Alteration of Hernia Susceptible Genes in Colorectal, Stomach and Testicular Cancers
Corresponding Author(s) : Srikanth Pallothu
Srikanthpallothu@gmail.com
International Journal of Allied Medical Sciences and Clinical Research,
Vol. 9 No. 3 (2021): 2021 Volume - 9 Issue - 3
Abstract
Background:There are reports indicating the association of colon carcinoma with inguinal hernia. Four novel Hernia susceptible genes have been identified in a genome-wide association study. Evaluating the status of hernia susceptible genes in colorectal, stomach and testicular cancers will provide some insights about the co-occurrences or severity of cancer. Current study was designed to evaluate the expression of hernia susceptible genes and their proteins in colon, stomach and testicular cancers and their respective normal tissues and determine their interacting proteins.
Methods:University of California Santa Cruz (UCSC) Xena browser of TCGA TARGET GTExdatabase was used for determining the mRNA expression of herniasusceptible genes EFEMP1, WT1, EBF2 and ADAMTS6 in primary tumour of colorectal, stomach and testicular cancers and their respective normal tissues. Utilizing the Human Protein Atlas (HPA) database, differences in the expression of proteins encoded by hernia susceptible genes were determined normal tissues and the primary tumours of colon, stomach, and testis. STRING, protein-protein interaction network analysis was used to evaluate interaction protein partners of hernia susceptible genes.
Results:In the colorectal cancerprimary tumour tissue EFEMP1 and EBF2 were significantly downregulated,and WT was significantly upregulated compared to normal colon tissue. There was no change in the expression of ADAMTS6.In stomach cancers mRNA of WT1, EBF2 and ADAMTS6 were significantly upregulated and EFEMP1 was downregulated in primary tumours compared to normal stomach. In testicular cancers, mRNA expression of EFEMP1 was upregulated and WT1, EBF2 and ADAMTS6 were downregulated compared to normal testis.Protein-protein interaction studies revealed that all the four hernia susceptible genes interacted with the proteins associated with tissue remodelling and immune response. Conclusion:Our results showed that hernia susceptible genes were differentially expressed in colorectal, stomach and testicular cancerssuggesting their functional significance in these cancer patients and some of these may serve as markers in the treatment intervention.
Keywords
Colorectal
Stomach And Testicular Cancers
1.
Jyothsna Bollu, Srikanth Pallothu. Alteration of Hernia Susceptible Genes in Colorectal, Stomach and Testicular Cancers. Int. J. of Allied Med. Sci. and Clin. Res. [Internet]. 2021 Sep. 6 [cited 2026 Apr. 29];9(3):571-82. Available from: https://ijamscr.com/ijamscr/article/view/1072
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References
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[1]. Allegra, C. J., G. Yothers, M. J. O'Connell, S. Sharif, L. H. Colangelo, S. H. Lopa, N. J. Petrelli, R. M. Goldberg, J. N. Atkins, T. E. Seay, L. Fehrenbacher, S. O'Reilly, L. Chu, C. A. Azar, and N. Wolmark. 2009. 'Initial safety report of NSABP C-08: A randomized phase III study of modified FOLFOX6 with or without bevacizumab for the adjuvant treatment of patients with stage II or III colon cancer', J Clin Oncol, 27: 3385-90.
[2]. Antoniou, G. A., G. S. Georgiadis, S. A. Antoniou, F. A. Granderath, A. D. Giannoukas, and M. K. Lazarides. 2011. 'Abdominal aortic aneurysm and abdominal wall hernia as manifestations of a connective tissue disorder', J Vasc Surg, 54: 1175-81.
[3]. Antoniou, G. A., I. K. Tentes, S. A. Antoniou, C. Simopoulos, and M. K. Lazarides. 2011. 'Matrix metalloproteinase imbalance in inguinal hernia formation', J Invest Surg, 24: 145-50.
[4]. Baudry, D., M. Faussillon, M. O. Cabanis, M. Rigolet, J. M. Zucker, C. Patte, S. Sarnacki, L. Boccon-Gibod, C. Junien, and C. Jeanpierre. 2002. 'Changes in WT1 splicing are associated with a specific gene expression profile in Wilms' tumour', Oncogene, 21: 5566-73.
[5]. Bendavid, R. 2004. 'The unified theory of hernia formation', Hernia, 8: 171-6.
[6]. Birolini, C., E.M. Utiyama, A.J. Rodrigues, and D. Birolini. 1998. 'The association of inguinal hernias and colon cancer. A technical strategy based upon three patients.', Hernia, 2: 139-43.
[7]. Bollu J, Sunkara VR , and Vankadara S. 2020. 'Study of Demographic, Risk factors and Evidence based Hernia repair and its
[8]. Management in Adults in Tertiary care Hospital ', International Journal of Allied Medical Sciences and Clinical Research, 8: 781-88.
[9]. Bray, F., M. Laversanne, E. Weiderpass, and I. Soerjomataram. 2021. 'The ever-increasing importance of cancer as a leading cause of premature death worldwide', Cancer, 127: 3029-30.
[10]. Brocker, C. N., V. Vasiliou, and D. W. Nebert. 2009. 'Evolutionary divergence and functions of the ADAM and ADAMTS gene families', Hum Genomics, 4: 43-55.
[11]. Carmona, R., A. Canete, E. Cano, L. Ariza, A. Rojas, and R. Munoz-Chapuli. 2016. 'Conditional deletion of WT1 in the septum transversum mesenchyme causes congenital diaphragmatic hernia in mice', Elife, 5.
[12]. Casanova, A. B., E. N. Trindade, and M. R. Trindade. 2009. 'Collagen in the transversalis fascia of patients with indirect inguinal hernia: a case-control study', Am J Surg, 198: 1-5.
[13]. Coldman, A. J., J. M. Elwood, and R. P. Gallagher. 1982. 'Sports activities and risk of testicular cancer', Br J Cancer, 46: 749-56.
[14]. Collot, T., J. D. Fumet, Q. Klopfenstein, J. Vincent, L. Bengrine, and F. Ghiringhelli. 2018. 'Bevacizumab-based Chemotherapy for Poorly-differentiated Neuroendocrine Tumors', Anticancer Res, 38: 5963-68.
[15]. Cook, M. B., O. Akre, D. Forman, M. P. Madigan, L. Richiardi, and K. A. McGlynn. 2010. 'A systematic review and meta-analysis of perinatal variables in relation to the risk of testicular cancer--experiences of the son', Int J Epidemiol, 39: 1605-18.
[16]. Davis, WC., and FC. Jackson. 1968. 'Inguinal Hernia and Colon Carcinoma', CA: A Cancer Journal for Clinicians, 18: 143-45.
[17]. Dingemann, J., T. Doi, E. Ruttenstock, and P. Puri. 2011. 'Expression of the Wilm's tumor gene WT1 during diaphragmatic development in the nitrofen model for congenital diaphragmatic hernia', Pediatr Surg Int, 27: 159-63.
[18]. Eriksen, M., and O. Bulut. 2014. 'Chemotherapy-induced enterocutaneous fistula after perineal hernia repair using a biological mesh: a case report', Int Med Case Rep J, 7: 11-3.
[19]. Eveno, C., G. Passot, D. Goere, P. Soyer, E. Gayat, O. Glehen, D. Elias, and M. Pocard. 2014. 'Bevacizumab doubles the early postoperative complication rate after cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (HIPEC) for peritoneal carcinomatosis of colorectal origin', Ann Surg Oncol, 21: 1792-800.
[20]. Gallagher, R. P., S. Huchcroft, N. Phillips, G. B. Hill, A. J. Coldman, C. Coppin, and T. Lee. 1995. 'Physical activity, medical history, and risk of testicular cancer (Alberta and British Columbia, Canada)', Cancer Causes Control, 6: 398-406.
