Date Log
Submitted
April 20, 2022
Published
April 20, 2022
The Effect of Tahongai Leaf Extract (Kleinhovia Hospita Linn) on the Growth of Candida Albicans In Female Mice Vaginal Candidiasis
Corresponding Author(s) : Nur Syahria
nursyahria04@gmail.com
International Journal of Allied Medical Sciences and Clinical Research,
Vol. 10 No. 2 (2022): 2022 Volume - 10 Issue - 2
Abstract
Background
Vaginal discharge is one of the problems that occur in women and about 80% occurs at the age of 15-45 years. This can trigger the development of fungi that cause vaginal discharge and the risk of vaginal candidiasis, namely candida albicans yeast infection. Tahongai leaf medicinal plants contain phenolic compounds (flavonoids, tannins, terpenoids, alkaloids) which show the ability to treat vaginal discharge caused by candida albicans by inhibiting ergosterol in cell membranes and affecting the function of enzymes so that they are antifungal.
Purpose
Analyze the effect of Tahongai (Kleinhovia hospital linn) leaf extract at a dose of 500mg/kg BW and 750mg/kg BW for 14 days on the growth of candida albicans in female mice vaginal candidiasis.
Method
True experimental study of female mice (Mus musculus) which consisted of 4 groups, namely the experimental group at a dose of 500mg/kg BW, the experimental group 750mg/kg BW, the positive control group (Ketoconazole) which was given 1 x 1 for 14 days, and the control negative group.
Results
Tahongai leaf extract (Kleinhovia hospita linn) dose of 750mg/kgBB once daily for 14 days affected suppressing the growth of candida albicans in female mice vaginal candidiasis with a decrease in the average number of colonies of 31 cfu/ml with a p-value of 0.010 <0.05, while the Tahongai leaf extract dose of 500mg/kg BW showed a decrease in the number of colonies but not significant (p-value 0.430).
Conclusion
Tahongai leaf extract (Kleinhovia hospita linn) at a dose of 750mg/kgBW for 14 days affected suppressing the growth of candida albicans in female mice vaginal candidiasis.
Vaginal discharge is one of the problems that occur in women and about 80% occurs at the age of 15-45 years. This can trigger the development of fungi that cause vaginal discharge and the risk of vaginal candidiasis, namely candida albicans yeast infection. Tahongai leaf medicinal plants contain phenolic compounds (flavonoids, tannins, terpenoids, alkaloids) which show the ability to treat vaginal discharge caused by candida albicans by inhibiting ergosterol in cell membranes and affecting the function of enzymes so that they are antifungal.
Purpose
Analyze the effect of Tahongai (Kleinhovia hospital linn) leaf extract at a dose of 500mg/kg BW and 750mg/kg BW for 14 days on the growth of candida albicans in female mice vaginal candidiasis.
Method
True experimental study of female mice (Mus musculus) which consisted of 4 groups, namely the experimental group at a dose of 500mg/kg BW, the experimental group 750mg/kg BW, the positive control group (Ketoconazole) which was given 1 x 1 for 14 days, and the control negative group.
Results
Tahongai leaf extract (Kleinhovia hospita linn) dose of 750mg/kgBB once daily for 14 days affected suppressing the growth of candida albicans in female mice vaginal candidiasis with a decrease in the average number of colonies of 31 cfu/ml with a p-value of 0.010 <0.05, while the Tahongai leaf extract dose of 500mg/kg BW showed a decrease in the number of colonies but not significant (p-value 0.430).
Conclusion
Tahongai leaf extract (Kleinhovia hospita linn) at a dose of 750mg/kgBW for 14 days affected suppressing the growth of candida albicans in female mice vaginal candidiasis.
Keywords
Tahongai leaf extract
vaginal discharge
vaginal candidiasis
Nur Syahria, Suharyo Hadisaputro, & Yuni Kusmiyati. (2022). The Effect of Tahongai Leaf Extract (Kleinhovia Hospita Linn) on the Growth of Candida Albicans In Female Mice Vaginal Candidiasis. International Journal of Allied Medical Sciences and Clinical Research, 10(2), 148–151. https://doi.org/10.61096/ijamscr.v10.iss2.2022.148-151
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References
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1. Marhaeni GA, Wanita KPada, Husada JS. The J Health. 2016;13:(30-8).
