A review: self emulsifying drug delivery system

Abstract

Most favorite route of drug administration is the oral route for administration for many formulations and has dominated over all other routes of administrations. The main disadvantage of oral drug formulations is low and unpredictable bioavailability that results from unfortunate aqueous solubility. Nearly about 42% of upcoming chemical molecules show bad water solubility that is the main problem for modern drug delivery system, just because of their low bioavailability. The current study is basically on the purpose of to formulate a Self Emulsifying Drug Delivery System which enclose lipophilic drug. Many drugs like loratadine wich exploring the potential of transporter for such system. The self micro emulsifying drug delivery systems is the one isotropic mixture of oil with surfactant as well as with co- surfactant and drug with a distinctive capability for forming fine oil in water micro-emulsion in the lead to mild shakeup following dilution along aqueous phase. When compared to other techniques self emulsifying drug delivery system came up with strong attention just because of enhanced oral bioavailability enabling decrease in dose amount, High steady sequential profiles of drug absorption and the size of particle of formulations may influenced by type of oil, as that liquid paraffin made small size of particle which may ranges below 2 microns.