@article{Nur Syahria_Suharyo Hadisaputro_Yuni Kusmiyati_2022, title={The Effect of Tahongai Leaf Extract (Kleinhovia Hospita Linn) on the Growth of Candida Albicans In Female Mice Vaginal Candidiasis}, volume={10}, url={https://ijamscr.com/ijamscr/article/view/1170}, DOI={10.61096/ijamscr.v10.iss2.2022.148-151}, abstractNote={Background Vaginal discharge is one of the problems that occur in women and about 80% occurs at the age of 15-45 years. This can trigger the development of fungi that cause vaginal discharge and the risk of vaginal candidiasis, namely candida albicans yeast infection. Tahongai leaf medicinal plants contain phenolic compounds (flavonoids, tannins, terpenoids, alkaloids) which show the ability to treat vaginal discharge caused by candida albicans by inhibiting ergosterol in cell membranes and affecting the function of enzymes so that they are antifungal. Purpose Analyze the effect of Tahongai (Kleinhovia hospital linn) leaf extract at a dose of 500mg/kg BW and 750mg/kg BW for 14 days on the growth of candida albicans in female mice vaginal candidiasis. Method True experimental study of female mice (Mus musculus) which consisted of 4 groups, namely the experimental group at a dose of 500mg/kg BW, the experimental group 750mg/kg BW, the positive control group (Ketoconazole) which was given 1 x 1 for 14 days, and the control negative group. Results Tahongai leaf extract (Kleinhovia hospita linn) dose of 750mg/kgBB once daily for 14 days affected suppressing the growth of candida albicans in female mice vaginal candidiasis with a decrease in the average number of colonies of 31 cfu/ml with a p-value of 0.010 <0.05, while the Tahongai leaf extract dose of 500mg/kg BW showed a decrease in the number of colonies but not significant (p-value 0.430). Conclusion Tahongai leaf extract (Kleinhovia hospita linn) at a dose of 750mg/kgBW for 14 days affected suppressing the growth of candida albicans in female mice vaginal candidiasis. }, number={2}, journal={International Journal of Allied Medical Sciences and Clinical Research}, author={Nur Syahria and Suharyo Hadisaputro and Yuni Kusmiyati}, year={2022}, month={Apr.}, pages={148–151} }