Antidiabetic Effect of Lonicera Ligustrina wall in Alloxan Induced Diabetes in Wistar Rats
Corresponding Author(s) : Heena Parveen
heenasidra@gmail.com
International Journal of Allied Medical Sciences and Clinical Research,
Vol. 10 No. 3 (2022): 2022 Volume -10 - Issue 3
Abstract
Diabetes, is a group of metabolic disorders characterized by a high blood sugar level (hyperglycaemia) over a prolonged period. The plant extract of Lonicera Ligustrina wall. was taken to treat Alloxan induced Diabetes in Wistar rats. Lonicera ligustrina wall. is a species of honeysuckle of family Caprifoliaceae. Animals were group into five. The control group animals were given normal saline for 14days. Group II animals were given Alloxan 120mg/kg body weight intraperitoneally until 14th day of the experiment. Group III animals were given Alloxan 120mg/kg i.p and Standard drug metformin hydrochloride 500mg/kg body weight i.p were given until 14 days. Group IV animals were given Alloxan 120mg/kg i.p and test dose of extract lonicera ligustrina wall 150mg/kg body weight i.p given up to 14th day. Group V animals were given Alloxan 120mg/kg i.p and test 2 dose of extract of Lonicera ligustrina wall 300mg/kg weight i.p given until 14days of the experiment.
Keywords
Hyperglycaemia, Lonicera ligustrina wall, Alloxan, Metformin Hydrochloride, Serum parameters.
1.
Heena Parveen, Somoju Rachana, M. Sudhakar, Aneesa Fathima. Antidiabetic Effect of Lonicera Ligustrina wall in Alloxan Induced Diabetes in Wistar Rats. Int. J. of Allied Med. Sci. and Clin. Res. [Internet]. 2022 Aug. 26 [cited 2025 Oct. 11];10(3):302-9. Available from: https://ijamscr.com/ijamscr/article/view/1225
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References
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1. Parveen Heena. A study on phytochemical & anti-nociceptive activity of Lonicera ligustrina leaf extract. Int J Allied Med Sci Clin Res. 2019 Volume 7- Issue -3;7(3).
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6. Pagliara AS, Stillings SN, Zawalich WS, Williams AD, Matchinsky FM. Glucose and 3-0-methylglucose protection against alloxan poisoning of pancreatic alpha and beta cells. Diabetes. 1977;26(10):973-9. doi: 10.2337/diab.26.10.973, PMID 332568.
7. Polyakova EB, Sabirzyanov DR, Prozorova NA, Foteeva AB. Physicochemical properties and methods for the determination of metformin hydrochloride. Vol. 03 februvary 2022.
8. Shi P, Liu X, Li T, Sun F-F, Liu YP, Liu SQ et al. Pharmacokinetics and bioequivalence of sitagliptin phosphate/metformin hydrochloride tablets in healthy Chinese subjects: A randomized, open-label, crossover study. Drugs R D. 2022;22(1), November 30 20211. doi: 10.1007/s40268-021-00371-2, PMID 34850368.
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12. Rang HP, Dale MM, Ritter JM, Moore PK. Pharmacology. 2nd ed. UK: Churchill Livingstone; 1993. p. 706-11.
References
1. Parveen Heena. A study on phytochemical & anti-nociceptive activity of Lonicera ligustrina leaf extract. Int J Allied Med Sci Clin Res. 2019 Volume 7- Issue -3;7(3).
2. Zygler A, Namiesnik J. Theory of extraction techniques in comprehensive sampling and sample preparation; 2012.
3. Laugesen E, Østergaard JA, Leslie RD, Danish Diabetes Academy Workshop and Workshop Speakers. Latent autoimmune diabetes of the adult: current knowledge and uncertainty. Diabet Med. July 2015;32(7):843-52. doi: 10.1111/dme.12700, PMID 25601320.
