A role of Excoecaria agallocha L against streptozotocin induced diabetes and diabetic neuropathy complications in TBARS in Rats
Corresponding Author(s) : G. Kiran
kirn1987@gmail.com
International Journal of Allied Medical Sciences and Clinical Research,
Vol. 10 No. 3 (2022): 2022 Volume -10 - Issue 3
Abstract
The present study was designed to investigate the effect of different extracts of Excoecaria agallocha L. against diabetes mellitus and its related complications. Diabetes was induced by intraperitoneal administration of streptozotocin STZ (60 mg/kg) for the development of diabetic neuropathy. Treatment with both the extracts significantly attenuated the parameters of oxidative stress in sciatic nerve of diabetic neuropathic rats. Also, level of nitrite, TNF-?, TGF-? and IL1? was significantly increased in sciatic nerve of diabetic neuropathy animals, that were ameliorated by treatment with Excoecaria agallocha L. extracts. Histopathological changes in sciatic nerve of diabetic rats were also reversed by the treatment. These findings suggested that the Excoecaria agallocha L. may be used to manage the diabetes mellitus and its related complications such as diabetic neuropathy
Keywords
Excoecaria agallocha, streptozotocin STZ, etc
1.
G. Kiran, B.Geethika reddy, K.Sushanth sekhar, B.Viswanadha reddy. A role of Excoecaria agallocha L against streptozotocin induced diabetes and diabetic neuropathy complications in TBARS in Rats. Int. J. of Allied Med. Sci. and Clin. Res. [Internet]. 2022 Sep. 15 [cited 2025 Sep. 21];10(3):325-31. Available from: https://ijamscr.com/ijamscr/article/view/1237
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References
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1. Alkan EE, Celik I. The therapeutics effects and toxic risk of Heracleum persicum Desf. extract on streptozotocin-induced diabetic rats. Toxicol Rep. 2018;5:919-26. doi: 10.1016/j.toxrep.2018.08.004, PMID 30225197.
2. Al-Malki AL, Barbour EK, Abulnaja KO, Moselhy SS. Management of hyperglycaemia by ethyl acetate extract of Balanites aegyptiaca (Desert Date). Molecules. 2015;20(8):14425-34. doi: 10.3390/molecules200814425, PMID 26262605.
3. Althunibat OY, Al Hroob AM, Abukhalil MH, Germoush MO, Bin-Jumah M, Mahmoud AM. Fisetin ameliorates oxidative stress, inflammation and apoptosis in diabetic cardiomyopathy. Life Sci. 2019;221:83-92. doi: 10.1016/j.lfs.2019.02.017, PMID 30742869.
4. Anchi P, Khurana A, Swain D, Samanthula G, Godugu C. Dramatic improvement in pharmacokinetic and pharmacodynamic effects of sustain release curcumin microparticles demonstrated in experimental type 1 diabetes model. Eur J Pharm Sci. 2019;130:200-14. doi: 10.1016/j.ejps.2019.02.002, PMID 30731237.
5. Anil Kumar V, Ammani K, Jobina R, Parasuraman P, Siddhardha B. Larvicidal activity of green synthesized silver nanoparticles using Excoecaria agallocha L. (Euphorbiaceae) leaf extract against Aedes aegypti. IET Nanobiotechnology. 2016;10(6):382-8. doi: 10.1049/iet-nbt.2015.0101, PMID 27906138.
6. Anjaneyulu AS, Rao VL, Sreedhar K. Agallochins J-L, new isopimarane diterpenoids from Excoecaria agallocha L. Nat Prod Res. 2003;17(1):27-32. doi: 10.1080/1057563021000027975, PMID 12674139.
7. Bai W, Zhang C, Chen H. Transcriptomic analysis of Momordica charantia polysaccharide on streptozotocin-induced diabetic rats. Gene. 2018;675:208-16. doi: 10.1016/j.gene.2018.06.106, PMID 30180967.
8. Balakrishnan BB, Krishnasamy K, Choi KC. Moringa concanensis Nimmo ameliorates hyperglycemia in 3T3-L1 adipocytes by up regulating PPAR? gamma, C/EBP-alpha via Akt signaling pathway and STZ-induced diabetic rats. Biomed Pharmacother. 2018;103:719-28. doi: 10.1016/j.biopha.2018.04.047.
