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  <front>
    <article-meta>
      <title-group>
        <article-title>Correlation between squamous blepharitis and scalp dandruff </article-title>
      </title-group>
      <contrib-group content-type="author">
        <contrib contrib-type="person">
          <name>
            <given-names>Dr.C.Xavier Jayaseelan</given-names>
          </name>
          <email>ijamscr@gmail.com</email>
          <xref ref-type="aff" rid="aff-1"/>
        </contrib>
      </contrib-group>
      <aff id="aff-1">
        <institution>Department Of Ophthalmology, Saveetha Medical College &amp; Hospital, Chennai, Tamilnadu, India.</institution>
        <country>India</country>
      </aff>
      <history>
        <date date-type="received" iso-8601-date="2020-08-12">
          <day>12</day>
          <month>08</month>
          <year>2020</year>
        </date>
        <date data-type="published" iso-8601-date="2020-08-12">
          <day>12</day>
          <month>08</month>
          <year>2020</year>
        </date>
      </history>
    </article-meta>
  </front>
  <body>
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    <p>
      <bold>
        <italic>IJAMSCR |Volume </italic>
      </bold>
      <bold>
        <italic>7</italic>
      </bold>
      <bold>
        <italic> | Issue </italic>
      </bold>
      <bold>
        <italic>2</italic>
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      <bold>
        <italic> | </italic>
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      <bold>
        <italic>Apr - Jun</italic>
      </bold>
      <bold>
        <italic>–</italic>
      </bold>
      <bold>
        <italic> 201</italic>
      </bold>
      <bold>
        <italic>9</italic>
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    <p>
      <bold>www.ijamscr.com</bold>
    </p>
    <p><bold><italic>Research article</italic></bold><bold><italic>                                                                                             Medical research</italic></bold></p>
    <p>
      <bold>Correlation between squamous blepharitis and scalp dandruff</bold>
    </p>
    <p>
      <bold>Kisshore Kumar G (3</bold>
      <bold>
        <sup>rd</sup>
      </bold>
      <bold> Year </bold>
      <bold>MBBS</bold>
      <bold>), Dr.C.XavierJayaseelan</bold>
    </p>
    <p>
      <italic>Department Of Ophthalmology, Saveetha Medical College &amp;</italic>
      <italic>Hospital,</italic>
      <italic>Chennai,</italic>
      <italic>Tamilnadu,</italic>
      <italic>India.</italic>
    </p>
    <p>
      <bold>*</bold>
      <bold>Principal </bold>
      <bold>Investigator</bold>
      <bold>:</bold>
      <bold>Kisshore Kumar G</bold>
    </p>
    <p>
      <bold>*</bold>
      <bold>Corresponding author: </bold>
      <bold>Dr.C.Xavier</bold>
      <bold>Jayaseelan</bold>
    </p>
    <p>
      <bold>Abstract</bold>
    </p>
    <p>
      <bold>Background</bold>
    </p>
    <p>Blepharitis is one of the most common ocular conditions for which the patient visits the ophthalmologist. This study was conducted with objective to determine the correlation between Squamous Blepharitis and Scalp Dandruff in patients presenting to the Outpatient Department (OPD) of Ophthalmology, Saveetha Medical College &amp;Hospital, Chennai.</p>
    <p>
      <bold>Methods</bold>
    </p>
    <p>A hospital based cross-sectional study was carried out from January 2019 to march 2019 among 188 patients with squamous blepharitis. Data was collected by examination of the study subject by ophthalmologist &amp; if necessary by dermatologist after taking informed consent.</p>
    <p>
      <bold>Results</bold>
    </p>
    <p>The study shows that there is a significant association between scalp dandruff and squamous blepharitis. Among the study subjects (those who are having squamous blepharitis), a higher proportion of female (24.4%) were found to have scalp dandruff when compared to male (17.0%). The p value shows there is significant association between scalp dandruff and squamous blepharitis among the age groups <bold>(p value – 0.007)</bold> but there is no significant association between scalp dandruff and squamous blepharitis among the sex<bold>(p value - 0.88).</bold></p>
    <p>
      <bold>Conclusion</bold>
    </p>