[21]. Giakoustidis, A., D. Morrison, K. Neofytou, D. Giakoustidis, and S. Mudan. 2014. 'Emergency open incarcerated hernia repair with a biological mesh in a patient with colorectal liver metastasis receiving chemotherapy and bevacizumab uncomplicated wound healing', Case Rep Emerg Med, 2014: 848030.
[22]. Glanze WD, Anderson KN, Anderson LE, Urdang L, and Swallow HH. 1986. 'Mosby Medical and Nursing Dictionary', The CV Mosby Company, Saint Louis. 2nd ED: 528.
[23]. Goldman, M. J., B. Craft, M. Hastie, K. Repecka, F. McDade, A. Kamath, A. Banerjee, Y. Luo, D. Rogers, A. N. Brooks, J. Zhu, and D. Haussler. 2020. 'Visualizing and interpreting cancer genomics data via the Xena platform', Nat Biotechnol, 38: 675-78.
[24]. Group, United Kingdom Testicular Cancer Study. 1994. 'Aetiology of testicular cancer: association with congenital abnormalities, age at puberty, infertility, and exercise. United Kingdom Testicular Cancer Study Group', BMJ, 308: 1393-9.
[25]. Hajibandeh, S., S. Hajibandeh, A. Sreh, A. Khan, D. Subar, and L. Jones. 2017. 'Laparoscopic versus open umbilical or paraumbilical hernia repair: a systematic review and meta-analysis', Hernia, 21: 905-16.
[26]. Hapani, S., D. Chu, and S. Wu. 2009. 'Risk of gastrointestinal perforation in patients with cancer treated with bevacizumab: a meta-analysis', Lancet Oncol, 10: 559-68.
[27]. HerniaSurge, Group. 2018. 'International guidelines for groin hernia management', Hernia, 22: 1-165.
[28]. Honecker, F., J. Aparicio, D. Berney, J. Beyer, C. Bokemeyer, R. Cathomas, N. Clarke, G. Cohn-Cedermark, G. Daugaard, K. P. Dieckmann, K. Fizazi, S. Fossa, J. R. Germa-Lluch, P. Giannatempo, J. A. Gietema, S. Gillessen, H. S. Haugnes, A. Heidenreich, K. Hemminki, R. Huddart, M. A. S. Jewett, F. Joly, J. Lauritsen, A. Lorch, A. Necchi, N. Nicolai, C. Oing, J. Oldenburg, D. Ondrus, A. Papachristofilou, T. Powles, A. Sohaib, O. Stahl, T. Tandstad, G. Toner, and A. Horwich. 2018. 'ESMO Consensus Conference on testicular germ cell cancer: diagnosis, treatment and follow-up', Ann Oncol, 29: 1658-86.
[29]. Jenkins, J. T., and P. J. O'Dwyer. 2008. 'Inguinal hernias', BMJ, 336: 269-72.
[30]. Jha S, and Pankaj D. 2020. 'A study to assess the prevalence and risk factors of
[31]. Inguinal hernia', International Journal of Surgery Science, 4: 330-32.
[32]. Jorgenson, E., N. Makki, L. Shen, D. C. Chen, C. Tian, W. L. Eckalbar, D. Hinds, N. Ahituv, and A. Avins. 2015. 'A genome-wide association study identifies four novel susceptibility loci underlying inguinal hernia', Nat Commun, 6: 10130.
[33]. Kingsnorth, A., and K. LeBlanc. 2003. 'Hernias: inguinal and incisional', Lancet, 362: 1561-71.
[34]. Klenotic, P. A., F. L. Munier, L. Y. Marmorstein, and B. Anand-Apte. 2004. 'Tissue inhibitor of metalloproteinases-3 (TIMP-3) is a binding partner of epithelial growth factor-containing fibulin-like extracellular matrix protein 1 (EFEMP1). Implications for macular degenerations', J Biol Chem, 279: 30469-73.
[35]. Kulacoglu, H., and F. Kockerling. 2019. 'Hernia and Cancer: The Points Where the Roads Intersect', Front Surg, 6: 19.
[36]. Laschke, M. W., J. M. Haufel, J. Roller, H. Schorr, and M. D. Menger. 2009. 'Rapamycin, but not cyclosporine A, inhibits vascularization and incorporation of implanted surgical meshes', Transpl Int, 22: 654-62.
[37]. Law, B. K. 2005. 'Rapamycin: an anti-cancer immunosuppressant?', Crit Rev Oncol Hematol, 56: 47-60.
[38]. Li, X., Y. Deng, W. Tang, Q. Sun, Y. Chen, C. Yang, B. Yan, Y. Wang, J. Wang, S. Wang, F. Yang, Y. Ding, G. Zhao, and G. Cao. 2018. 'Urban-Rural Disparity in Cancer Incidence, Mortality, and Survivals in Shanghai, China, During 2002 and 2015', Front Oncol, 8: 579.
[39]. Ma, X., Y. Liu, Q. Wang, Y. Chen, M. Liu, X. Li, R. Xiang, Y. Wei, Y. Duan, and J. Han. 2015. 'Tamoxifen induces the development of hernia in mice by activating MMP-2 and MMP-13 expression', Biochim Biophys Acta, 1852: 1038-48.
[40]. Mai, P. L., M. Friedlander, K. Tucker, K. A. Phillips, D. Hogg, M. A. Jewett, R. Lohynska, G. Daugaard, S. Richard, C. Bonaiti-Pellie, A. Heidenreich, P. Albers, I. Bodrogi, L. Geczi, E. Olah, P. A. Daly, P. Guilford, S. D. Fossa, K. Heimdal, L. Liubchenko, S. A. Tjulandin, H. Stoll, W. Weber, D. F. Easton, zD. Dudakia, R. Huddart, M. R. Stratton, L. Einhorn, L. Korde, K. L. Nathanson, D. T. Bishop, E. A. Rapley, and M. H. Greene. 2010. 'The International Testicular Cancer Linkage Consortium: a clinicopathologic descriptive analysis of 461 familial malignant testicular germ cell tumor kindred', Urol Oncol, 28: 492-9.
[41]. McLaughlin, P. J., B. Bakall, J. Choi, Z. Liu, T. Sasaki, E. C. Davis, A. D. Marmorstein, and L. Y. Marmorstein. 2007. 'Lack of fibulin-3 causes early aging and herniation, but not macular degeneration in mice', Hum Mol Genet, 16: 3059-70.
[42]. Mimatsu, K., H. Kano, T. Oida, A. Kawasaki, N. Fukino, K. Kida, Y. Kuboi, and S. Amano. 2014. 'Gastric Cancer Arising from an Upside-Down Stomach through a Paraesophageal Hiatal Hernia', Case Rep Gastroenterol, 8: 107-14.
[43]. Mizuno, H., H. Nagai, S. Maeda, H. Miyake, Y. Yoshioka, and N. Yuasa. 2019. 'Incarcerated sigmoid colon cancer in an inguinal hernia sac associated with an abdominal wall abscess: a case report', Surg Case Rep, 5: 189.
[44]. Morrison, A. S. 1976. 'Cryptorchidism, hernia, and cancer of the testis', J Natl Cancer Inst, 56: 731-3.
[45]. Ondrusova, M., and D. Ondrus. 2009. 'Epidemiological features of testicular cancer in the Slovak Republic--retrospective study', Klin Onkol, 22: 52-7.
[46]. Pottern, L. M., L. M. Brown, R. N. Hoover, N. Javadpour, K. J. O'Connell, R. E. Stutzman, and W. A. Blattner. 1985. 'Testicular cancer risk among young men: role of cryptorchidism and inguinal hernia', J Natl Cancer Inst, 74: 377-81.
