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Submitted
December 13, 2022
Published
December 13, 2022
Evaluation of anti ulcer activity of ecliptaalba extract in experimental animal model
Corresponding Author(s) : Ch. Srinivas
suralabs.publications@gmail.com
International Journal of Allied Medical Sciences and Clinical Research,
Vol. 10 No. 4 (2022): 2022 Volume -10 - Issue 4
Abstract
The cause of ulceration in patients is mainly due to hyper secretion of gastric juice and also due to hyper secretion of pepsin. In traditional system of medicine a number of herbal preparations have been used for the treatment of peptic ulcers. There are various medicinal plants has been used for the treatment of gastrointestinal disorders. In view of this, in present study we have to evaluate the anti-ulcer activity of Eclipta Alba. Study was carried out, by using three methods i.e., alcohol, paracetamol and stress induced ulcers in rats pretreated with the doses of 250 mg/kg AQEA and ALEA, 10mg/kg Omeoprazole and 50 mg/kg Ranitidine.
To evaluate the antiulcer activity of aqueous and alcoholic extracts of Eclipta Alba leaves (AQEA and ALEA) at 250 doses using different experimentally induced gastric ulcer models in rats. Gastric ulcers were induced in rats by 80% alcohol, paracetamol and forced immersion stress induced methods. In alcohol induced ulcer model, paracetamol induced ulcer model and stress induced model the ulcer index was determined. Where as in stress induced ulcers stress plays an important role in ulcerogenesis.In alcohol-induced ulcers, AQEA and ALEA were effective in reducing lesion index and increasing the gastric mucus content. It was also effective in decreasing ulcer index in paracetamol-induced ulcers. All the results obtained with Eclipta Alba were dose dependent. The results suggest that AQEA and ALEA possesses significant and dose dependent antiulcer activity. The antiulcer activity of AQEA and ALEA can be attributed to its cytoprotective and antisecretory action.
To evaluate the antiulcer activity of aqueous and alcoholic extracts of Eclipta Alba leaves (AQEA and ALEA) at 250 doses using different experimentally induced gastric ulcer models in rats. Gastric ulcers were induced in rats by 80% alcohol, paracetamol and forced immersion stress induced methods. In alcohol induced ulcer model, paracetamol induced ulcer model and stress induced model the ulcer index was determined. Where as in stress induced ulcers stress plays an important role in ulcerogenesis.In alcohol-induced ulcers, AQEA and ALEA were effective in reducing lesion index and increasing the gastric mucus content. It was also effective in decreasing ulcer index in paracetamol-induced ulcers. All the results obtained with Eclipta Alba were dose dependent. The results suggest that AQEA and ALEA possesses significant and dose dependent antiulcer activity. The antiulcer activity of AQEA and ALEA can be attributed to its cytoprotective and antisecretory action.
Keywords
Eclipta Alba, antisecretory, cytoprotective, gastric ulcer, alcohol induced ulcers, paracetamol-induced ulcers and stress induced ulcers.
Mohammad Nousheen, Ch. Srinivas, & Ramya Sri. S. (2022). Evaluation of anti ulcer activity of ecliptaalba extract in experimental animal model. International Journal of Allied Medical Sciences and Clinical Research, 10(4), 463–470. https://doi.org/10.61096/ijamscr.v10.iss4.2022.463-470
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References
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1. Burks TF. Principles of pharmacology. International Thomson publishing Inc; 1995. p. 1063.
2. Kumar V, Abbas KA. FaustoN.Robbins and Cotranpathologicbasis of disease. 7thed.New Delhi: Elsevier Inc; 2004. p. 817.
3. Peptic UlcerDiagram. Available from:http://www.wanderiner.blogspot.com.
4. Glueck DH, Karimpour-Fard A, Mandel J, Muller KE. Probabilities for separating sets of order Statistics. Statistics (Ber). 2010;44(2):145-53. doi: 10.1080/02331880902986984, PMID 21243084.
5. Danger of ulcer. Available from:http://www.murrasaca.com/Gastriculcer.htm.
6. Allison MC, Howatson AG, Torrance CJ, Lee FD, Russell RI. Gastrointestinal damage associated with theuse of nonsteriodal anti-inflammatory drugs. N Engl J Med.1992;327(11):749-54. doi: 10.1056/NEJM199209103271101, PMID 1501650.
7. Lenz HJ, Ferrari-Taylor J, Isenberg JI. Wine and five percent ethanol are potent stimulants of gastric acid secretion in humans. Gastroenterology.1983;85(5):1082-7. doi: 10.1016/S0016-5085(83)80075-4, PMID 6618102.
8. Cohen S, Booth GHJr. Gastric acid secretion and lower-esophageal – sphincter pressurein response to coffee and caffeine. N Engl J Med.1975;293(18):897-9. doi: 10.1056/NEJM197510302931803, PMID 1177987.
9. Feldman EJ, Isenberg JI, Grossman MI. Gastric acid and gastrin response todecaffeinated coffee and a peptone meal. JAMA.1981;246(3):248-50. doi: 10.1001/jama.1981.03320030040027, PMID 6894624.