2. Dhirah U, Anwar C. Promosi kesehatan tentang Flour Albus serta Penanganannya di sma negeri 8 Banda Aceh. J UuiAcId. 2020;2(1):38-40.
3. World Health Organization. Sex Transm Infect. 2016:2016-21.
4. Denning DW, Kneale M, Sobel JD, Rautemaa-richardson R. Review Global burden of recurrent vulvovaginal candidiasis: a systematic review. Lancet Infect Dis. 2018;3099(18):1-9. doi: 10.1016/S1473-3099(18)30103-8.
5. Ramasamy SL SC. Sexually Transmitted Disease and Leukorrhea in a Rural South Asian Himalayan Community?: A Study of Perceptions and Barriers to Treatment. Women’s health and wellness. 2019;5(2):1-7.
6. Azizah N, Widiawati I. Karakteristik remaja Putri dengan kejadian Keputihan di Smk Muhammadiyah kudus. Januari. 2015;6(1):57-78.
7. Handayani AM, Rochmah FZ, Firdaus RA, Cair Sabun. Granat putih ”(Punica granatum) sebagai obat Keputihan; 2017. p. 171-6.
8. Collins LM, Moore R, Sobel JD. Prognosis and long-term outcome of women with idiopathic recurrent vulvovaginal candidiasis caused by Candida albicans. J Low Genit Tract Dis. 2020;24(1):48-52. doi: 10.1097/LGT.0000000000000496, PMID 31860575.
9. Purwati S, Dewi SS, Prastyanto ME. Keanekaragaman Bakteri dan Jamur Pada Sekret Vagina Pasien Keputihan di RSUP dr. Kariadi Semarang. 2017;12:67.
10. Parwati NW, Djamil M. Vaginal discharge caused candida albicans: laboratory study. Int J Allied M Edical Sci Clin Res (IJAMSCR). 2019;7(1):91-5.
11. Zubair dkk. Studi Etnobotani Tumbuhan Obat Pada Masyarakat Kaili Rai Di Desa Wombo Kecamatan Tanantovea Kabupaten Donggala Sulawesi Tengah. Biocelebes. 2019;13(2):182-94.
12. Tahongai PS. (Kleinhovia hospita L.): review sebuah tumbuhan obat Dari Kalimantan timur. J Tumbuhan Obat Indones. 2016;9(1).
13. Zhou C, Zou L, Gan L, Cao Y, Kleinhospitines AÀD. New cycloartane triterpenoid alkaloids from Kleinhovia hospita. 2013;5:1813-6.
14. Komang A, Hambat D, DAYA HAMBAT CP. Pertumbuhan Candida albicans DAN DAYA BUNUH Candida albicans EKSTRAK DAUN KEMANGI (Ocimum sanctum l.). 2017;78-83.
References
1. Marhaeni GA, Wanita KPada, Husada JS. The J Health. 2016;13:(30-8).
2. Dhirah U, Anwar C. Promosi kesehatan tentang Flour Albus serta Penanganannya di sma negeri 8 Banda Aceh. J UuiAcId. 2020;2(1):38-40.
3. World Health Organization. Sex Transm Infect. 2016:2016-21.
4. Denning DW, Kneale M, Sobel JD, Rautemaa-richardson R. Review Global burden of recurrent vulvovaginal candidiasis: a systematic review. Lancet Infect Dis. 2018;3099(18):1-9. doi: 10.1016/S1473-3099(18)30103-8.
5. Ramasamy SL SC. Sexually Transmitted Disease and Leukorrhea in a Rural South Asian Himalayan Community?: A Study of Perceptions and Barriers to Treatment. Women’s health and wellness. 2019;5(2):1-7.
6. Azizah N, Widiawati I. Karakteristik remaja Putri dengan kejadian Keputihan di Smk Muhammadiyah kudus. Januari. 2015;6(1):57-78.
7. Handayani AM, Rochmah FZ, Firdaus RA, Cair Sabun. Granat putih ”(Punica granatum) sebagai obat Keputihan; 2017. p. 171-6.
