Alteration Of Hernia Susceptible Genes In Colorectal, Stomach And Testicular Cancers
Corresponding Author(s) : Srikanth Pallothu
Srikanthpallothu@gmail.com
International Journal of Allied Medical Sciences and Clinical Research,
Vol. 9 No. 3 (2021): 2021 Volume - 9 Issue - 3
Abstract
Background:There are reports indicating the association of colon carcinoma with inguinal hernia. Four novel Hernia susceptible genes have been identified in a genome-wide association study. Evaluating the status of hernia susceptible genes in colorectal, stomach and testicular cancers will provide some insights about the co-occurrences or severity of cancer. Current study was designed to evaluate the expression of hernia susceptible genes and their proteins in colon, stomach and testicular cancers and their respective normal tissues and determine their interacting proteins.
Methods:University of California Santa Cruz (UCSC) Xena browser of TCGA TARGET GTExdatabase was used for determining the mRNA expression of herniasusceptible genes EFEMP1, WT1, EBF2 and ADAMTS6 in primary tumour of colorectal, stomach and testicular cancers and their respective normal tissues. Utilizing the Human Protein Atlas (HPA) database, differences in the expression of proteins encoded by hernia susceptible genes were determined normal tissues and the primary tumours of colon, stomach, and testis. STRING, protein-protein interaction network analysis was used to evaluate interaction protein partners of hernia susceptible genes.
Results:In the colorectal cancerprimary tumour tissue EFEMP1 and EBF2 were significantly downregulated,and WT was significantly upregulated compared to normal colon tissue. There was no change in the expression of ADAMTS6.In stomach cancers mRNA of WT1, EBF2 and ADAMTS6 were significantly upregulated and EFEMP1 was downregulated in primary tumours compared to normal stomach. In testicular cancers, mRNA expression of EFEMP1 was upregulated and WT1, EBF2 and ADAMTS6 were downregulated compared to normal testis.Protein-protein interaction studies revealed that all the four hernia susceptible genes interacted with the proteins associated with tissue remodelling and immune response. Conclusion:Our results showed that hernia susceptible genes were differentially expressed in colorectal, stomach and testicular cancerssuggesting their functional significance in these cancer patients and some of these may serve as markers in the treatment intervention.
Keywords
Colorectal
Stomach And Testicular Cancers
1.
Jyothsna Bollu, Srikanth Pallothu. Alteration Of Hernia Susceptible Genes In Colorectal, Stomach And Testicular Cancers. Int. J. of Allied Med. Sci. and Clin. Res. [Internet]. 2021 Sep. 6 [cited 2025 Jul. 13];9(3):571-82. Available from: https://ijamscr.com/ijamscr/article/view/1072
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References
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