[47]. Primatesta, P., and M. J. Goldacre. 1996. 'Inguinal hernia repair: incidence of elective and emergency surgery, readmission and mortality', Int J Epidemiol, 25: 835-9.
[48]. Qu, C. Y., Y. Zheng, M. Zhou, Y. Zhang, F. Shen, J. Cao, and L. M. Xu. 2015. 'Value of bevacizumab in treatment of colorectal cancer: A meta-analysis', World J Gastroenterol, 21: 5072-80.
[49]. Ramjist, J. K., F. Dossa, T. A. Stukel, D. R. Urbach, L. Fu, and N. N. Baxter. 2019. 'Reoperation for inguinal hernia recurrence in Ontario: a population-based study', Hernia, 23: 647-54.
[50]. Rao S S, Singh P, Gupta D, and Narang R. 2016. 'Clinicoepidemiologic profile of inguinal hernia in rural medical college in central India', J Mahatma Gandhi Inst Med Sci, 21.
[51]. Rong, Y., L. Cheng, H. Ning, J. Zou, Y. Zhang, F. Xu, L. Liu, Z. Chang, and X. Y. Fu. 2006. 'Wilms' tumor 1 and signal transducers and activators of transcription 3 synergistically promote cell proliferation: a possible mechanism in sporadic Wilms' tumor', Cancer Res, 66: 8049-57.
[52]. Rovito, M. J., S. Taylor, R. Lockwood, W. B. Adams, and M. Craycraft. 2020. 'Testicular Cancer Incidence and Mortality Within Rural and Urban Regions', J Adolesc Young Adult Oncol, 9: 202-07.
[53]. Salemans, P. B., G. F. Vles, S. A. Fransen, and R. M. Smeenk. 2013. 'Sigmoid carcinoma in an inguinal hernia: a blessing in disguise?', Case Rep Surg, 2013: 314394.
[54]. Schmidt, L., S. Oberg, K. Andresen, and J. Rosenberg. 2018. 'Recurrence Rates After Repair of Inguinal Hernia in Women: A Systematic Review', JAMA Surg, 153: 1135-42.
[55]. Shapira, S. N., H. W. Lim, S. Rajakumari, A. P. Sakers, J. Ishibashi, M. J. Harms, K. J. Won, and P. Seale. 2017. 'EBF2 transcriptionally regulates brown adipogenesis via the histone reader DPF3 and the BAF chromatin remodeling complex', Genes Dev, 31: 660-73.
[56]. Sung, H., J. Ferlay, R. L. Siegel, M. Laversanne, I. Soerjomataram, A. Jemal, and F. Bray. 2021. 'Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries', CA Cancer J Clin, 71: 209-49.
[57]. Swerdlow, A. J., S. R. Huttly, and P. G. Smith. 1987. 'Testicular cancer and antecedent diseases', Br J Cancer, 55: 97-103.
[58]. Szklarczyk, D., A. L. Gable, D. Lyon, A. Junge, S. Wyder, J. Huerta-Cepas, M. Simonovic, N. T. Doncheva, J. H. Morris, P. Bork, L. J. Jensen, and C. V. Mering. 2019. 'STRING v11: protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets', Nucleic Acids Res, 47: D607-D13.
[59]. Terezis NL., Davis WC., and Jackson FC. 1963. 'Carcinoma of the colon associated with Inguinal Hernia', The New England Journal of Medicine, 268: 774-76.
[60]. Uhlen, M., L. Fagerberg, B. M. Hallstrom, C. Lindskog, P. Oksvold, A. Mardinoglu, A. Sivertsson, C. Kampf, E. Sjostedt, A. Asplund, I. Olsson, K. Edlund, E. Lundberg, S. Navani, C. A. Szigyarto, J. Odeberg, D. Djureinovic, J. O. Takanen, S. Hober, T. Alm, P. H. Edqvist, H. Berling, H. Tegel, J. Mulder, J. Rockberg, P. Nilsson, J. M. Schwenk, M. Hamsten, K. von Feilitzen, M. Forsberg, L. Persson, F. Johansson, M. Zwahlen, G. von Heijne, J. Nielsen, and F. Ponten. 2015. 'Proteomics. Tissue-based map of the human proteome', Science, 347: 1260419.
[61]. Venclauskas, L., M. Jokubauskas, J. Zilinskas, K. Zviniene, and M. Kiudelis. 2017. 'Long-term follow-up results of umbilical hernia repair', Wideochir Inne Tech Maloinwazyjne, 12: 350-56.
[62]. Venook, A. P., D. Niedzwiecki, H. J. Lenz, F. Innocenti, B. Fruth, J. A. Meyerhardt, D. Schrag, C. Greene, B. H. O'Neil, J. N. Atkins, S. Berry, B. N. Polite, E. M. O'Reilly, R. M. Goldberg, H. S. Hochster, R. L. Schilsky, M. M. Bertagnolli, A. B. El-Khoueiry, P. Watson, A. B. Benson, 3rd, D. L. Mulkerin, R. J. Mayer, and C. Blanke. 2017. 'Effect of First-Line Chemotherapy Combined With Cetuximab or Bevacizumab on Overall Survival in Patients With KRAS Wild-Type Advanced or Metastatic Colorectal Cancer: A Randomized Clinical Trial', JAMA, 317: 2392-401.
[63]. Xiao, W. H., X. L. Qu, X. M. Li, Y. L. Sun, H. X. Zhao, S. Wang, and X. Zhou. 2015. 'Identification of commonly dysregulated genes in colorectal cancer by integrating analysis of RNA-Seq data and qRT-PCR validation', Cancer Gene Ther, 22: 278-84.
[64]. Zahnd, W. E., M. M. Davis, J. S. Rotter, R. C. Vanderpool, C. K. Perry, J. Shannon, L. K. Ko, S. B. Wheeler, C. L. Odahowski, P. E. Farris, and J. M. Eberth. 2019. 'Rural-urban differences in financial burden among cancer survivors: an analysis of a nationally representative survey', Support Care Cancer, 27: 4779-86.
[65]. Zahnd, W. E., A. S. James, W. D. Jenkins, S. R. Izadi, A. J. Fogleman, D. E. Steward, G. A. Colditz, and L. Brard. 2018. 'Rural-Urban Differences in Cancer Incidence and Trends in the United States', Cancer Epidemiol Biomarkers Prev, 27: 1265-74.
[66]. Zhang, H., Z. Huang, X. Zou, and T. Liu. 2016. 'Bevacizumab and wound-healing complications: a systematic review and meta-analysis of randomized controlled trials', Oncotarget, 7: 82473-81.
[67]. Zhou, Y. H., Y. Hu, L. Yu, C. Ke, Co, H. Hsu, Z. Li, A. T. Di Donato, A. Chaturbedi, J. W. Hwang, E. R. Siegel, and M. E. Linskey. 2016. 'Weaponizing human EGF-containing fibulin-like extracellular matrix protein 1 (EFEMP1) for 21(st) century cancer therapeutics', Oncoscience, 3: 208-19.
References
[1]. Allegra, C. J., G. Yothers, M. J. O'Connell, S. Sharif, L. H. Colangelo, S. H. Lopa, N. J. Petrelli, R. M. Goldberg, J. N. Atkins, T. E. Seay, L. Fehrenbacher, S. O'Reilly, L. Chu, C. A. Azar, and N. Wolmark. 2009. 'Initial safety report of NSABP C-08: A randomized phase III study of modified FOLFOX6 with or without bevacizumab for the adjuvant treatment of patients with stage II or III colon cancer', J Clin Oncol, 27: 3385-90.