4. American Diabetes Association. Classification and diagnosis of diabetes"(January; 2017.
5. Mrozikiewicz A, Kie?czewska-Mrozikiewicz D, ?owicki Z, Chmara E. Blood levels of alloxan in children with insulin-dependent diabetes mellitus volume 31; 1994.
6. Pagliara AS, Stillings SN, Zawalich WS, Williams AD, Matchinsky FM. Glucose and 3-0-methylglucose protection against alloxan poisoning of pancreatic alpha and beta cells. Diabetes. 1977;26(10):973-9. doi: 10.2337/diab.26.10.973, PMID 332568.
7. Polyakova EB, Sabirzyanov DR, Prozorova NA, Foteeva AB. Physicochemical properties and methods for the determination of metformin hydrochloride. Vol. 03 februvary 2022.
8. Shi P, Liu X, Li T, Sun F-F, Liu YP, Liu SQ et al. Pharmacokinetics and bioequivalence of sitagliptin phosphate/metformin hydrochloride tablets in healthy Chinese subjects: A randomized, open-label, crossover study. Drugs R D. 2022;22(1), November 30 20211. doi: 10.1007/s40268-021-00371-2, PMID 34850368.
9. Kokate CK, Purohit AP. Pharmacognosy bool et al. January 1 2017.
10. Tropical Biomedicine. Oral acute toxicity study, OECD guidelines 425, 2008, 3. Vol. 4(10); 2014. p. 792-7.
11. NripendraNathBiswas SS, Ali MK. Antioxidant,antimicrobial, cytotoxic and analgesic activities of ethanolic extract of Menthaarvensis L. Asian pacific Journal of Pharmacology.
12. Rang HP, Dale MM, Ritter JM, Moore PK. Pharmacology. 2nd ed. UK: Churchill Livingstone; 1993. p. 706-11.
2. Zygler A, Namiesnik J. Theory of extraction techniques in comprehensive sampling and sample preparation; 2012.
3. Laugesen E, Østergaard JA, Leslie RD, Danish Diabetes Academy Workshop and Workshop Speakers. Latent autoimmune diabetes of the adult: current knowledge and uncertainty. Diabet Med. July 2015;32(7):843-52. doi: 10.1111/dme.12700, PMID 25601320.
4. American Diabetes Association. Classification and diagnosis of diabetes"(January; 2017.
5. Mrozikiewicz A, Kie?czewska-Mrozikiewicz D, ?owicki Z, Chmara E. Blood levels of alloxan in children with insulin-dependent diabetes mellitus volume 31; 1994.
6. Pagliara AS, Stillings SN, Zawalich WS, Williams AD, Matchinsky FM. Glucose and 3-0-methylglucose protection against alloxan poisoning of pancreatic alpha and beta cells. Diabetes. 1977;26(10):973-9. doi: 10.2337/diab.26.10.973, PMID 332568.
7. Polyakova EB, Sabirzyanov DR, Prozorova NA, Foteeva AB. Physicochemical properties and methods for the determination of metformin hydrochloride. Vol. 03 februvary 2022.
8. Shi P, Liu X, Li T, Sun F-F, Liu YP, Liu SQ et al. Pharmacokinetics and bioequivalence of sitagliptin phosphate/metformin hydrochloride tablets in healthy Chinese subjects: A randomized, open-label, crossover study. Drugs R D. 2022;22(1), November 30 20211. doi: 10.1007/s40268-021-00371-2, PMID 34850368.
9. Kokate CK, Purohit AP. Pharmacognosy bool et al. January 1 2017.
10. Tropical Biomedicine. Oral acute toxicity study, OECD guidelines 425, 2008, 3. Vol. 4(10); 2014. p. 792-7.
11. NripendraNathBiswas SS, Ali MK. Antioxidant,antimicrobial, cytotoxic and analgesic activities of ethanolic extract of Menthaarvensis L. Asian pacific Journal of Pharmacology.
12. Rang HP, Dale MM, Ritter JM, Moore PK. Pharmacology. 2nd ed. UK: Churchill Livingstone; 1993. p. 706-11.