    <p>This study revealed that scalp dandruff was one of the important cause for the squamous blepharitis and it is one of the common ocular condition for which the patient consults the Ophthalmologist. Early detection of seborrheic scalp infection, usually the source of lid-margin infection, has been helpful in the prevention &amp; treatment of the related blepharitis.</p>
    <sec id="sec-1"/>
    <sec id="sec-2"/>
    <sec id="sec-3">
      <title>INTRODUCTION</title>
      <p>Blepharitis is one of the most common ocular conditions characterized by redness, scaling inflammation and crusting of the eyelid margin and it is a common cause of discomfort and irritation among people of all ages, ethnicity and sex. The term blepharitis:-<bold>blepharon</bold> means the eyelids &amp;<bold>-itis</bold> refers to inflammation. This is a sub-acute or chronic inflammation of the eye-lid margins, appearing as a simple hyperaemia or as a true inflammation [19, 20], which may occur in two forms: anterior &amp; posterior. The anterior may be <bold>(i) seborrhoeic (or) squamous</bold>&amp; (ii) ulcerative and sometimes occasionally, parasite causes blepharitis - blepharitisacarica due to demodexfolliculorum and phthiriasispalpebrarum due to the crab louse , very rarely to the head louse &amp; other diseases or condition that lead to blepharitis are : rosacea, herpes simplex dermatitis, varicella-zoster dermatitis, molluscumcontagiosum, allergic dermatitis, contact dermatitis. It can also be divided into the following clinical types: (i) bacterial blepharitis, (ii) seborrhoeic or squamous blepharitis, (iii) mixed staphylococcal with seborrhoeicblepharitis, (iv) posteriorblepharitis or meibomitis and (v) parasitic blepharitis. Almost any inflammatory condition which affects the skin in general may attack the eyelids and oedema of the lids are common due to the looseness of the subcutaneous tissue. In general, blepharitis is not a sight-threatening condition, but if left untreated it has the potential to cause keratopathy, ulceration, chronic conjuctivitis and permanent alteration in eyelid anatomy [16-18]. </p>
      <p>Seborrheic Dermatitis (SD) and dandruff are common dermatological problems that affect the seborrheic areas of the body. They are considered the same basic condition sharing many features and responding to similar treatment, differing only in locality and severity. Dandruff is restricted to the scalp, and involves itchy, flaking skin without visible inflammation. Seborrheic Dermatitis affects the scalp as well as face, retro-auricular area &amp; the upper chest, causing flaking, scaling, inflammation and pruritus, and can have marked erythema. Flaking in Seborrheic Dermatitis and dandruff is usually white-to-yellowish, and may be oily or dry. It is estimated that Seborrheic Dermatitis and dandruff combined affect half of the adult population. Despite such high prevalence, their etiology is not well understood. Various intrinsic and environmental factors, such as sebaceous secretions, skin surface fungal colonization, individual susceptibility, and interactions between these factors, all contribute to the pathogenesis and it is considered as one of the eiology for seborrheicblepharitis [1]. Although there are many studies available on blepharitis, a very few hospital-based studies are available on squamous blepharitis. With this background, the present study was designed to estimate the correlation between squamous blepharitis and scalp dandruff in The <bold>Out-Patient Department of Ophthalmology at Saveetha Medical College &amp; Hospital, Chennai </bold>[2-5]<bold>.</bold></p>
    </sec>
    <sec id="sec-4">
      <title>METHODOLOGY</title>
      <p>A hospital based cross-sectional study was conducted in the Outpatient Department (OPD) of Ophthalmology Dept, Saveetha Medical College &amp; Hospital, Chennai from January 2019 to March 2019. All the patients attending Ophthalmology OPD on working days during the study period were included in the study by convenient sampling method. The uncooperative and those who were not interested were excluded from the study. A total of 188 patients with squamous blepharitis formed the study population [10-15].</p>
      <p>Ethical clearance was obtained from the Institutional Ethics Committee of the college before conducting the study. Informed verbal consent was taken from the participants or guardian of the study participants. Data like name, age, sex, socio-demographic profile was collected from the study participants or from their guardians. All the patients were examined by ophthalmologists and wherever necessary, dandruff of scalp was confirmed by the dermatologist. The information and presenting features like scales at the lid margin, irritation, discomfort and falling of eyelashes, etc was recored by examination of the study subject. The collected data was entered onto the excel sheet and it was analysed by appropriate statistical methods by using spss software and the p value was identified [6-9].</p>
