The Effectiveness of Garlic Extract Ointment on the Healing of Perineal Wounds in Mice
Corresponding Author(s) : Syifa Sofia Wibowo
syifasofia1998@gmail.com
International Journal of Allied Medical Sciences and Clinical Research,
Vol. 9 No. 3 (2021): 2021 Volume - 9 Issue - 3
Abstract
Perineal wound is one of the most frequently infected areas during the puerperium and is the second most common cause of primary postpartum hemorrhage. The allicin compound in garlic acts as an anti-platelet cell aggregation, anti-inflammatory and fibrinolysis booster that can accelerate the wound healing process. The aim of the study was to analyzing the effectiveness of 30% garlic extract ointment compared to 10% povidone iodine on perineal wound healing in rats. The research design is true experiment with the post test method with control group on 12 wistar rats. The wound was given as long as ±0.5 cm deep to the dermis in the perineal area of ??the rat. The control group was given 10% povidone iodine ointment and the intervention group was given 30% garlic extract ointment. The measuring instrument in this study used the REEDA scale and histological examination. Result of research showed that wound healing in the intervention group was faster than the control group (6 days versus 7 days). The results of independent t-test on the REEDA scale and histology examination showed sig. 0.000 and 0.0017 which means that there is a difference between the two groups based on the two measuring instruments. The use of 30% garlic extract ointment is more effective for healing perineal wounds.
Keywords
Garlic Extract
Perineal Wound
Postpartum
1.
Syifa Sofia Wibowo, Choiroel Anwar, Masrifan Djamil, Runjati. The Effectiveness of Garlic Extract Ointment on the Healing of Perineal Wounds in Mice. Int. J. of Allied Med. Sci. and Clin. Res. [Internet]. 2021 Sep. 1 [cited 2025 Nov. 6];9(3):514-9. Available from: https://ijamscr.com/ijamscr/article/view/1061
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References
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[14]. Ashfaq et al. (2021) ‘Therapeutic Activities Of Garlic Constituent Phytochemicals’, Biological And Clinical Sciences Research Journal, e007, pp. 1–9. doi: 10.47264/bcsrj0201007.
[15]. Dewi, M. M., Djamil, M. and Anwar, M. C. (2019) ‘Education M Health Android-Based Smartphone Media Application “Mama ASIX” For Third Trimester Pregnant Women As Preparation For Exclusive Breastfeeding’, 4, pp. 98–109.
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[17]. Apriyani, D., Djamil, M. and Kumorowulan, S. (2020) ‘Effectiveness Of Chayote Extract On Lowering Blood Pressure Of Post Partum Hypertension’, STRADA Jurnal Ilmiah Kesehatan, 9(2), pp. 801–812. doi: 10.30994/sjik.v9i2.370.
[18]. Babadi, N. A. et al. (2018) ‘Investigating The Effect Of Sesame Ointment On Wound Healing Of Episiotomy’, International Journal O Ayurvedic Medicine, 9(3), pp. 182–184.
[19]. Moulia, M. N. et al. (2018) ‘Antimikroba Ekstrak Bawang Putih’, Jurnal Pangan, 27(1), pp. 55–66.
References
[1]. Karjatin, A. (2016) Keperawatan Maternitas. Cetakan Pe, Kementerian Kesehatan Republik Indonesia. Cetakan Pe. Edited by A. Suryono. Jakarta: Pusat Pendidikan Sumber Daya Manusia Kesehatan.
[2]. Purwaningsih, A., Rahayu, H. and Wijayanti, K. (2015) ‘Effectiveness of warm compress and cold compress to reduce laceration perineum pain on primiparous at Candimulyo Magelang 2015’, International Journal of Research in Medical Sciences, 3(1), pp. S24–S29. doi: 10.18203/2320-6012.ijrms20151516.
[3]. Alvarenga, M. B. et al. (2015) ‘Episiotomy healing assessment: Redness, oedema, ecchymosis, discharge, approximation (REEDA) scale reliability’, Revista Latino-Americana de Enfermagem, 23(1), pp. 162–168. doi: 10.1590/0104-1169.3633.2538.
[4]. Kartikaningtyas, A. T., Prayitno and Lastianny, S. P. (2015) ‘Pengaruh Aplikasi Gel Ekstrak Kulit Citrus Sinensis Terhadap Epitelisasi Pada Penyembuhan Luka Gingiva Tikus Sprague Dawley’, Majalah Kedokteran Gigi Indonesia, 1(1), pp. 86–93. doi: 10.22146/majkedgiind.9012.
[5]. Zukhri, S. and Hidayati, N. (2017) ‘Aktivitas Antimikroba Ekstrak Etanol Pelepah Pisang Raja (Musa x paradisiaca L .) pada Bakteri Staphylococcus Aureus’, Gaster, XV(2), pp. 216–231.