8. Collins LM, Moore R, Sobel JD. Prognosis and long-term outcome of women with idiopathic recurrent vulvovaginal candidiasis caused by Candida albicans. J Low Genit Tract Dis. 2020;24(1):48-52. doi: 10.1097/LGT.0000000000000496, PMID 31860575.
9. Purwati S, Dewi SS, Prastyanto ME. Keanekaragaman Bakteri dan Jamur Pada Sekret Vagina Pasien Keputihan di RSUP dr. Kariadi Semarang. 2017;12:67.
10. Parwati NW, Djamil M. Vaginal discharge caused candida albicans: laboratory study. Int J Allied M Edical Sci Clin Res (IJAMSCR). 2019;7(1):91-5.
11. Zubair dkk. Studi Etnobotani Tumbuhan Obat Pada Masyarakat Kaili Rai Di Desa Wombo Kecamatan Tanantovea Kabupaten Donggala Sulawesi Tengah. Biocelebes. 2019;13(2):182-94.
12. Tahongai PS. (Kleinhovia hospita L.): review sebuah tumbuhan obat Dari Kalimantan timur. J Tumbuhan Obat Indones. 2016;9(1).
13. Zhou C, Zou L, Gan L, Cao Y, Kleinhospitines AÀD. New cycloartane triterpenoid alkaloids from Kleinhovia hospita. 2013;5:1813-6.
14. Komang A, Hambat D, DAYA HAMBAT CP. Pertumbuhan Candida albicans DAN DAYA BUNUH Candida albicans EKSTRAK DAUN KEMANGI (Ocimum sanctum l.). 2017;78-83.
2. Dhirah U, Anwar C. Promosi kesehatan tentang Flour Albus serta Penanganannya di sma negeri 8 Banda Aceh. J UuiAcId. 2020;2(1):38-40.
3. World Health Organization. Sex Transm Infect. 2016:2016-21.
4. Denning DW, Kneale M, Sobel JD, Rautemaa-richardson R. Review Global burden of recurrent vulvovaginal candidiasis: a systematic review. Lancet Infect Dis. 2018;3099(18):1-9. doi: 10.1016/S1473-3099(18)30103-8.
5. Ramasamy SL SC. Sexually Transmitted Disease and Leukorrhea in a Rural South Asian Himalayan Community?: A Study of Perceptions and Barriers to Treatment. Women’s health and wellness. 2019;5(2):1-7.
6. Azizah N, Widiawati I. Karakteristik remaja Putri dengan kejadian Keputihan di Smk Muhammadiyah kudus. Januari. 2015;6(1):57-78.
7. Handayani AM, Rochmah FZ, Firdaus RA, Cair Sabun. Granat putih ”(Punica granatum) sebagai obat Keputihan; 2017. p. 171-6.
8. Collins LM, Moore R, Sobel JD. Prognosis and long-term outcome of women with idiopathic recurrent vulvovaginal candidiasis caused by Candida albicans. J Low Genit Tract Dis. 2020;24(1):48-52. doi: 10.1097/LGT.0000000000000496, PMID 31860575.
9. Purwati S, Dewi SS, Prastyanto ME. Keanekaragaman Bakteri dan Jamur Pada Sekret Vagina Pasien Keputihan di RSUP dr. Kariadi Semarang. 2017;12:67.
10. Parwati NW, Djamil M. Vaginal discharge caused candida albicans: laboratory study. Int J Allied M Edical Sci Clin Res (IJAMSCR). 2019;7(1):91-5.
11. Zubair dkk. Studi Etnobotani Tumbuhan Obat Pada Masyarakat Kaili Rai Di Desa Wombo Kecamatan Tanantovea Kabupaten Donggala Sulawesi Tengah. Biocelebes. 2019;13(2):182-94.
12. Tahongai PS. (Kleinhovia hospita L.): review sebuah tumbuhan obat Dari Kalimantan timur. J Tumbuhan Obat Indones. 2016;9(1).
13. Zhou C, Zou L, Gan L, Cao Y, Kleinhospitines AÀD. New cycloartane triterpenoid alkaloids from Kleinhovia hospita. 2013;5:1813-6.
14. Komang A, Hambat D, DAYA HAMBAT CP. Pertumbuhan Candida albicans DAN DAYA BUNUH Candida albicans EKSTRAK DAUN KEMANGI (Ocimum sanctum l.). 2017;78-83.