[2]. Antoniou, G. A., G. S. Georgiadis, S. A. Antoniou, F. A. Granderath, A. D. Giannoukas, and M. K. Lazarides. 2011. 'Abdominal aortic aneurysm and abdominal wall hernia as manifestations of a connective tissue disorder', J Vasc Surg, 54: 1175-81.
[3]. Antoniou, G. A., I. K. Tentes, S. A. Antoniou, C. Simopoulos, and M. K. Lazarides. 2011. 'Matrix metalloproteinase imbalance in inguinal hernia formation', J Invest Surg, 24: 145-50.
[4]. Baudry, D., M. Faussillon, M. O. Cabanis, M. Rigolet, J. M. Zucker, C. Patte, S. Sarnacki, L. Boccon-Gibod, C. Junien, and C. Jeanpierre. 2002. 'Changes in WT1 splicing are associated with a specific gene expression profile in Wilms' tumour', Oncogene, 21: 5566-73.
[5]. Bendavid, R. 2004. 'The unified theory of hernia formation', Hernia, 8: 171-6.
[6]. Birolini, C., E.M. Utiyama, A.J. Rodrigues, and D. Birolini. 1998. 'The association of inguinal hernias and colon cancer. A technical strategy based upon three patients.', Hernia, 2: 139-43.
[7]. Bollu J, Sunkara VR , and Vankadara S. 2020. 'Study of Demographic, Risk factors and Evidence based Hernia repair and its
[8]. Management in Adults in Tertiary care Hospital ', International Journal of Allied Medical Sciences and Clinical Research, 8: 781-88.
[9]. Bray, F., M. Laversanne, E. Weiderpass, and I. Soerjomataram. 2021. 'The ever-increasing importance of cancer as a leading cause of premature death worldwide', Cancer, 127: 3029-30.
[10]. Brocker, C. N., V. Vasiliou, and D. W. Nebert. 2009. 'Evolutionary divergence and functions of the ADAM and ADAMTS gene families', Hum Genomics, 4: 43-55.
[11]. Carmona, R., A. Canete, E. Cano, L. Ariza, A. Rojas, and R. Munoz-Chapuli. 2016. 'Conditional deletion of WT1 in the septum transversum mesenchyme causes congenital diaphragmatic hernia in mice', Elife, 5.
[12]. Casanova, A. B., E. N. Trindade, and M. R. Trindade. 2009. 'Collagen in the transversalis fascia of patients with indirect inguinal hernia: a case-control study', Am J Surg, 198: 1-5.
[13]. Coldman, A. J., J. M. Elwood, and R. P. Gallagher. 1982. 'Sports activities and risk of testicular cancer', Br J Cancer, 46: 749-56.
[14]. Collot, T., J. D. Fumet, Q. Klopfenstein, J. Vincent, L. Bengrine, and F. Ghiringhelli. 2018. 'Bevacizumab-based Chemotherapy for Poorly-differentiated Neuroendocrine Tumors', Anticancer Res, 38: 5963-68.
[15]. Cook, M. B., O. Akre, D. Forman, M. P. Madigan, L. Richiardi, and K. A. McGlynn. 2010. 'A systematic review and meta-analysis of perinatal variables in relation to the risk of testicular cancer--experiences of the son', Int J Epidemiol, 39: 1605-18.
[16]. Davis, WC., and FC. Jackson. 1968. 'Inguinal Hernia and Colon Carcinoma', CA: A Cancer Journal for Clinicians, 18: 143-45.
[17]. Dingemann, J., T. Doi, E. Ruttenstock, and P. Puri. 2011. 'Expression of the Wilm's tumor gene WT1 during diaphragmatic development in the nitrofen model for congenital diaphragmatic hernia', Pediatr Surg Int, 27: 159-63.
[18]. Eriksen, M., and O. Bulut. 2014. 'Chemotherapy-induced enterocutaneous fistula after perineal hernia repair using a biological mesh: a case report', Int Med Case Rep J, 7: 11-3.
[19]. Eveno, C., G. Passot, D. Goere, P. Soyer, E. Gayat, O. Glehen, D. Elias, and M. Pocard. 2014. 'Bevacizumab doubles the early postoperative complication rate after cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (HIPEC) for peritoneal carcinomatosis of colorectal origin', Ann Surg Oncol, 21: 1792-800.
[20]. Gallagher, R. P., S. Huchcroft, N. Phillips, G. B. Hill, A. J. Coldman, C. Coppin, and T. Lee. 1995. 'Physical activity, medical history, and risk of testicular cancer (Alberta and British Columbia, Canada)', Cancer Causes Control, 6: 398-406.
[21]. Giakoustidis, A., D. Morrison, K. Neofytou, D. Giakoustidis, and S. Mudan. 2014. 'Emergency open incarcerated hernia repair with a biological mesh in a patient with colorectal liver metastasis receiving chemotherapy and bevacizumab uncomplicated wound healing', Case Rep Emerg Med, 2014: 848030.
[22]. Glanze WD, Anderson KN, Anderson LE, Urdang L, and Swallow HH. 1986. 'Mosby Medical and Nursing Dictionary', The CV Mosby Company, Saint Louis. 2nd ED: 528.
[23]. Goldman, M. J., B. Craft, M. Hastie, K. Repecka, F. McDade, A. Kamath, A. Banerjee, Y. Luo, D. Rogers, A. N. Brooks, J. Zhu, and D. Haussler. 2020. 'Visualizing and interpreting cancer genomics data via the Xena platform', Nat Biotechnol, 38: 675-78.
[24]. Group, United Kingdom Testicular Cancer Study. 1994. 'Aetiology of testicular cancer: association with congenital abnormalities, age at puberty, infertility, and exercise. United Kingdom Testicular Cancer Study Group', BMJ, 308: 1393-9.
[25]. Hajibandeh, S., S. Hajibandeh, A. Sreh, A. Khan, D. Subar, and L. Jones. 2017. 'Laparoscopic versus open umbilical or paraumbilical hernia repair: a systematic review and meta-analysis', Hernia, 21: 905-16.
[26]. Hapani, S., D. Chu, and S. Wu. 2009. 'Risk of gastrointestinal perforation in patients with cancer treated with bevacizumab: a meta-analysis', Lancet Oncol, 10: 559-68.
[27]. HerniaSurge, Group. 2018. 'International guidelines for groin hernia management', Hernia, 22: 1-165.
[28]. Honecker, F., J. Aparicio, D. Berney, J. Beyer, C. Bokemeyer, R. Cathomas, N. Clarke, G. Cohn-Cedermark, G. Daugaard, K. P. Dieckmann, K. Fizazi, S. Fossa, J. R. Germa-Lluch, P. Giannatempo, J. A. Gietema, S. Gillessen, H. S. Haugnes, A. Heidenreich, K. Hemminki, R. Huddart, M. A. S. Jewett, F. Joly, J. Lauritsen, A. Lorch, A. Necchi, N. Nicolai, C. Oing, J. Oldenburg, D. Ondrus, A. Papachristofilou, T. Powles, A. Sohaib, O. Stahl, T. Tandstad, G. Toner, and A. Horwich. 2018. 'ESMO Consensus Conference on testicular germ cell cancer: diagnosis, treatment and follow-up', Ann Oncol, 29: 1658-86.
[29]. Jenkins, J. T., and P. J. O'Dwyer. 2008. 'Inguinal hernias', BMJ, 336: 269-72.
[30]. Jha S, and Pankaj D. 2020. 'A study to assess the prevalence and risk factors of
[31]. Inguinal hernia', International Journal of Surgery Science, 4: 330-32.
