The potential of tomato extract as a companion to anti-hypertensive drugs in obstetric services for hypertension in pregnancy
Corresponding Author(s) : Rayi Al Hay Surahman
rayialhays@gmail.com
International Journal of Allied Medical Sciences and Clinical Research,
Vol. 2021 No. 9 (4): 2021 Volume - 9 Issue - 4
Abstract
Hypertension in pregnancy has been treated for decades with pharmacological therapy, but it can result in side effects. Non-pharmacological therapy is most commonly used as an alternative drug as well as a companion therapy to reduce the side effects. Tomato extract, which contains potassium and lycopene, is a non-pharmacological therapy that can lower maternal blood pressure in patients with hypertension.
Purposes: This study aimed to analyze the potential of a tomato extract (solanum lycopersicum) as an anti-hypertensive drug companion to help repair blood pressure and potassium levels in pregnant women with hypertension.
Methods: This study is a quasi-experiment with a pretest-posttest with control group design. Purposive sampling technique was employed, with 32 respondents divided into intervention and control groups. A Friedmann Test and a Paired Sample T-Test were employed in the statistical analysis.
Result: Systolic blood pressure drops by 16.8 mmHg in the intervention group and 4.0 mmHg in the control group, with a p-value 0.000. Diastolic blood group intervention decreases by 9.6 mmHg and control group decreases by 7.9 mmHg, with a p-value 0.000.
Purposes: This study aimed to analyze the potential of a tomato extract (solanum lycopersicum) as an anti-hypertensive drug companion to help repair blood pressure and potassium levels in pregnant women with hypertension.
Methods: This study is a quasi-experiment with a pretest-posttest with control group design. Purposive sampling technique was employed, with 32 respondents divided into intervention and control groups. A Friedmann Test and a Paired Sample T-Test were employed in the statistical analysis.
Result: Systolic blood pressure drops by 16.8 mmHg in the intervention group and 4.0 mmHg in the control group, with a p-value 0.000. Diastolic blood group intervention decreases by 9.6 mmHg and control group decreases by 7.9 mmHg, with a p-value 0.000.
Keywords
Tomato extract
pregnant women
hypertension
potassium
1.
Rayi Al Hay Surahman, Sri Sumarni, Supriyana. The potential of tomato extract as a companion to anti-hypertensive drugs in obstetric services for hypertension in pregnancy. Int. J. of Allied Med. Sci. and Clin. Res. [Internet]. 2021 Dec. 17 [cited 2025 Nov. 12];2021(9):712-5. Available from: https://ijamscr.com/ijamscr/article/view/1119
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References
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5. El Mashad HM, Zhao L, Zhang R, Pan Z. Tomato. In: Integrated Processing Technologies for Food and Agricultural By-Products. 2019.
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7. Wolak T, Sharoni Y, Levy J, Linnewiel-Hermoni K, Stepensky D, Paran E. Effect of tomato nutrient complex on blood pressure: A double blind, randomized dose–response study. Nutrients. 2019;11(5).
8. Togarikar SM. Efficacy of methyldopa versus nifedipine in mild and severe pregnancy induced hypertension. Int J Reprod Contraception, Obstet Gynecol. 2017;6(10):4544.
9. Ainurrafiq A, Risnah R, Ulfa Azhar M. Terapi Non Farmakologi dalam Pengendalian Tekanan Darah Pada Pasien Hipertensi: Systematic Review. MPPKI (Media Publ Promosi Kesehat Indones Indones J Heal Promot. 2019;
10. Kusumastuty I, Widyani D, Sri Wahyuni E. Asupan Protein dan Kalium Berhubungan dengan Penurunan Tekanan Darah Pasien Hipertensi Rawat Jalan (Protein and Potassium Intake Related to Decreased Blood Pressure in Outclinic Hypertensive Patients). Indones J Hum Nutr. 2016;
11. Potensi Likopen dalam Tomat untuk Kesehatan. Bul Teknol Pasca Panen. 2016; aaq
References
1. World Health Organization. Maternal mortality?: level and trends 2000 to 2017. Sexual and Reproductive Health. 2019. 12 p. Available from: https://www.who.int/reproductivehealth/publications/maternal-mortality-2000-2017/en/
2. Prawirohardjo S. Ilmu kebidanan edisi keempat. PT Bina Pustaka Sarwono Prawirohardjo, Jakarta. 2014;
3. Kandarini Y. Tatalaksana Farmakologi Terapi Hipertensi. Div Ginjal dan Hipertens RSUP Sanglah Denpasar. 2017;
4. Chagan L, Bernstein D, Cheng JWM, Kirschenbaum HL, Rozenfeld V, Caliendo GC, et al. Use of biological based therapy in patients with cardiovascular diseases in a university-hospital in New York City. BMC Complement Altern Med. 2005;5:1–10.
