A Review: Self Emulsifying Drug Delivery System
Corresponding Author(s) : Sita Kumari
madhusita123@gmail.com
International Journal of Allied Medical Sciences and Clinical Research,
Vol. 2021 No. 9 (4): 2021 Volume - 9 Issue - 4
Abstract
Most favorite route of drug administration is the oral route for administration for many formulations and has dominated over all other routes of administrations. The main disadvantage of oral drug formulations is low and unpredictable bioavailability that results from unfortunate aqueous solubility. Nearly about 42% of upcoming chemical molecules show bad water solubility that is the main problem for modern drug delivery system, just because of their low bioavailability. The current study is basically on the purpose of to formulate a Self Emulsifying Drug Delivery System which enclose lipophilic drug. Many drugs like loratadine wich exploring the potential of transporter for such system. The self micro emulsifying drug delivery systems is the one isotropic mixture of oil with surfactant as well as with co- surfactant and drug with a distinctive capability for forming fine oil in water micro-emulsion in the lead to mild shakeup following dilution along aqueous phase. When compared to other techniques self emulsifying drug delivery system came up with strong attention just because of enhanced oral bioavailability enabling decrease in dose amount, High steady sequential profiles of drug absorption and the size of particle of formulations may influenced by type of oil, as that liquid paraffin made small size of particle which may ranges below 2 microns.
Keywords
Self emulsifying drug delivery system
lipid based formulations
oral bioavailability
poorly water soluble drugs
1.
Dr. Mayank Bansal, Jitendra Kumar, Deeksha Sharma, Sita Kumari. A Review: Self Emulsifying Drug Delivery System. Int. J. of Allied Med. Sci. and Clin. Res. [Internet]. 2021 Nov. 17 [cited 2026 May 2];2021(9):657-60. Available from: https://ijamscr.com/ijamscr/article/view/1102
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References
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1. Amidon, G.., et.al. A theoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability, Pharm.Res. 1995; 12: 413-420.
2. A.T.M. Serajuddin, et al. Effect of vehicle amphiphilicity on the dissolution and bioavailability of a poorly watersoluble drug from solid dispersion, J. Pharm. Sci. 1988; 77: 414-417.
3. Bamba, J. et al. (1995) Cryoprotection of emulsions in freeze-drying: freezing process analysis. Drug. Dev. Ind. Pharm. 21, 1749–1760
4. Christensen, K.L. et al. (2001) Technical optimization of redispersible dry emulsions. Int. J. Pharm. 212, 195–202
5. El-Kamel AH, et al. Preparation and evaluation of ketoprofen floating oral delivery system. Int J Pharm. 2001; 220:13-21
6. Hansen, T. et al. (2004) Process characteristics and compaction of spray-dried emulsions containing a drug dissolved in lipid. Int. J. Pharm. 287, 55–66
7. Jang, D.J. et al. (2006) Improvement of bioavailability and photostability of amlodipine using redispersible dry emulsion. Eur. J. Pharm. Sci. 28, 405–411
8. Khoo SM, Humberstone AJ, Porter CJ, Edwards GA and Charman WN. Formulation design and bioavailability assessment of lipidic self-emulsifyingFormulations of Halofantrine. Int J of Pharm 1998; 167: 155-164
9. Myers, S.L. and Shively, M.L. (1992) Preparation and characterization of emulsifiable glasses: oil-in-water and water-in-oil-in-water emulsion. J. Colloid Interface Sci. 149, 271–278
10. Pouton CW, Charman WN. The potential of oily formulations for drug delivery to the gastro-intestinal tract. Adv Drug Deliv Rev. 1997; 25:1-2.