[32]. Jorgenson, E., N. Makki, L. Shen, D. C. Chen, C. Tian, W. L. Eckalbar, D. Hinds, N. Ahituv, and A. Avins. 2015. 'A genome-wide association study identifies four novel susceptibility loci underlying inguinal hernia', Nat Commun, 6: 10130.
[33]. Kingsnorth, A., and K. LeBlanc. 2003. 'Hernias: inguinal and incisional', Lancet, 362: 1561-71.
[34]. Klenotic, P. A., F. L. Munier, L. Y. Marmorstein, and B. Anand-Apte. 2004. 'Tissue inhibitor of metalloproteinases-3 (TIMP-3) is a binding partner of epithelial growth factor-containing fibulin-like extracellular matrix protein 1 (EFEMP1). Implications for macular degenerations', J Biol Chem, 279: 30469-73.
[35]. Kulacoglu, H., and F. Kockerling. 2019. 'Hernia and Cancer: The Points Where the Roads Intersect', Front Surg, 6: 19.
[36]. Laschke, M. W., J. M. Haufel, J. Roller, H. Schorr, and M. D. Menger. 2009. 'Rapamycin, but not cyclosporine A, inhibits vascularization and incorporation of implanted surgical meshes', Transpl Int, 22: 654-62.
[37]. Law, B. K. 2005. 'Rapamycin: an anti-cancer immunosuppressant?', Crit Rev Oncol Hematol, 56: 47-60.
[38]. Li, X., Y. Deng, W. Tang, Q. Sun, Y. Chen, C. Yang, B. Yan, Y. Wang, J. Wang, S. Wang, F. Yang, Y. Ding, G. Zhao, and G. Cao. 2018. 'Urban-Rural Disparity in Cancer Incidence, Mortality, and Survivals in Shanghai, China, During 2002 and 2015', Front Oncol, 8: 579.
[39]. Ma, X., Y. Liu, Q. Wang, Y. Chen, M. Liu, X. Li, R. Xiang, Y. Wei, Y. Duan, and J. Han. 2015. 'Tamoxifen induces the development of hernia in mice by activating MMP-2 and MMP-13 expression', Biochim Biophys Acta, 1852: 1038-48.
[40]. Mai, P. L., M. Friedlander, K. Tucker, K. A. Phillips, D. Hogg, M. A. Jewett, R. Lohynska, G. Daugaard, S. Richard, C. Bonaiti-Pellie, A. Heidenreich, P. Albers, I. Bodrogi, L. Geczi, E. Olah, P. A. Daly, P. Guilford, S. D. Fossa, K. Heimdal, L. Liubchenko, S. A. Tjulandin, H. Stoll, W. Weber, D. F. Easton, zD. Dudakia, R. Huddart, M. R. Stratton, L. Einhorn, L. Korde, K. L. Nathanson, D. T. Bishop, E. A. Rapley, and M. H. Greene. 2010. 'The International Testicular Cancer Linkage Consortium: a clinicopathologic descriptive analysis of 461 familial malignant testicular germ cell tumor kindred', Urol Oncol, 28: 492-9.
[41]. McLaughlin, P. J., B. Bakall, J. Choi, Z. Liu, T. Sasaki, E. C. Davis, A. D. Marmorstein, and L. Y. Marmorstein. 2007. 'Lack of fibulin-3 causes early aging and herniation, but not macular degeneration in mice', Hum Mol Genet, 16: 3059-70.
[42]. Mimatsu, K., H. Kano, T. Oida, A. Kawasaki, N. Fukino, K. Kida, Y. Kuboi, and S. Amano. 2014. 'Gastric Cancer Arising from an Upside-Down Stomach through a Paraesophageal Hiatal Hernia', Case Rep Gastroenterol, 8: 107-14.
[43]. Mizuno, H., H. Nagai, S. Maeda, H. Miyake, Y. Yoshioka, and N. Yuasa. 2019. 'Incarcerated sigmoid colon cancer in an inguinal hernia sac associated with an abdominal wall abscess: a case report', Surg Case Rep, 5: 189.
[44]. Morrison, A. S. 1976. 'Cryptorchidism, hernia, and cancer of the testis', J Natl Cancer Inst, 56: 731-3.
[45]. Ondrusova, M., and D. Ondrus. 2009. 'Epidemiological features of testicular cancer in the Slovak Republic--retrospective study', Klin Onkol, 22: 52-7.
[46]. Pottern, L. M., L. M. Brown, R. N. Hoover, N. Javadpour, K. J. O'Connell, R. E. Stutzman, and W. A. Blattner. 1985. 'Testicular cancer risk among young men: role of cryptorchidism and inguinal hernia', J Natl Cancer Inst, 74: 377-81.
[47]. Primatesta, P., and M. J. Goldacre. 1996. 'Inguinal hernia repair: incidence of elective and emergency surgery, readmission and mortality', Int J Epidemiol, 25: 835-9.
[48]. Qu, C. Y., Y. Zheng, M. Zhou, Y. Zhang, F. Shen, J. Cao, and L. M. Xu. 2015. 'Value of bevacizumab in treatment of colorectal cancer: A meta-analysis', World J Gastroenterol, 21: 5072-80.
[49]. Ramjist, J. K., F. Dossa, T. A. Stukel, D. R. Urbach, L. Fu, and N. N. Baxter. 2019. 'Reoperation for inguinal hernia recurrence in Ontario: a population-based study', Hernia, 23: 647-54.
[50]. Rao S S, Singh P, Gupta D, and Narang R. 2016. 'Clinicoepidemiologic profile of inguinal hernia in rural medical college in central India', J Mahatma Gandhi Inst Med Sci, 21.
[51]. Rong, Y., L. Cheng, H. Ning, J. Zou, Y. Zhang, F. Xu, L. Liu, Z. Chang, and X. Y. Fu. 2006. 'Wilms' tumor 1 and signal transducers and activators of transcription 3 synergistically promote cell proliferation: a possible mechanism in sporadic Wilms' tumor', Cancer Res, 66: 8049-57.
[52]. Rovito, M. J., S. Taylor, R. Lockwood, W. B. Adams, and M. Craycraft. 2020. 'Testicular Cancer Incidence and Mortality Within Rural and Urban Regions', J Adolesc Young Adult Oncol, 9: 202-07.
[53]. Salemans, P. B., G. F. Vles, S. A. Fransen, and R. M. Smeenk. 2013. 'Sigmoid carcinoma in an inguinal hernia: a blessing in disguise?', Case Rep Surg, 2013: 314394.
[54]. Schmidt, L., S. Oberg, K. Andresen, and J. Rosenberg. 2018. 'Recurrence Rates After Repair of Inguinal Hernia in Women: A Systematic Review', JAMA Surg, 153: 1135-42.
[55]. Shapira, S. N., H. W. Lim, S. Rajakumari, A. P. Sakers, J. Ishibashi, M. J. Harms, K. J. Won, and P. Seale. 2017. 'EBF2 transcriptionally regulates brown adipogenesis via the histone reader DPF3 and the BAF chromatin remodeling complex', Genes Dev, 31: 660-73.
[56]. Sung, H., J. Ferlay, R. L. Siegel, M. Laversanne, I. Soerjomataram, A. Jemal, and F. Bray. 2021. 'Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries', CA Cancer J Clin, 71: 209-49.
[57]. Swerdlow, A. J., S. R. Huttly, and P. G. Smith. 1987. 'Testicular cancer and antecedent diseases', Br J Cancer, 55: 97-103.
[58]. Szklarczyk, D., A. L. Gable, D. Lyon, A. Junge, S. Wyder, J. Huerta-Cepas, M. Simonovic, N. T. Doncheva, J. H. Morris, P. Bork, L. J. Jensen, and C. V. Mering. 2019. 'STRING v11: protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets', Nucleic Acids Res, 47: D607-D13.