5. El Mashad HM, Zhao L, Zhang R, Pan Z. Tomato. In: Integrated Processing Technologies for Food and Agricultural By-Products. 2019.
6. Ilma AD, Wirawanni Y. Pengaruh Pemberian Jus Mentimun Dan Tomat Terhadap Tekanan Darah Perempuan Overweight Dan Obesitas. J Nutr Coll. 2015;4(3):281–7.
7. Wolak T, Sharoni Y, Levy J, Linnewiel-Hermoni K, Stepensky D, Paran E. Effect of tomato nutrient complex on blood pressure: A double blind, randomized dose–response study. Nutrients. 2019;11(5).
8. Togarikar SM. Efficacy of methyldopa versus nifedipine in mild and severe pregnancy induced hypertension. Int J Reprod Contraception, Obstet Gynecol. 2017;6(10):4544.
9. Ainurrafiq A, Risnah R, Ulfa Azhar M. Terapi Non Farmakologi dalam Pengendalian Tekanan Darah Pada Pasien Hipertensi: Systematic Review. MPPKI (Media Publ Promosi Kesehat Indones Indones J Heal Promot. 2019;
10. Kusumastuty I, Widyani D, Sri Wahyuni E. Asupan Protein dan Kalium Berhubungan dengan Penurunan Tekanan Darah Pasien Hipertensi Rawat Jalan (Protein and Potassium Intake Related to Decreased Blood Pressure in Outclinic Hypertensive Patients). Indones J Hum Nutr. 2016;
11. Potensi Likopen dalam Tomat untuk Kesehatan. Bul Teknol Pasca Panen. 2016; aaq
2. Prawirohardjo S. Ilmu kebidanan edisi keempat. PT Bina Pustaka Sarwono Prawirohardjo, Jakarta. 2014;
3. Kandarini Y. Tatalaksana Farmakologi Terapi Hipertensi. Div Ginjal dan Hipertens RSUP Sanglah Denpasar. 2017;
4. Chagan L, Bernstein D, Cheng JWM, Kirschenbaum HL, Rozenfeld V, Caliendo GC, et al. Use of biological based therapy in patients with cardiovascular diseases in a university-hospital in New York City. BMC Complement Altern Med. 2005;5:1–10.
5. El Mashad HM, Zhao L, Zhang R, Pan Z. Tomato. In: Integrated Processing Technologies for Food and Agricultural By-Products. 2019.
6. Ilma AD, Wirawanni Y. Pengaruh Pemberian Jus Mentimun Dan Tomat Terhadap Tekanan Darah Perempuan Overweight Dan Obesitas. J Nutr Coll. 2015;4(3):281–7.
7. Wolak T, Sharoni Y, Levy J, Linnewiel-Hermoni K, Stepensky D, Paran E. Effect of tomato nutrient complex on blood pressure: A double blind, randomized dose–response study. Nutrients. 2019;11(5).
8. Togarikar SM. Efficacy of methyldopa versus nifedipine in mild and severe pregnancy induced hypertension. Int J Reprod Contraception, Obstet Gynecol. 2017;6(10):4544.
9. Ainurrafiq A, Risnah R, Ulfa Azhar M. Terapi Non Farmakologi dalam Pengendalian Tekanan Darah Pada Pasien Hipertensi: Systematic Review. MPPKI (Media Publ Promosi Kesehat Indones Indones J Heal Promot. 2019;
10. Kusumastuty I, Widyani D, Sri Wahyuni E. Asupan Protein dan Kalium Berhubungan dengan Penurunan Tekanan Darah Pasien Hipertensi Rawat Jalan (Protein and Potassium Intake Related to Decreased Blood Pressure in Outclinic Hypertensive Patients). Indones J Hum Nutr. 2016;
11. Potensi Likopen dalam Tomat untuk Kesehatan. Bul Teknol Pasca Panen. 2016; aaq