11. Patil P, Joshij, paradkar. Effect of formulatiuon variables on preparation and evaluation of gelled self- emulsifying drug delivery system (SEDDS) of ketoprofen.AAPS Pharm Sci Tech.2004; 5(3):34-42
12. Patil p, Vandana p, paradkar p formulation of selfemulsifying drug delivery system for oraldelivery of simvastatin: In vitro and in vivo evaluation. Acta pharma. 2007; 57: 111-122
13. Rhee Y-S, et al. Transdermal delivery of ketoprofen using microemulsions. Int J Pharm. 2001; 228:161-170
14. Roda A, et al. Bioavailability of a new ketoprofen formulation for once-daily oral administration. Int J Pharm. 2002;241:165-172.
15. S. Shafiq, et al. Development and bioavailability assessment of ramipril nanoemulsion formulation Eur. J. Pharm. Biopharm 2007; 66: 227–243
16. Toorisaka, E. et al. (2005) an enteric-coated dry emulsion formulation for oral insulin delivery. J. Control Release 107, 91–96
17. Vergote GJ, et al. An oral controlled release matrix pelletformulation containing nanocrystalline ketoprofen. Int J Pharm. 2001; 219:81-87.
18. Vergote GJ, et al. An oral controlled release matrix pellet formulation containingnanocrystalline ketoprofen. Int J Pharm. 2001; 219:81-87.
19. Yamada T, Onishi H, Machida Y. Sustained release ketoprofen microparticles with ethylcellulose and carboxymethylethylcellulose. J Control Release. 2001;75:271-282
References
1. Amidon, G.., et.al. A theoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability, Pharm.Res. 1995; 12: 413-420.
2. A.T.M. Serajuddin, et al. Effect of vehicle amphiphilicity on the dissolution and bioavailability of a poorly watersoluble drug from solid dispersion, J. Pharm. Sci. 1988; 77: 414-417.
3. Bamba, J. et al. (1995) Cryoprotection of emulsions in freeze-drying: freezing process analysis. Drug. Dev. Ind. Pharm. 21, 1749–1760
4. Christensen, K.L. et al. (2001) Technical optimization of redispersible dry emulsions. Int. J. Pharm. 212, 195–202
5. El-Kamel AH, et al. Preparation and evaluation of ketoprofen floating oral delivery system. Int J Pharm. 2001; 220:13-21
6. Hansen, T. et al. (2004) Process characteristics and compaction of spray-dried emulsions containing a drug dissolved in lipid. Int. J. Pharm. 287, 55–66
7. Jang, D.J. et al. (2006) Improvement of bioavailability and photostability of amlodipine using redispersible dry emulsion. Eur. J. Pharm. Sci. 28, 405–411
8. Khoo SM, Humberstone AJ, Porter CJ, Edwards GA and Charman WN. Formulation design and bioavailability assessment of lipidic self-emulsifyingFormulations of Halofantrine. Int J of Pharm 1998; 167: 155-164
9. Myers, S.L. and Shively, M.L. (1992) Preparation and characterization of emulsifiable glasses: oil-in-water and water-in-oil-in-water emulsion. J. Colloid Interface Sci. 149, 271–278
10. Pouton CW, Charman WN. The potential of oily formulations for drug delivery to the gastro-intestinal tract. Adv Drug Deliv Rev. 1997; 25:1-2.
11. Patil P, Joshij, paradkar. Effect of formulatiuon variables on preparation and evaluation of gelled self- emulsifying drug delivery system (SEDDS) of ketoprofen.AAPS Pharm Sci Tech.2004; 5(3):34-42
12. Patil p, Vandana p, paradkar p formulation of selfemulsifying drug delivery system for oraldelivery of simvastatin: In vitro and in vivo evaluation. Acta pharma. 2007; 57: 111-122
13. Rhee Y-S, et al. Transdermal delivery of ketoprofen using microemulsions. Int J Pharm. 2001; 228:161-170
14. Roda A, et al. Bioavailability of a new ketoprofen formulation for once-daily oral administration. Int J Pharm. 2002;241:165-172.