[59]. Terezis NL., Davis WC., and Jackson FC. 1963. 'Carcinoma of the colon associated with Inguinal Hernia', The New England Journal of Medicine, 268: 774-76.
[60]. Uhlen, M., L. Fagerberg, B. M. Hallstrom, C. Lindskog, P. Oksvold, A. Mardinoglu, A. Sivertsson, C. Kampf, E. Sjostedt, A. Asplund, I. Olsson, K. Edlund, E. Lundberg, S. Navani, C. A. Szigyarto, J. Odeberg, D. Djureinovic, J. O. Takanen, S. Hober, T. Alm, P. H. Edqvist, H. Berling, H. Tegel, J. Mulder, J. Rockberg, P. Nilsson, J. M. Schwenk, M. Hamsten, K. von Feilitzen, M. Forsberg, L. Persson, F. Johansson, M. Zwahlen, G. von Heijne, J. Nielsen, and F. Ponten. 2015. 'Proteomics. Tissue-based map of the human proteome', Science, 347: 1260419.
[61]. Venclauskas, L., M. Jokubauskas, J. Zilinskas, K. Zviniene, and M. Kiudelis. 2017. 'Long-term follow-up results of umbilical hernia repair', Wideochir Inne Tech Maloinwazyjne, 12: 350-56.
[62]. Venook, A. P., D. Niedzwiecki, H. J. Lenz, F. Innocenti, B. Fruth, J. A. Meyerhardt, D. Schrag, C. Greene, B. H. O'Neil, J. N. Atkins, S. Berry, B. N. Polite, E. M. O'Reilly, R. M. Goldberg, H. S. Hochster, R. L. Schilsky, M. M. Bertagnolli, A. B. El-Khoueiry, P. Watson, A. B. Benson, 3rd, D. L. Mulkerin, R. J. Mayer, and C. Blanke. 2017. 'Effect of First-Line Chemotherapy Combined With Cetuximab or Bevacizumab on Overall Survival in Patients With KRAS Wild-Type Advanced or Metastatic Colorectal Cancer: A Randomized Clinical Trial', JAMA, 317: 2392-401.
[63]. Xiao, W. H., X. L. Qu, X. M. Li, Y. L. Sun, H. X. Zhao, S. Wang, and X. Zhou. 2015. 'Identification of commonly dysregulated genes in colorectal cancer by integrating analysis of RNA-Seq data and qRT-PCR validation', Cancer Gene Ther, 22: 278-84.
[64]. Zahnd, W. E., M. M. Davis, J. S. Rotter, R. C. Vanderpool, C. K. Perry, J. Shannon, L. K. Ko, S. B. Wheeler, C. L. Odahowski, P. E. Farris, and J. M. Eberth. 2019. 'Rural-urban differences in financial burden among cancer survivors: an analysis of a nationally representative survey', Support Care Cancer, 27: 4779-86.
[65]. Zahnd, W. E., A. S. James, W. D. Jenkins, S. R. Izadi, A. J. Fogleman, D. E. Steward, G. A. Colditz, and L. Brard. 2018. 'Rural-Urban Differences in Cancer Incidence and Trends in the United States', Cancer Epidemiol Biomarkers Prev, 27: 1265-74.
[66]. Zhang, H., Z. Huang, X. Zou, and T. Liu. 2016. 'Bevacizumab and wound-healing complications: a systematic review and meta-analysis of randomized controlled trials', Oncotarget, 7: 82473-81.
[67]. Zhou, Y. H., Y. Hu, L. Yu, C. Ke, Co, H. Hsu, Z. Li, A. T. Di Donato, A. Chaturbedi, J. W. Hwang, E. R. Siegel, and M. E. Linskey. 2016. 'Weaponizing human EGF-containing fibulin-like extracellular matrix protein 1 (EFEMP1) for 21(st) century cancer therapeutics', Oncoscience, 3: 208-19.
[2]. Antoniou, G. A., G. S. Georgiadis, S. A. Antoniou, F. A. Granderath, A. D. Giannoukas, and M. K. Lazarides. 2011. 'Abdominal aortic aneurysm and abdominal wall hernia as manifestations of a connective tissue disorder', J Vasc Surg, 54: 1175-81.
[3]. Antoniou, G. A., I. K. Tentes, S. A. Antoniou, C. Simopoulos, and M. K. Lazarides. 2011. 'Matrix metalloproteinase imbalance in inguinal hernia formation', J Invest Surg, 24: 145-50.
[4]. Baudry, D., M. Faussillon, M. O. Cabanis, M. Rigolet, J. M. Zucker, C. Patte, S. Sarnacki, L. Boccon-Gibod, C. Junien, and C. Jeanpierre. 2002. 'Changes in WT1 splicing are associated with a specific gene expression profile in Wilms' tumour', Oncogene, 21: 5566-73.
[5]. Bendavid, R. 2004. 'The unified theory of hernia formation', Hernia, 8: 171-6.
[6]. Birolini, C., E.M. Utiyama, A.J. Rodrigues, and D. Birolini. 1998. 'The association of inguinal hernias and colon cancer. A technical strategy based upon three patients.', Hernia, 2: 139-43.
[7]. Bollu J, Sunkara VR , and Vankadara S. 2020. 'Study of Demographic, Risk factors and Evidence based Hernia repair and its
[8]. Management in Adults in Tertiary care Hospital ', International Journal of Allied Medical Sciences and Clinical Research, 8: 781-88.
[9]. Bray, F., M. Laversanne, E. Weiderpass, and I. Soerjomataram. 2021. 'The ever-increasing importance of cancer as a leading cause of premature death worldwide', Cancer, 127: 3029-30.
[10]. Brocker, C. N., V. Vasiliou, and D. W. Nebert. 2009. 'Evolutionary divergence and functions of the ADAM and ADAMTS gene families', Hum Genomics, 4: 43-55.
[11]. Carmona, R., A. Canete, E. Cano, L. Ariza, A. Rojas, and R. Munoz-Chapuli. 2016. 'Conditional deletion of WT1 in the septum transversum mesenchyme causes congenital diaphragmatic hernia in mice', Elife, 5.
[12]. Casanova, A. B., E. N. Trindade, and M. R. Trindade. 2009. 'Collagen in the transversalis fascia of patients with indirect inguinal hernia: a case-control study', Am J Surg, 198: 1-5.
[13]. Coldman, A. J., J. M. Elwood, and R. P. Gallagher. 1982. 'Sports activities and risk of testicular cancer', Br J Cancer, 46: 749-56.
[14]. Collot, T., J. D. Fumet, Q. Klopfenstein, J. Vincent, L. Bengrine, and F. Ghiringhelli. 2018. 'Bevacizumab-based Chemotherapy for Poorly-differentiated Neuroendocrine Tumors', Anticancer Res, 38: 5963-68.
[15]. Cook, M. B., O. Akre, D. Forman, M. P. Madigan, L. Richiardi, and K. A. McGlynn. 2010. 'A systematic review and meta-analysis of perinatal variables in relation to the risk of testicular cancer--experiences of the son', Int J Epidemiol, 39: 1605-18.
[16]. Davis, WC., and FC. Jackson. 1968. 'Inguinal Hernia and Colon Carcinoma', CA: A Cancer Journal for Clinicians, 18: 143-45.
[17]. Dingemann, J., T. Doi, E. Ruttenstock, and P. Puri. 2011. 'Expression of the Wilm's tumor gene WT1 during diaphragmatic development in the nitrofen model for congenital diaphragmatic hernia', Pediatr Surg Int, 27: 159-63.
[18]. Eriksen, M., and O. Bulut. 2014. 'Chemotherapy-induced enterocutaneous fistula after perineal hernia repair using a biological mesh: a case report', Int Med Case Rep J, 7: 11-3.