10. Dubey P, Sundram KR, Nundy S. Effect of tea on gastric acid secretion. Dig Dis Sci. 1984;29(3):202-6. doi: 10.1007/BF01296252, PMID 6546540.
11. Korman MG, Hansky J, Eaves ER, Schmidt GT. Influence of cigarette smoking onhealing and relapse in duodenal ulcer disease. Gastroenterology.1983;85(4):871-4. doi: 10.1016/0016-5085(83)90438-9, PMID 6136450.
12. Katschinski BD, Logan RFA, Edmond M, Langman MJS. Duodenal ulcer and refined carbohydrate intake, a case-control study assessing dietary fiber and refined sugar intake. Gut.1990;31(9):993-6. doi: 10.1136/gut.31.9.993, PMID 2170250.
13. Suadicani P, Hein HO, Gyntelberg F. Genetic and life-style determinants of peptic ulcer, a study of 3387 men aged 54 to 74 years, the Copenhagen male study. Scand J Gastroenterol.1999;34(1):12-7. doi: 10.1080/00365529950172763, PMID 10048726.
14. Yudkin J. Eating and ulcers. BMJ.1980;280(6212); Feb16[letter]:483-4. doi: 10.1136/bmj.280.6212.483-c, PMID 7370549.
15. Sonnenberg A. Dietary salt and gastric ulcer. Gut.1986;27(10):1138-42. doi: 10.1136/gut.27.10.1138, PMID 3781325.
16. Pfeiffer CJ, Cho CH, Cheema A, Saltman D. Reserpine-induced gastric ulcers: protection by lysosomal stabilization due to zinc. Eur J Pharmacol.1980;61(4):347-53. doi: 10.1016/0014-2999(80)90073-4, PMID 7371712.
17. Shive W, Snider RN, DuBilier B, Rude JC, Clark GE, Ravel JO. Glutamine in treatment of peptic ulcer; preliminary report. Tex State J Med.1957;53(11):840-2. PMID 13486539.
18. Chaturvedi A, Kumar MM, Bhawani G, Chaturvedi H, Kumar M, GoelRK. Effect of ethanolic extract of EugeniaJambolana seeds on gastric ulceration and secretion in rats. Indian J PhysiolPharmacol.2007;51(2):131-40. PMID 18175656.
References
1. Burks TF. Principles of pharmacology. International Thomson publishing Inc; 1995. p. 1063.
2. Kumar V, Abbas KA. FaustoN.Robbins and Cotranpathologicbasis of disease. 7thed.New Delhi: Elsevier Inc; 2004. p. 817.
3. Peptic UlcerDiagram. Available from:http://www.wanderiner.blogspot.com.
4. Glueck DH, Karimpour-Fard A, Mandel J, Muller KE. Probabilities for separating sets of order Statistics. Statistics (Ber). 2010;44(2):145-53. doi: 10.1080/02331880902986984, PMID 21243084.
5. Danger of ulcer. Available from:http://www.murrasaca.com/Gastriculcer.htm.
6. Allison MC, Howatson AG, Torrance CJ, Lee FD, Russell RI. Gastrointestinal damage associated with theuse of nonsteriodal anti-inflammatory drugs. N Engl J Med.1992;327(11):749-54. doi: 10.1056/NEJM199209103271101, PMID 1501650.
7. Lenz HJ, Ferrari-Taylor J, Isenberg JI. Wine and five percent ethanol are potent stimulants of gastric acid secretion in humans. Gastroenterology.1983;85(5):1082-7. doi: 10.1016/S0016-5085(83)80075-4, PMID 6618102.
8. Cohen S, Booth GHJr. Gastric acid secretion and lower-esophageal – sphincter pressurein response to coffee and caffeine. N Engl J Med.1975;293(18):897-9. doi: 10.1056/NEJM197510302931803, PMID 1177987.
9. Feldman EJ, Isenberg JI, Grossman MI. Gastric acid and gastrin response todecaffeinated coffee and a peptone meal. JAMA.1981;246(3):248-50. doi: 10.1001/jama.1981.03320030040027, PMID 6894624.
10. Dubey P, Sundram KR, Nundy S. Effect of tea on gastric acid secretion. Dig Dis Sci. 1984;29(3):202-6. doi: 10.1007/BF01296252, PMID 6546540.
11. Korman MG, Hansky J, Eaves ER, Schmidt GT. Influence of cigarette smoking onhealing and relapse in duodenal ulcer disease. Gastroenterology.1983;85(4):871-4. doi: 10.1016/0016-5085(83)90438-9, PMID 6136450.
12. Katschinski BD, Logan RFA, Edmond M, Langman MJS. Duodenal ulcer and refined carbohydrate intake, a case-control study assessing dietary fiber and refined sugar intake. Gut.1990;31(9):993-6. doi: 10.1136/gut.31.9.993, PMID 2170250.
13. Suadicani P, Hein HO, Gyntelberg F. Genetic and life-style determinants of peptic ulcer, a study of 3387 men aged 54 to 74 years, the Copenhagen male study. Scand J Gastroenterol.1999;34(1):12-7. doi: 10.1080/00365529950172763, PMID 10048726.
