The in vitro antioxidant activity of P. murex  reportedwas ifor DPPH activity and nitric oxide, hydrogen peroxide superoxide scavenging activityinvivo activity is using corbontetra chloride induced hepatotoxic model in rats at 70mg/kg body wt implying their important to human health. [14].

The ethyl acetate (EA) fraction was found to have high levels of phenolic content [(295.75±1.31) mg GAE/g]. This fraction exhibited higher total antioxidant capacity, higher percentage of DPPH radical scavenging activity [(135.11±2.95) µg/mL], nitric oxide [(200.57±4.51) µg/mL], hydrogen peroxide [(217.91±6.12) µg/mL], deoxyribose [(250.01±4.68) µg/mL] and highly reduced activity. Correlation coefficient (r²–0.914) was found to be significant between total phenolic content and total antioxidant activity. The results indicate that the ethyl acetate fractions are rich in phenolic ant oxidants with potent free radical scavenging activity implying their importance to human health [13].

The anti hyperlipidemic potential of the methanolic extract from the fruits of P. murex at dose level of 200 and 400 mg/kg, . in HFD rats. Biochemical studies determinedserum Low density lipoproteins, very low density lipoproteins, total cholesterol ,highdensity lipoproteins, and triglycerides levels were noted and compared with animals activities treated with standards atorvastatin. The methanolic extract of this plant produced significant increase in HDL (P < 0.05) levels at tested doses significant decrease in triglycerides (P<0.01), LDL (P <0.001), VLDL (P < 0.01), cholesterol (P < 0.001) [6].

Impact of ethanol extract of P. murex root (0.1%, 0.2%, 0.4% and 0.8%) were screened for its anti-feedent and insecticidal activities against third, fourth and fifth instar larvae of Spodopteralitura (S. litura) (Fab.) by leaf-dip method. The larval mortality more than 50 percent at higher concentration (0.8%) was observed in the ethanol root extract. Stage dependant LC₅₀ value was observed for S. litura (0.100%, 0.118% and 0.258% for third, fourth and fifth nymphal instars).  P. murex impact was stronger than the neem based biopesticidal of neem gold. Hence this plant can be explored as biopesticidal plant in the near future [7].

P. murex (Linn), useful in urinary diseases conditions is distributed in the coastal areas of south India. The work was to study the anti nephrolithiatic activity of various extracts of P. murex. Petroleum ether, chloroform, ethanol and aqueous extracts of the plant were prepared and evaluated for anti nephrolithiasis activity. rats were treated with the prepared extracts. This plant reported to significantly reducedt anti nephrolithiatic activity [8].

The ethanolic extract of fruits of P. murex was evaluated for nephroprotective activity in cisplatin induced renal damage in rats. Administration plant ethanolic extract at a dose of 200 mg/kg given by oral route was determined using creatinine and blood urea and change in body weight as indicators of kidney damage. Cystone is standard. This extract is significantly reduced the cisplatin induced nephrotoxicity. [9].

Peptic ulcer is largely due to an alteration in lifestyle and diet. The antiulcer activity of the aqueous extract of leaves of P. murex on ethanol induced gastric lesions was investigated in our studies. Aqueous extract of leaves extract induced gastric juice at a dose. 200 mg/kg was given to different groups, one hour before the administration of ethanol. Marked gastric mucosal lesions were observed with ethanol. Ulcer index, total acidity, acid volume, total protein and diminution of glutathione was noted. Pretreatment with extract of leaves particularly at a dose of 200 mg/kg in a single and 100 mg/kg for 15 and 30 days treatment and increased the level of glutathione. Therefore the extract of leaves of could be regarded as a favorable anti-ulcer could be attributed to its content of flavonoids and mucilage [10].

The various parts of Abutilon indicum and P. murex such as root, leaves and seeds are documented to possess various medicinal properties. Animal studies were performed using carrgenan induced paw oedema model used wistar rats. The results shoes the methanolic extract is produced higher anti-inflammatory activity at a dose of 400 mg/kg body

Methanolic extract of leaf and fruit was used against 12 different pathogenic microorganisms for their antibacterial activity. The maximum antibacterial activity was noted against gram positive bacteria than gram negative bacteria. Positive control (streptomycin) showed antibacterial activity and there was no inhibition with negative control. More antibacterial activity was observed in methanolic extract against gram positive bacteria Streptococcus progeny and Enterococcus faccalis than the gram negative bacteria [15-16].

Aqueous and alcoholic extract of fruits of P. murex did not show any mortality up to 2000 mg/kg. Significant reduced hepatoprotective activity at 400 mg/kg dose of was observed in alcohol and isoniazide induced liver damage. All the elevated liver biochemical parameters (SGPT, SGOT, TB, TG and TC) in alcohol and isoniazide intoxicated rats decreased significantly near by to normal level by extract of fruits of P. murex. Photomicrograph of liver sections also has shown hepatoprotective activity. Flavonoids and tannins present in aqueous alcoholic extract may be responsible for hepatoprotective action by scavenging free radicals [17-20].

Chronic ethanol exposure may result in testicular damage and infertility in males. Petroleum ether extract of P. murex (PEPM) is evaluated in this study for its ability to increase aphrodisiac activity toethanol induced germ cell damage and infertility in rat models. The effect on fertility factors such as total body weight, percentage of pregnancy, litter size were also significantly increased (P < 0.01) in comparison with the ethanol-treated group. Increases in sperm motility and count were observed in PEPM treated groups in a dose-dependent manner (P < 0.01; P < 0.001) as compared with the plant -treated group [21].

P. murex is a one of the component in prostane, a herbal formulation, and was studied for its efficacy on 5α-reductase inhibition, α-adrenergic antagonistic activity and testosterone-induced prostatic hyperplasia by 5α-reductase inhibition, which was evaluated using rat prostate homogenate as an enzyme source. Adrenergic antagonistic activity was evaluated using isolated rat vas deferens. Experimental prostatic hyperplasia was induced in rats by giving testosterone 3 mg/kg s.c. for 21 days. The prostane dose-dependently inhibited 5α-reductase activity and exhibited α-adrenergic antagonistic activity. The treatment with prostane at 250, 500 and 750 mg/kg body weight, p.o. for 21 days significantly reduced the prostatic weight, the epithelial height and the stromal proliferation in experimental prostatic hypertrophy [22].

Plant drugs and excipients have used importance high synthetic materials because they are nontoxic, low expensive and freely available. The purpose of this study is to search for a cheap and effective natural excipient that can be used as an effective alternative for the formulation of pharmaceutical suspensions. used as a suspending agent. They have low rate of sedimentation, high viscosity, slightly basic pH and are easily redispersible anti diabetic activity. The plant used by the local people as analgedsic and antipyretic activities .the trational uses of this whole plant different parts treated in urinary problems .friuts used to reproductive disorder and enhance fertility activity and diabetics.leaf decotion is used to diabetes.

The alcoholic extract of the fruits of Pedalium murex reduced blood pressure in dog and rat, which was blocked by atropine sulphate. It also caused contraction of the smooth muscle of guinea ileum and rabbit intestine. The decoction of the fruits showed diuretic activity in rats. The alcoholic extract showed abortifacient activity in rats IN alloxin induced diabetics. Oral administration of ethanolic extract at a dose 100 to 200 mg/kg body wt reduced in glucose level and increase in plasma insulin standard drug is glibenclamide [23].