[19]. Eveno, C., G. Passot, D. Goere, P. Soyer, E. Gayat, O. Glehen, D. Elias, and M. Pocard. 2014. 'Bevacizumab doubles the early postoperative complication rate after cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (HIPEC) for peritoneal carcinomatosis of colorectal origin', Ann Surg Oncol, 21: 1792-800.
[20]. Gallagher, R. P., S. Huchcroft, N. Phillips, G. B. Hill, A. J. Coldman, C. Coppin, and T. Lee. 1995. 'Physical activity, medical history, and risk of testicular cancer (Alberta and British Columbia, Canada)', Cancer Causes Control, 6: 398-406.
[21]. Giakoustidis, A., D. Morrison, K. Neofytou, D. Giakoustidis, and S. Mudan. 2014. 'Emergency open incarcerated hernia repair with a biological mesh in a patient with colorectal liver metastasis receiving chemotherapy and bevacizumab uncomplicated wound healing', Case Rep Emerg Med, 2014: 848030.
[22]. Glanze WD, Anderson KN, Anderson LE, Urdang L, and Swallow HH. 1986. 'Mosby Medical and Nursing Dictionary', The CV Mosby Company, Saint Louis. 2nd ED: 528.
[23]. Goldman, M. J., B. Craft, M. Hastie, K. Repecka, F. McDade, A. Kamath, A. Banerjee, Y. Luo, D. Rogers, A. N. Brooks, J. Zhu, and D. Haussler. 2020. 'Visualizing and interpreting cancer genomics data via the Xena platform', Nat Biotechnol, 38: 675-78.
[24]. Group, United Kingdom Testicular Cancer Study. 1994. 'Aetiology of testicular cancer: association with congenital abnormalities, age at puberty, infertility, and exercise. United Kingdom Testicular Cancer Study Group', BMJ, 308: 1393-9.
[25]. Hajibandeh, S., S. Hajibandeh, A. Sreh, A. Khan, D. Subar, and L. Jones. 2017. 'Laparoscopic versus open umbilical or paraumbilical hernia repair: a systematic review and meta-analysis', Hernia, 21: 905-16.
[26]. Hapani, S., D. Chu, and S. Wu. 2009. 'Risk of gastrointestinal perforation in patients with cancer treated with bevacizumab: a meta-analysis', Lancet Oncol, 10: 559-68.
[27]. HerniaSurge, Group. 2018. 'International guidelines for groin hernia management', Hernia, 22: 1-165.
[28]. Honecker, F., J. Aparicio, D. Berney, J. Beyer, C. Bokemeyer, R. Cathomas, N. Clarke, G. Cohn-Cedermark, G. Daugaard, K. P. Dieckmann, K. Fizazi, S. Fossa, J. R. Germa-Lluch, P. Giannatempo, J. A. Gietema, S. Gillessen, H. S. Haugnes, A. Heidenreich, K. Hemminki, R. Huddart, M. A. S. Jewett, F. Joly, J. Lauritsen, A. Lorch, A. Necchi, N. Nicolai, C. Oing, J. Oldenburg, D. Ondrus, A. Papachristofilou, T. Powles, A. Sohaib, O. Stahl, T. Tandstad, G. Toner, and A. Horwich. 2018. 'ESMO Consensus Conference on testicular germ cell cancer: diagnosis, treatment and follow-up', Ann Oncol, 29: 1658-86.
[29]. Jenkins, J. T., and P. J. O'Dwyer. 2008. 'Inguinal hernias', BMJ, 336: 269-72.
[30]. Jha S, and Pankaj D. 2020. 'A study to assess the prevalence and risk factors of
[31]. Inguinal hernia', International Journal of Surgery Science, 4: 330-32.
[32]. Jorgenson, E., N. Makki, L. Shen, D. C. Chen, C. Tian, W. L. Eckalbar, D. Hinds, N. Ahituv, and A. Avins. 2015. 'A genome-wide association study identifies four novel susceptibility loci underlying inguinal hernia', Nat Commun, 6: 10130.
[33]. Kingsnorth, A., and K. LeBlanc. 2003. 'Hernias: inguinal and incisional', Lancet, 362: 1561-71.
[34]. Klenotic, P. A., F. L. Munier, L. Y. Marmorstein, and B. Anand-Apte. 2004. 'Tissue inhibitor of metalloproteinases-3 (TIMP-3) is a binding partner of epithelial growth factor-containing fibulin-like extracellular matrix protein 1 (EFEMP1). Implications for macular degenerations', J Biol Chem, 279: 30469-73.
[35]. Kulacoglu, H., and F. Kockerling. 2019. 'Hernia and Cancer: The Points Where the Roads Intersect', Front Surg, 6: 19.
[36]. Laschke, M. W., J. M. Haufel, J. Roller, H. Schorr, and M. D. Menger. 2009. 'Rapamycin, but not cyclosporine A, inhibits vascularization and incorporation of implanted surgical meshes', Transpl Int, 22: 654-62.
[37]. Law, B. K. 2005. 'Rapamycin: an anti-cancer immunosuppressant?', Crit Rev Oncol Hematol, 56: 47-60.
[38]. Li, X., Y. Deng, W. Tang, Q. Sun, Y. Chen, C. Yang, B. Yan, Y. Wang, J. Wang, S. Wang, F. Yang, Y. Ding, G. Zhao, and G. Cao. 2018. 'Urban-Rural Disparity in Cancer Incidence, Mortality, and Survivals in Shanghai, China, During 2002 and 2015', Front Oncol, 8: 579.
[39]. Ma, X., Y. Liu, Q. Wang, Y. Chen, M. Liu, X. Li, R. Xiang, Y. Wei, Y. Duan, and J. Han. 2015. 'Tamoxifen induces the development of hernia in mice by activating MMP-2 and MMP-13 expression', Biochim Biophys Acta, 1852: 1038-48.
[40]. Mai, P. L., M. Friedlander, K. Tucker, K. A. Phillips, D. Hogg, M. A. Jewett, R. Lohynska, G. Daugaard, S. Richard, C. Bonaiti-Pellie, A. Heidenreich, P. Albers, I. Bodrogi, L. Geczi, E. Olah, P. A. Daly, P. Guilford, S. D. Fossa, K. Heimdal, L. Liubchenko, S. A. Tjulandin, H. Stoll, W. Weber, D. F. Easton, zD. Dudakia, R. Huddart, M. R. Stratton, L. Einhorn, L. Korde, K. L. Nathanson, D. T. Bishop, E. A. Rapley, and M. H. Greene. 2010. 'The International Testicular Cancer Linkage Consortium: a clinicopathologic descriptive analysis of 461 familial malignant testicular germ cell tumor kindred', Urol Oncol, 28: 492-9.
[41]. McLaughlin, P. J., B. Bakall, J. Choi, Z. Liu, T. Sasaki, E. C. Davis, A. D. Marmorstein, and L. Y. Marmorstein. 2007. 'Lack of fibulin-3 causes early aging and herniation, but not macular degeneration in mice', Hum Mol Genet, 16: 3059-70.
[42]. Mimatsu, K., H. Kano, T. Oida, A. Kawasaki, N. Fukino, K. Kida, Y. Kuboi, and S. Amano. 2014. 'Gastric Cancer Arising from an Upside-Down Stomach through a Paraesophageal Hiatal Hernia', Case Rep Gastroenterol, 8: 107-14.
[43]. Mizuno, H., H. Nagai, S. Maeda, H. Miyake, Y. Yoshioka, and N. Yuasa. 2019. 'Incarcerated sigmoid colon cancer in an inguinal hernia sac associated with an abdominal wall abscess: a case report', Surg Case Rep, 5: 189.
