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Submitted
Apr 21, 2023
Published
Apr 21, 2023
A stability indicating rp-hplc method developement for the simultaneous determination of ketorolac and olopatadine in bulk and in its pharmaceutical dosage forms
Corresponding Author(s) : Y.Evangelin
kirn1987@gmail.com
International Journal of Allied Medical Sciences and Clinical Research,
Vol. 11 No. 2 (2023): 2023 Volume -11 - Issue 2
Abstract
A simple, rapid and precise reverse phase liquid chromatographic (RP-HPLC) method was developed and validated for the estimation of Ketorolac and Olopatadine. In this method an Symmetry C18, 250×4.6mm, (innertsil ODS). 5µ or equivalent in an isocratic mode utilizing Phosphate Buffer (4.6 pH): Acetonitrile (50:50%v/v) at a flow rate of 1.0 ml/ min and effluent was monitored at 219 nm. Olopatadine hydrochloride& Ketorolac tromethamine was 2.724, 3.849 minutes. The linearity range was found to be 25 to 150µl. The validated method was very linear and precise.
Keywords
ketorolac, olopatadine
Y.Evangelin, J.Ijeya, K.Sruthi, M.Sagar Babu, N.Hemanth Reddy, & S.Divya Sai Bhaskar. (2023). A stability indicating rp-hplc method developement for the simultaneous determination of ketorolac and olopatadine in bulk and in its pharmaceutical dosage forms. International Journal of Allied Medical Sciences and Clinical Research, 11(2), 129-135. Retrieved from https://ijamscr.com/ijamscr/article/view/1316
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References
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