9. Banerjee K, Das S, Choudhury P, Ghosh S, Baral R, Choudhuri SK. A novel approach of synthesizing and evaluating the anticancer potential of silver oxide nanoparticles in vitro. Chemotherapy. 2017;62(5):279-89. doi: 10.1159/000453446, PMID 28490010.
10. Barbari GR, Dorkoosh F, Amini M, Bahari Javan N, Sharifzadeh M, Atyabi F et al. Synthesis and characterization of a novel peptide-grafted Cs and evaluation of its nanoparticles for the oral delivery of insulin, in vitro, and in vivo study. Int J Nanomedicine. 2018;13:5127-38. doi: 10.2147/IJN.S161240, PMID 30233176.
11. Chang B, Jin C, Zhang W, Kong L, Yang JH, Lian FM et al. Euonymus Alatus in the treatment of diabetic nephropathy in rats. Am J Chin Med. 2012;40(6):1177-87. doi: 10.1142/S0192415X12500875, PMID 23227790.
12. Chang X, Lu K, Wang L, Lv M, Fu W. Astraglaus polysaccharide protects diabetic cardiomyopathy by activating NRG1/ErbB pathway. BioSci Trends. 2018;12(2):149-56. doi: 10.5582/bst.2018.01027, PMID 29607874.
References
1. Alkan EE, Celik I. The therapeutics effects and toxic risk of Heracleum persicum Desf. extract on streptozotocin-induced diabetic rats. Toxicol Rep. 2018;5:919-26. doi: 10.1016/j.toxrep.2018.08.004, PMID 30225197.
2. Al-Malki AL, Barbour EK, Abulnaja KO, Moselhy SS. Management of hyperglycaemia by ethyl acetate extract of Balanites aegyptiaca (Desert Date). Molecules. 2015;20(8):14425-34. doi: 10.3390/molecules200814425, PMID 26262605.
3. Althunibat OY, Al Hroob AM, Abukhalil MH, Germoush MO, Bin-Jumah M, Mahmoud AM. Fisetin ameliorates oxidative stress, inflammation and apoptosis in diabetic cardiomyopathy. Life Sci. 2019;221:83-92. doi: 10.1016/j.lfs.2019.02.017, PMID 30742869.
4. Anchi P, Khurana A, Swain D, Samanthula G, Godugu C. Dramatic improvement in pharmacokinetic and pharmacodynamic effects of sustain release curcumin microparticles demonstrated in experimental type 1 diabetes model. Eur J Pharm Sci. 2019;130:200-14. doi: 10.1016/j.ejps.2019.02.002, PMID 30731237.
5. Anil Kumar V, Ammani K, Jobina R, Parasuraman P, Siddhardha B. Larvicidal activity of green synthesized silver nanoparticles using Excoecaria agallocha L. (Euphorbiaceae) leaf extract against Aedes aegypti. IET Nanobiotechnology. 2016;10(6):382-8. doi: 10.1049/iet-nbt.2015.0101, PMID 27906138.
6. Anjaneyulu AS, Rao VL, Sreedhar K. Agallochins J-L, new isopimarane diterpenoids from Excoecaria agallocha L. Nat Prod Res. 2003;17(1):27-32. doi: 10.1080/1057563021000027975, PMID 12674139.
7. Bai W, Zhang C, Chen H. Transcriptomic analysis of Momordica charantia polysaccharide on streptozotocin-induced diabetic rats. Gene. 2018;675:208-16. doi: 10.1016/j.gene.2018.06.106, PMID 30180967.
8. Balakrishnan BB, Krishnasamy K, Choi KC. Moringa concanensis Nimmo ameliorates hyperglycemia in 3T3-L1 adipocytes by up regulating PPAR? gamma, C/EBP-alpha via Akt signaling pathway and STZ-induced diabetic rats. Biomed Pharmacother. 2018;103:719-28. doi: 10.1016/j.biopha.2018.04.047.
9. Banerjee K, Das S, Choudhury P, Ghosh S, Baral R, Choudhuri SK. A novel approach of synthesizing and evaluating the anticancer potential of silver oxide nanoparticles in vitro. Chemotherapy. 2017;62(5):279-89. doi: 10.1159/000453446, PMID 28490010.
10. Barbari GR, Dorkoosh F, Amini M, Bahari Javan N, Sharifzadeh M, Atyabi F et al. Synthesis and characterization of a novel peptide-grafted Cs and evaluation of its nanoparticles for the oral delivery of insulin, in vitro, and in vivo study. Int J Nanomedicine. 2018;13:5127-38. doi: 10.2147/IJN.S161240, PMID 30233176.
