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Development and Characterization of Linagliptin Oral Disintegrating Tablets
Corresponding Author(s) : R. Venkatarao
International Journal of Allied Medical Sciences and Clinical Research,
Vol. 12 No. 1 (2024): 2024 Volume -12 - Issue 1
Abstract
Linagliptin is an anti-diabetic drug used for the treatment of type 2 diabetes, it is belongs to the class of dpp-4 inhibitor. It has long half-life of about 8.6-23.9 hours and hence to achieve immediate therapeutic action it needs immediate release tablet formulation. Among the various techniques using superdisintegrants is a simple approach to formulate immediate release tablets. It undergoes an extensive hepatic first pass metabolism leads to low oral bioavailability (30%). ODT can overcome this problem through improving its bioavailability with an immediate drug release. In the present work, Oral disintegrating tablets of Linagliptin were prepared by direct compression method using superdisintegrants such as Crosspovidone lycoat, and Tulsion. The dispersion time of tablets were reduced with increase in the concentration of super disintegrants like Crosspovidone, lycoat, and Tulsion. From the results obtained, it was concluded that Tulsion was found to be the best among the superdisintegrants, the highest drug release of F9 is 99.45% of the drug in 20 min
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- Seager H. Drug delivery products and the zydis fast dissolving dosage forms. J Pharm Pharmacol. 1998;50(4):375-82. doi: 10.1111/j.2042-7158.1998.tb06876.x, PMID 9625481.
- Chang RK, Guo X, Burnside BA, Couch RA. Fast dissolving tablets. Pharm Technol. 2000;24(6):52-8.
- Dobetti L. Fast melting tablets: developments & Technologies. Pharm Technol. 2001 [Suppl];44.
- Kuchekar BS, Aruagam V. Fast dissolving tablets. Indian J Pharm Edu. 2001;35:150-2.
- Kuchekar BS, Badhan AC, Mahajan HS. Mouth dissolving tablets: A novel drug delivery system. Pharm Times. 2003;35:7-9.
- Bradoo R, Shahani S, Poojary S, Deewan B, Sudarshan S. An observer blind, randomized controlled clinical trial to compare the onset of action, efficacy and safety of cetrizine flash tablets with oral loratidine and cetrizine conventional tablets in allergic rhinitis. JAMA India. 2001;4(10):27-31.
- European Directorate for Quality of medicines. Pharmeuropa. Available from: http://www.pheur.org.
- 1998;10(4):547.
- Udupa N, Venkatesh SM, Venugopal K. Nimesulide dispersible tablets from ’Direct compression’ method. 2001;38(4):208-10.
- Dobetti L. Fast melting tablets: developments & Technologies. Pharm Technol. 2001;11.
- Reddy LH, Ghosh B, Rajneesh. Fast dissolving drug delivery systems: a review of the literature. Indian J Pharm Sci. 2002;7:331-6.
- Lindgreen S, Janzon L. Dysphagia: prevalence of swallowing complaints and clinical findings. Med Clin North Am. 1993;77:3-5.
- Bhushan SY, Sambhaji SP, Anant RP, Kaka Saheb RM. New drug delivery system for elderly. Ind Drugs. 2000;37:312-18.
- Wilson CG, Washington N, Peach J, Murray GR, Kennerley J. The behaviour of a fast-dissolving dosage form (expidet) followed by g-scintigraphy. Int J Pharm. 1987;40(1-2):119-23 (the internet drug index). doi: 10.1016/0378-5173(87)90056-1.
- Goodman and Gilmans pharmacological basis of therapeutics. 10th ed. p. 1030.
- Martindale The complete Drug index 34 Edition page; 1281.
- Ainley W, Paul JW. Handbook of Pharmaceutical excipients. 2nd ed. London: Pharmaceutical Press; 1994. p. 483-86.
- Chowdary KPR, Hymavathi R. Formulation and dissolution rate studies on dispersible tablets of ibuprofen. Indian J Pharm Sci. 2000:213-16.
- Gupta GD, Gaud RS. Formulation and evaluation of nimesulide dispersible tablets using natural disintegrants. Indian J Pharm Sci. 2000;62(5):339-42.
References
Seager H. Drug delivery products and the zydis fast dissolving dosage forms. J Pharm Pharmacol. 1998;50(4):375-82. doi: 10.1111/j.2042-7158.1998.tb06876.x, PMID 9625481.
Chang RK, Guo X, Burnside BA, Couch RA. Fast dissolving tablets. Pharm Technol. 2000;24(6):52-8.
Dobetti L. Fast melting tablets: developments & Technologies. Pharm Technol. 2001 [Suppl];44.
Kuchekar BS, Aruagam V. Fast dissolving tablets. Indian J Pharm Edu. 2001;35:150-2.
Kuchekar BS, Badhan AC, Mahajan HS. Mouth dissolving tablets: A novel drug delivery system. Pharm Times. 2003;35:7-9.
Bradoo R, Shahani S, Poojary S, Deewan B, Sudarshan S. An observer blind, randomized controlled clinical trial to compare the onset of action, efficacy and safety of cetrizine flash tablets with oral loratidine and cetrizine conventional tablets in allergic rhinitis. JAMA India. 2001;4(10):27-31.
European Directorate for Quality of medicines. Pharmeuropa. Available from: http://www.pheur.org.
1998;10(4):547.
Udupa N, Venkatesh SM, Venugopal K. Nimesulide dispersible tablets from ’Direct compression’ method. 2001;38(4):208-10.
Dobetti L. Fast melting tablets: developments & Technologies. Pharm Technol. 2001;11.
Reddy LH, Ghosh B, Rajneesh. Fast dissolving drug delivery systems: a review of the literature. Indian J Pharm Sci. 2002;7:331-6.
Lindgreen S, Janzon L. Dysphagia: prevalence of swallowing complaints and clinical findings. Med Clin North Am. 1993;77:3-5.
Bhushan SY, Sambhaji SP, Anant RP, Kaka Saheb RM. New drug delivery system for elderly. Ind Drugs. 2000;37:312-18.
Wilson CG, Washington N, Peach J, Murray GR, Kennerley J. The behaviour of a fast-dissolving dosage form (expidet) followed by g-scintigraphy. Int J Pharm. 1987;40(1-2):119-23 (the internet drug index). doi: 10.1016/0378-5173(87)90056-1.
Goodman and Gilmans pharmacological basis of therapeutics. 10th ed. p. 1030.
Martindale The complete Drug index 34 Edition page; 1281.
Ainley W, Paul JW. Handbook of Pharmaceutical excipients. 2nd ed. London: Pharmaceutical Press; 1994. p. 483-86.
Chowdary KPR, Hymavathi R. Formulation and dissolution rate studies on dispersible tablets of ibuprofen. Indian J Pharm Sci. 2000:213-16.
Gupta GD, Gaud RS. Formulation and evaluation of nimesulide dispersible tablets using natural disintegrants. Indian J Pharm Sci. 2000;62(5):339-42.