15. S. Shafiq, et al. Development and bioavailability assessment of ramipril nanoemulsion formulation Eur. J. Pharm. Biopharm 2007; 66: 227–243
16. Toorisaka, E. et al. (2005) an enteric-coated dry emulsion formulation for oral insulin delivery. J. Control Release 107, 91–96
17. Vergote GJ, et al. An oral controlled release matrix pelletformulation containing nanocrystalline ketoprofen. Int J Pharm. 2001; 219:81-87.
18. Vergote GJ, et al. An oral controlled release matrix pellet formulation containingnanocrystalline ketoprofen. Int J Pharm. 2001; 219:81-87.
19. Yamada T, Onishi H, Machida Y. Sustained release ketoprofen microparticles with ethylcellulose and carboxymethylethylcellulose. J Control Release. 2001;75:271-282
2. A.T.M. Serajuddin, et al. Effect of vehicle amphiphilicity on the dissolution and bioavailability of a poorly watersoluble drug from solid dispersion, J. Pharm. Sci. 1988; 77: 414-417.
3. Bamba, J. et al. (1995) Cryoprotection of emulsions in freeze-drying: freezing process analysis. Drug. Dev. Ind. Pharm. 21, 1749–1760
4. Christensen, K.L. et al. (2001) Technical optimization of redispersible dry emulsions. Int. J. Pharm. 212, 195–202
5. El-Kamel AH, et al. Preparation and evaluation of ketoprofen floating oral delivery system. Int J Pharm. 2001; 220:13-21
6. Hansen, T. et al. (2004) Process characteristics and compaction of spray-dried emulsions containing a drug dissolved in lipid. Int. J. Pharm. 287, 55–66
7. Jang, D.J. et al. (2006) Improvement of bioavailability and photostability of amlodipine using redispersible dry emulsion. Eur. J. Pharm. Sci. 28, 405–411
8. Khoo SM, Humberstone AJ, Porter CJ, Edwards GA and Charman WN. Formulation design and bioavailability assessment of lipidic self-emulsifyingFormulations of Halofantrine. Int J of Pharm 1998; 167: 155-164
9. Myers, S.L. and Shively, M.L. (1992) Preparation and characterization of emulsifiable glasses: oil-in-water and water-in-oil-in-water emulsion. J. Colloid Interface Sci. 149, 271–278
10. Pouton CW, Charman WN. The potential of oily formulations for drug delivery to the gastro-intestinal tract. Adv Drug Deliv Rev. 1997; 25:1-2.
11. Patil P, Joshij, paradkar. Effect of formulatiuon variables on preparation and evaluation of gelled self- emulsifying drug delivery system (SEDDS) of ketoprofen.AAPS Pharm Sci Tech.2004; 5(3):34-42
12. Patil p, Vandana p, paradkar p formulation of selfemulsifying drug delivery system for oraldelivery of simvastatin: In vitro and in vivo evaluation. Acta pharma. 2007; 57: 111-122
13. Rhee Y-S, et al. Transdermal delivery of ketoprofen using microemulsions. Int J Pharm. 2001; 228:161-170
14. Roda A, et al. Bioavailability of a new ketoprofen formulation for once-daily oral administration. Int J Pharm. 2002;241:165-172.
15. S. Shafiq, et al. Development and bioavailability assessment of ramipril nanoemulsion formulation Eur. J. Pharm. Biopharm 2007; 66: 227–243
16. Toorisaka, E. et al. (2005) an enteric-coated dry emulsion formulation for oral insulin delivery. J. Control Release 107, 91–96
17. Vergote GJ, et al. An oral controlled release matrix pelletformulation containing nanocrystalline ketoprofen. Int J Pharm. 2001; 219:81-87.
18. Vergote GJ, et al. An oral controlled release matrix pellet formulation containingnanocrystalline ketoprofen. Int J Pharm. 2001; 219:81-87.
19. Yamada T, Onishi H, Machida Y. Sustained release ketoprofen microparticles with ethylcellulose and carboxymethylethylcellulose. J Control Release. 2001;75:271-282