11. Chang B, Jin C, Zhang W, Kong L, Yang JH, Lian FM et al. Euonymus Alatus in the treatment of diabetic nephropathy in rats. Am J Chin Med. 2012;40(6):1177-87. doi: 10.1142/S0192415X12500875, PMID 23227790.
12. Chang X, Lu K, Wang L, Lv M, Fu W. Astraglaus polysaccharide protects diabetic cardiomyopathy by activating NRG1/ErbB pathway. BioSci Trends. 2018;12(2):149-56. doi: 10.5582/bst.2018.01027, PMID 29607874.
2. Al-Malki AL, Barbour EK, Abulnaja KO, Moselhy SS. Management of hyperglycaemia by ethyl acetate extract of Balanites aegyptiaca (Desert Date). Molecules. 2015;20(8):14425-34. doi: 10.3390/molecules200814425, PMID 26262605.
3. Althunibat OY, Al Hroob AM, Abukhalil MH, Germoush MO, Bin-Jumah M, Mahmoud AM. Fisetin ameliorates oxidative stress, inflammation and apoptosis in diabetic cardiomyopathy. Life Sci. 2019;221:83-92. doi: 10.1016/j.lfs.2019.02.017, PMID 30742869.
4. Anchi P, Khurana A, Swain D, Samanthula G, Godugu C. Dramatic improvement in pharmacokinetic and pharmacodynamic effects of sustain release curcumin microparticles demonstrated in experimental type 1 diabetes model. Eur J Pharm Sci. 2019;130:200-14. doi: 10.1016/j.ejps.2019.02.002, PMID 30731237.
5. Anil Kumar V, Ammani K, Jobina R, Parasuraman P, Siddhardha B. Larvicidal activity of green synthesized silver nanoparticles using Excoecaria agallocha L. (Euphorbiaceae) leaf extract against Aedes aegypti. IET Nanobiotechnology. 2016;10(6):382-8. doi: 10.1049/iet-nbt.2015.0101, PMID 27906138.
6. Anjaneyulu AS, Rao VL, Sreedhar K. Agallochins J-L, new isopimarane diterpenoids from Excoecaria agallocha L. Nat Prod Res. 2003;17(1):27-32. doi: 10.1080/1057563021000027975, PMID 12674139.
7. Bai W, Zhang C, Chen H. Transcriptomic analysis of Momordica charantia polysaccharide on streptozotocin-induced diabetic rats. Gene. 2018;675:208-16. doi: 10.1016/j.gene.2018.06.106, PMID 30180967.
8. Balakrishnan BB, Krishnasamy K, Choi KC. Moringa concanensis Nimmo ameliorates hyperglycemia in 3T3-L1 adipocytes by up regulating PPAR? gamma, C/EBP-alpha via Akt signaling pathway and STZ-induced diabetic rats. Biomed Pharmacother. 2018;103:719-28. doi: 10.1016/j.biopha.2018.04.047.
9. Banerjee K, Das S, Choudhury P, Ghosh S, Baral R, Choudhuri SK. A novel approach of synthesizing and evaluating the anticancer potential of silver oxide nanoparticles in vitro. Chemotherapy. 2017;62(5):279-89. doi: 10.1159/000453446, PMID 28490010.
10. Barbari GR, Dorkoosh F, Amini M, Bahari Javan N, Sharifzadeh M, Atyabi F et al. Synthesis and characterization of a novel peptide-grafted Cs and evaluation of its nanoparticles for the oral delivery of insulin, in vitro, and in vivo study. Int J Nanomedicine. 2018;13:5127-38. doi: 10.2147/IJN.S161240, PMID 30233176.
11. Chang B, Jin C, Zhang W, Kong L, Yang JH, Lian FM et al. Euonymus Alatus in the treatment of diabetic nephropathy in rats. Am J Chin Med. 2012;40(6):1177-87. doi: 10.1142/S0192415X12500875, PMID 23227790.
12. Chang X, Lu K, Wang L, Lv M, Fu W. Astraglaus polysaccharide protects diabetic cardiomyopathy by activating NRG1/ErbB pathway. BioSci Trends. 2018;12(2):149-56. doi: 10.5582/bst.2018.01027, PMID 29607874.