[6]. Susilawati, E. and Ilda, W. R. (2019) ‘Efektifitas Kompres Hangat Dan Kompres Dingin Terhadap Intensitas Nyeri Luka Perineum Pada Ibu Post Partum Di Bpm Siti Julaeha Pekanbaru’, Journal Of Midwifery Science, 3(1), pp. 7–14.
[7]. Untari, I. (2010) ‘Bawang Putih Sebagai Obat Paling Mujarab Bagi Kesehatan’, Gaster, 7(1), pp. 547–554. Available at: https://www.jurnal.stikes-aisyiyah.ac.id/index.php/gaster/article/view/59.
[8]. Hernawan, U. E. and Setyawan, A. D. (2014) ‘Senyawa Organosulfur Bawang Putih ( Allium sativum L .) dan Aktivitas Biologinya Aktivitas Biologinya’, Biofarmasi Jurusan Biologi FMIPA UNS, 1(August 2003), pp. 64–76.
[9]. Prasonto, D., Riyanti, E. and Gartika, M. (2017) ‘Uji Aktivitas Antioksidan Ekstrak Bawang Putih (Allium sativum)’, ODONTO?: Dental Journal, 4(2), p. 122. doi: 10.30659/odj.4.2.122-128.
[10]. Wardiyah, S. (2015) ‘Perbandingan Sifat Fisik Sediaan Krim, Gel, Dan Salep Yang Mengandung Etil P- Metoksisinamat Dari Ekstrak Rimpang Kencur (Kaempferia galanga Linn.)’, Skripsi.
[11]. Utami, P. P. (2018) ‘Salep Ekstrak Gedebog Pisang (Musa Balbisiana) Sebagai Alternatif Penyembuhan Luka Perineum (Uji Laboratorium Pada Tikus)’. PRODI MAGISTER TERAPAN KEBIDANAN. Available at: http://repository.poltekkes-smg.ac.id/index.php?p=show_detail&id=17501&keywords= (Accessed: 24 June 2020).
[12]. Annachira Kushalappa, J. et al. (2015) ‘International Journal of Biomedical Research’, International Journal of Biomedical Research, 6(09), p. 6. doi: 10.7439/ijbr.
[13]. Ejaz, S. et al. (2009) ‘Effect Of Aged Garlic Extract On Wound Healing?: A New Frontier In Wound Management’, Drug and Chemical Toxicology, 32(3), pp. 191–203. doi: 10.1080/01480540902862236.
[14]. Ashfaq et al. (2021) ‘Therapeutic Activities Of Garlic Constituent Phytochemicals’, Biological And Clinical Sciences Research Journal, e007, pp. 1–9. doi: 10.47264/bcsrj0201007.
[15]. Dewi, M. M., Djamil, M. and Anwar, M. C. (2019) ‘Education M Health Android-Based Smartphone Media Application “Mama ASIX” For Third Trimester Pregnant Women As Preparation For Exclusive Breastfeeding’, 4, pp. 98–109.
[16]. Mescher, A. L. (2016) Junqueira’s Basic Histology Text And Atlas. 14th editi, Mc Graw Hill Education. 14th editi. United States. doi: 10.5005/jp/books/12791_18.
[17]. Apriyani, D., Djamil, M. and Kumorowulan, S. (2020) ‘Effectiveness Of Chayote Extract On Lowering Blood Pressure Of Post Partum Hypertension’, STRADA Jurnal Ilmiah Kesehatan, 9(2), pp. 801–812. doi: 10.30994/sjik.v9i2.370.
[18]. Babadi, N. A. et al. (2018) ‘Investigating The Effect Of Sesame Ointment On Wound Healing Of Episiotomy’, International Journal O Ayurvedic Medicine, 9(3), pp. 182–184.
[19]. Moulia, M. N. et al. (2018) ‘Antimikroba Ekstrak Bawang Putih’, Jurnal Pangan, 27(1), pp. 55–66.
[2]. Purwaningsih, A., Rahayu, H. and Wijayanti, K. (2015) ‘Effectiveness of warm compress and cold compress to reduce laceration perineum pain on primiparous at Candimulyo Magelang 2015’, International Journal of Research in Medical Sciences, 3(1), pp. S24–S29. doi: 10.18203/2320-6012.ijrms20151516.
[3]. Alvarenga, M. B. et al. (2015) ‘Episiotomy healing assessment: Redness, oedema, ecchymosis, discharge, approximation (REEDA) scale reliability’, Revista Latino-Americana de Enfermagem, 23(1), pp. 162–168. doi: 10.1590/0104-1169.3633.2538.