14. Yudkin J. Eating and ulcers. BMJ.1980;280(6212); Feb16[letter]:483-4. doi: 10.1136/bmj.280.6212.483-c, PMID 7370549.
15. Sonnenberg A. Dietary salt and gastric ulcer. Gut.1986;27(10):1138-42. doi: 10.1136/gut.27.10.1138, PMID 3781325.
16. Pfeiffer CJ, Cho CH, Cheema A, Saltman D. Reserpine-induced gastric ulcers: protection by lysosomal stabilization due to zinc. Eur J Pharmacol.1980;61(4):347-53. doi: 10.1016/0014-2999(80)90073-4, PMID 7371712.
17. Shive W, Snider RN, DuBilier B, Rude JC, Clark GE, Ravel JO. Glutamine in treatment of peptic ulcer; preliminary report. Tex State J Med.1957;53(11):840-2. PMID 13486539.
18. Chaturvedi A, Kumar MM, Bhawani G, Chaturvedi H, Kumar M, GoelRK. Effect of ethanolic extract of EugeniaJambolana seeds on gastric ulceration and secretion in rats. Indian J PhysiolPharmacol.2007;51(2):131-40. PMID 18175656.
2. Kumar V, Abbas KA. FaustoN.Robbins and Cotranpathologicbasis of disease. 7thed.New Delhi: Elsevier Inc; 2004. p. 817.
3. Peptic UlcerDiagram. Available from:http://www.wanderiner.blogspot.com.
4. Glueck DH, Karimpour-Fard A, Mandel J, Muller KE. Probabilities for separating sets of order Statistics. Statistics (Ber). 2010;44(2):145-53. doi: 10.1080/02331880902986984, PMID 21243084.
5. Danger of ulcer. Available from:http://www.murrasaca.com/Gastriculcer.htm.
6. Allison MC, Howatson AG, Torrance CJ, Lee FD, Russell RI. Gastrointestinal damage associated with theuse of nonsteriodal anti-inflammatory drugs. N Engl J Med.1992;327(11):749-54. doi: 10.1056/NEJM199209103271101, PMID 1501650.
7. Lenz HJ, Ferrari-Taylor J, Isenberg JI. Wine and five percent ethanol are potent stimulants of gastric acid secretion in humans. Gastroenterology.1983;85(5):1082-7. doi: 10.1016/S0016-5085(83)80075-4, PMID 6618102.
8. Cohen S, Booth GHJr. Gastric acid secretion and lower-esophageal – sphincter pressurein response to coffee and caffeine. N Engl J Med.1975;293(18):897-9. doi: 10.1056/NEJM197510302931803, PMID 1177987.
9. Feldman EJ, Isenberg JI, Grossman MI. Gastric acid and gastrin response todecaffeinated coffee and a peptone meal. JAMA.1981;246(3):248-50. doi: 10.1001/jama.1981.03320030040027, PMID 6894624.
10. Dubey P, Sundram KR, Nundy S. Effect of tea on gastric acid secretion. Dig Dis Sci. 1984;29(3):202-6. doi: 10.1007/BF01296252, PMID 6546540.
11. Korman MG, Hansky J, Eaves ER, Schmidt GT. Influence of cigarette smoking onhealing and relapse in duodenal ulcer disease. Gastroenterology.1983;85(4):871-4. doi: 10.1016/0016-5085(83)90438-9, PMID 6136450.
12. Katschinski BD, Logan RFA, Edmond M, Langman MJS. Duodenal ulcer and refined carbohydrate intake, a case-control study assessing dietary fiber and refined sugar intake. Gut.1990;31(9):993-6. doi: 10.1136/gut.31.9.993, PMID 2170250.
13. Suadicani P, Hein HO, Gyntelberg F. Genetic and life-style determinants of peptic ulcer, a study of 3387 men aged 54 to 74 years, the Copenhagen male study. Scand J Gastroenterol.1999;34(1):12-7. doi: 10.1080/00365529950172763, PMID 10048726.
14. Yudkin J. Eating and ulcers. BMJ.1980;280(6212); Feb16[letter]:483-4. doi: 10.1136/bmj.280.6212.483-c, PMID 7370549.
15. Sonnenberg A. Dietary salt and gastric ulcer. Gut.1986;27(10):1138-42. doi: 10.1136/gut.27.10.1138, PMID 3781325.
16. Pfeiffer CJ, Cho CH, Cheema A, Saltman D. Reserpine-induced gastric ulcers: protection by lysosomal stabilization due to zinc. Eur J Pharmacol.1980;61(4):347-53. doi: 10.1016/0014-2999(80)90073-4, PMID 7371712.
17. Shive W, Snider RN, DuBilier B, Rude JC, Clark GE, Ravel JO. Glutamine in treatment of peptic ulcer; preliminary report. Tex State J Med.1957;53(11):840-2. PMID 13486539.
18. Chaturvedi A, Kumar MM, Bhawani G, Chaturvedi H, Kumar M, GoelRK. Effect of ethanolic extract of EugeniaJambolana seeds on gastric ulceration and secretion in rats. Indian J PhysiolPharmacol.2007;51(2):131-40. PMID 18175656.
