1111/tme.12325, PMID 27273164.
20. van der Meer PF, de Korte D. Platelet additive solutions: a review of the Latest Developments and their clinical implications. Transfus Med Hemother. 2018;45(2):98-102. doi: 10.1159/000487513, PMID 29765292.