[4]. Kartikaningtyas, A. T., Prayitno and Lastianny, S. P. (2015) ‘Pengaruh Aplikasi Gel Ekstrak Kulit Citrus Sinensis Terhadap Epitelisasi Pada Penyembuhan Luka Gingiva Tikus Sprague Dawley’, Majalah Kedokteran Gigi Indonesia, 1(1), pp. 86–93. doi: 10.22146/majkedgiind.9012.
[5]. Zukhri, S. and Hidayati, N. (2017) ‘Aktivitas Antimikroba Ekstrak Etanol Pelepah Pisang Raja (Musa x paradisiaca L .) pada Bakteri Staphylococcus Aureus’, Gaster, XV(2), pp. 216–231.
[6]. Susilawati, E. and Ilda, W. R. (2019) ‘Efektifitas Kompres Hangat Dan Kompres Dingin Terhadap Intensitas Nyeri Luka Perineum Pada Ibu Post Partum Di Bpm Siti Julaeha Pekanbaru’, Journal Of Midwifery Science, 3(1), pp. 7–14.
[7]. Untari, I. (2010) ‘Bawang Putih Sebagai Obat Paling Mujarab Bagi Kesehatan’, Gaster, 7(1), pp. 547–554. Available at: https://www.jurnal.stikes-aisyiyah.ac.id/index.php/gaster/article/view/59.
[8]. Hernawan, U. E. and Setyawan, A. D. (2014) ‘Senyawa Organosulfur Bawang Putih ( Allium sativum L .) dan Aktivitas Biologinya Aktivitas Biologinya’, Biofarmasi Jurusan Biologi FMIPA UNS, 1(August 2003), pp. 64–76.
[9]. Prasonto, D., Riyanti, E. and Gartika, M. (2017) ‘Uji Aktivitas Antioksidan Ekstrak Bawang Putih (Allium sativum)’, ODONTO?: Dental Journal, 4(2), p. 122. doi: 10.30659/odj.4.2.122-128.
[10]. Wardiyah, S. (2015) ‘Perbandingan Sifat Fisik Sediaan Krim, Gel, Dan Salep Yang Mengandung Etil P- Metoksisinamat Dari Ekstrak Rimpang Kencur (Kaempferia galanga Linn.)’, Skripsi.
[11]. Utami, P. P. (2018) ‘Salep Ekstrak Gedebog Pisang (Musa Balbisiana) Sebagai Alternatif Penyembuhan Luka Perineum (Uji Laboratorium Pada Tikus)’. PRODI MAGISTER TERAPAN KEBIDANAN. Available at: http://repository.poltekkes-smg.ac.id/index.php?p=show_detail&id=17501&keywords= (Accessed: 24 June 2020).
[12]. Annachira Kushalappa, J. et al. (2015) ‘International Journal of Biomedical Research’, International Journal of Biomedical Research, 6(09), p. 6. doi: 10.7439/ijbr.
[13]. Ejaz, S. et al. (2009) ‘Effect Of Aged Garlic Extract On Wound Healing?: A New Frontier In Wound Management’, Drug and Chemical Toxicology, 32(3), pp. 191–203. doi: 10.1080/01480540902862236.
[14]. Ashfaq et al. (2021) ‘Therapeutic Activities Of Garlic Constituent Phytochemicals’, Biological And Clinical Sciences Research Journal, e007, pp. 1–9. doi: 10.47264/bcsrj0201007.
[15]. Dewi, M. M., Djamil, M. and Anwar, M. C. (2019) ‘Education M Health Android-Based Smartphone Media Application “Mama ASIX” For Third Trimester Pregnant Women As Preparation For Exclusive Breastfeeding’, 4, pp. 98–109.
[16]. Mescher, A. L. (2016) Junqueira’s Basic Histology Text And Atlas. 14th editi, Mc Graw Hill Education. 14th editi. United States. doi: 10.5005/jp/books/12791_18.
[17]. Apriyani, D., Djamil, M. and Kumorowulan, S. (2020) ‘Effectiveness Of Chayote Extract On Lowering Blood Pressure Of Post Partum Hypertension’, STRADA Jurnal Ilmiah Kesehatan, 9(2), pp. 801–812. doi: 10.30994/sjik.v9i2.370.
[18]. Babadi, N. A. et al. (2018) ‘Investigating The Effect Of Sesame Ointment On Wound Healing Of Episiotomy’, International Journal O Ayurvedic Medicine, 9(3), pp. 182–184.
[19]. Moulia, M. N. et al. (2018) ‘Antimikroba Ekstrak Bawang Putih’, Jurnal Pangan, 27(1), pp. 55–66.