[44]. Morrison, A. S. 1976. 'Cryptorchidism, hernia, and cancer of the testis', J Natl Cancer Inst, 56: 731-3.
[45]. Ondrusova, M., and D. Ondrus. 2009. 'Epidemiological features of testicular cancer in the Slovak Republic--retrospective study', Klin Onkol, 22: 52-7.
[46]. Pottern, L. M., L. M. Brown, R. N. Hoover, N. Javadpour, K. J. O'Connell, R. E. Stutzman, and W. A. Blattner. 1985. 'Testicular cancer risk among young men: role of cryptorchidism and inguinal hernia', J Natl Cancer Inst, 74: 377-81.
[47]. Primatesta, P., and M. J. Goldacre. 1996. 'Inguinal hernia repair: incidence of elective and emergency surgery, readmission and mortality', Int J Epidemiol, 25: 835-9.
[48]. Qu, C. Y., Y. Zheng, M. Zhou, Y. Zhang, F. Shen, J. Cao, and L. M. Xu. 2015. 'Value of bevacizumab in treatment of colorectal cancer: A meta-analysis', World J Gastroenterol, 21: 5072-80.
[49]. Ramjist, J. K., F. Dossa, T. A. Stukel, D. R. Urbach, L. Fu, and N. N. Baxter. 2019. 'Reoperation for inguinal hernia recurrence in Ontario: a population-based study', Hernia, 23: 647-54.
[50]. Rao S S, Singh P, Gupta D, and Narang R. 2016. 'Clinicoepidemiologic profile of inguinal hernia in rural medical college in central India', J Mahatma Gandhi Inst Med Sci, 21.
[51]. Rong, Y., L. Cheng, H. Ning, J. Zou, Y. Zhang, F. Xu, L. Liu, Z. Chang, and X. Y. Fu. 2006. 'Wilms' tumor 1 and signal transducers and activators of transcription 3 synergistically promote cell proliferation: a possible mechanism in sporadic Wilms' tumor', Cancer Res, 66: 8049-57.
[52]. Rovito, M. J., S. Taylor, R. Lockwood, W. B. Adams, and M. Craycraft. 2020. 'Testicular Cancer Incidence and Mortality Within Rural and Urban Regions', J Adolesc Young Adult Oncol, 9: 202-07.
[53]. Salemans, P. B., G. F. Vles, S. A. Fransen, and R. M. Smeenk. 2013. 'Sigmoid carcinoma in an inguinal hernia: a blessing in disguise?', Case Rep Surg, 2013: 314394.
[54]. Schmidt, L., S. Oberg, K. Andresen, and J. Rosenberg. 2018. 'Recurrence Rates After Repair of Inguinal Hernia in Women: A Systematic Review', JAMA Surg, 153: 1135-42.
[55]. Shapira, S. N., H. W. Lim, S. Rajakumari, A. P. Sakers, J. Ishibashi, M. J. Harms, K. J. Won, and P. Seale. 2017. 'EBF2 transcriptionally regulates brown adipogenesis via the histone reader DPF3 and the BAF chromatin remodeling complex', Genes Dev, 31: 660-73.
[56]. Sung, H., J. Ferlay, R. L. Siegel, M. Laversanne, I. Soerjomataram, A. Jemal, and F. Bray. 2021. 'Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries', CA Cancer J Clin, 71: 209-49.
[57]. Swerdlow, A. J., S. R. Huttly, and P. G. Smith. 1987. 'Testicular cancer and antecedent diseases', Br J Cancer, 55: 97-103.
[58]. Szklarczyk, D., A. L. Gable, D. Lyon, A. Junge, S. Wyder, J. Huerta-Cepas, M. Simonovic, N. T. Doncheva, J. H. Morris, P. Bork, L. J. Jensen, and C. V. Mering. 2019. 'STRING v11: protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets', Nucleic Acids Res, 47: D607-D13.
[59]. Terezis NL., Davis WC., and Jackson FC. 1963. 'Carcinoma of the colon associated with Inguinal Hernia', The New England Journal of Medicine, 268: 774-76.
[60]. Uhlen, M., L. Fagerberg, B. M. Hallstrom, C. Lindskog, P. Oksvold, A. Mardinoglu, A. Sivertsson, C. Kampf, E. Sjostedt, A. Asplund, I. Olsson, K. Edlund, E. Lundberg, S. Navani, C. A. Szigyarto, J. Odeberg, D. Djureinovic, J. O. Takanen, S. Hober, T. Alm, P. H. Edqvist, H. Berling, H. Tegel, J. Mulder, J. Rockberg, P. Nilsson, J. M. Schwenk, M. Hamsten, K. von Feilitzen, M. Forsberg, L. Persson, F. Johansson, M. Zwahlen, G. von Heijne, J. Nielsen, and F. Ponten. 2015. 'Proteomics. Tissue-based map of the human proteome', Science, 347: 1260419.
[61]. Venclauskas, L., M. Jokubauskas, J. Zilinskas, K. Zviniene, and M. Kiudelis. 2017. 'Long-term follow-up results of umbilical hernia repair', Wideochir Inne Tech Maloinwazyjne, 12: 350-56.
[62]. Venook, A. P., D. Niedzwiecki, H. J. Lenz, F. Innocenti, B. Fruth, J. A. Meyerhardt, D. Schrag, C. Greene, B. H. O'Neil, J. N. Atkins, S. Berry, B. N. Polite, E. M. O'Reilly, R. M. Goldberg, H. S. Hochster, R. L. Schilsky, M. M. Bertagnolli, A. B. El-Khoueiry, P. Watson, A. B. Benson, 3rd, D. L. Mulkerin, R. J. Mayer, and C. Blanke. 2017. 'Effect of First-Line Chemotherapy Combined With Cetuximab or Bevacizumab on Overall Survival in Patients With KRAS Wild-Type Advanced or Metastatic Colorectal Cancer: A Randomized Clinical Trial', JAMA, 317: 2392-401.
[63]. Xiao, W. H., X. L. Qu, X. M. Li, Y. L. Sun, H. X. Zhao, S. Wang, and X. Zhou. 2015. 'Identification of commonly dysregulated genes in colorectal cancer by integrating analysis of RNA-Seq data and qRT-PCR validation', Cancer Gene Ther, 22: 278-84.
[64]. Zahnd, W. E., M. M. Davis, J. S. Rotter, R. C. Vanderpool, C. K. Perry, J. Shannon, L. K. Ko, S. B. Wheeler, C. L. Odahowski, P. E. Farris, and J. M. Eberth. 2019. 'Rural-urban differences in financial burden among cancer survivors: an analysis of a nationally representative survey', Support Care Cancer, 27: 4779-86.
[65]. Zahnd, W. E., A. S. James, W. D. Jenkins, S. R. Izadi, A. J. Fogleman, D. E. Steward, G. A. Colditz, and L. Brard. 2018. 'Rural-Urban Differences in Cancer Incidence and Trends in the United States', Cancer Epidemiol Biomarkers Prev, 27: 1265-74.
[66]. Zhang, H., Z. Huang, X. Zou, and T. Liu. 2016. 'Bevacizumab and wound-healing complications: a systematic review and meta-analysis of randomized controlled trials', Oncotarget, 7: 82473-81.
[67]. Zhou, Y. H., Y. Hu, L. Yu, C. Ke, Co, H. Hsu, Z. Li, A. T. Di Donato, A. Chaturbedi, J. W. Hwang, E. R. Siegel, and M. E. Linskey. 2016. 'Weaponizing human EGF-containing fibulin-like extracellular matrix protein 1 (EFEMP1) for 21(st) century cancer therapeutics', Oncoscience, 3: 208-19.