    </sec>
    <sec id="sec-5"/>
    <sec id="sec-6">
      <title>RESULTS</title>
      <p>A total of 188 patients with squamous blepharitis were choosen. Out of total study population, the population of <bold>males</bold><bold>(48.4%) </bold>and females<bold>(51.5%</bold><bold>) </bold>in the <bold>ratio 1:1.06. </bold>188 study subjects who had squamous blepharitis are grouped under 4 categories: 1.Category 1 (0-20years)-17.6%, 2.Category 2 (20-40years)-47.3%, 3.Category 3 (40-60years)-28.7%, 4.Category 4 (&gt;60years)-6.4%. Further the category was sub classified to <bold>MALES</bold> and <bold>FEMALES </bold>and among them presence and absence of scalp dandruff was identified.<bold> Out of the 188 subjects with </bold><bold>squamous blepharitis, 78 were found to have scalp dandruff and it was confirmed by dermatologist.</bold></p>
    </sec>
    <sec id="sec-7">
      <title>DISTRIBUTION AMONG MALE</title>
      <table-wrap>
        <table>
          <tr>
            <td>
              <bold>RISK FACTOR</bold>
            </td>
            <td>
              <bold>0-20YRS</bold>
            </td>
            <td>
              <bold>20-40YRS</bold>
            </td>
            <td>
              <bold>40-60YRS</bold>
            </td>
            <td>
              <bold>&gt;60YRS</bold>
            </td>
            <td>
              <bold>TOTAL</bold>
            </td>
          </tr>
          <tr>
            <td>
              <bold>SCALP DANDRUFF (+)</bold>
            </td>
            <td>4</td>
            <td>11</td>
            <td>15</td>
            <td>2</td>
            <td>32</td>
          </tr>
          <tr>
            <td>
              <bold>SCALP DANDRUFF (-)</bold>
            </td>
            <td>14</td>
            <td>30</td>
            <td>11</td>
            <td>4</td>
            <td>59</td>
          </tr>
          <tr>
            <td>
              <bold>TOTAL</bold>
            </td>
            <td>18</td>
            <td>41</td>
            <td>26</td>
            <td>6</td>
            <td>91</td>
          </tr>
        </table>
      </table-wrap>
      <fig>
        <graphic mimetype="image" mime-subtype="png" xlink:href="image2.png"/>
      </fig>
      <p>
        <bold>This Figure Illustrates That How Many Male Subjects (Squamous Blepharitis Patients) Were Having Scalp Dandruff</bold>
      </p>
    </sec>
    <sec id="sec-8">
      <title>DISTRIBUTION AMONG FEMALE</title>
      <table-wrap>
        <table>
          <tr>
            <td>
              <bold>RISK FACTOR</bold>
            </td>
            <td>
              <bold>0-20YRS</bold>
            </td>
            <td>
              <bold>20-40YRS</bold>
            </td>
            <td>
              <bold>40-60YRS</bold>
            </td>
            <td>
              <bold>&gt;60YRS</bold>
            </td>
            <td>
              <bold>TOTAL</bold>
            </td>
          </tr>
          <tr>
            <td>
              <bold>SCALP DANDRUFF (+)</bold>
            </td>
            <td>4</td>
            <td>21</td>
            <td>16</td>
            <td>5</td>
            <td>46</td>
          </tr>
          <tr>
            <td>
              <bold>SCALP DANDRUFF (-)</bold>
            </td>
            <td>11</td>
            <td>27</td>
            <td>12</td>
            <td>1</td>
            <td>51</td>
          </tr>
          <tr>
            <td>
              <bold>TOTAL</bold>
            </td>
            <td>15</td>
            <td>48</td>
            <td>28</td>
            <td>6</td>
            <td>97</td>
          </tr>
        </table>
      </table-wrap>
      <p>
        <bold>This Figure Illustrates That How Many Female Subjects (Squamous Blepharitis Patients) Were Having Scalp Dandruff</bold>
      </p>
    </sec>
    <sec id="sec-9">
      <title>DISTRIBUTION AMONG AGE GROUPS</title>
      <table-wrap>
        <table>
          <tr>
            <td>
              <bold>RISK FACTOR</bold>
            </td>
            <td>
              <bold>0-20YRS</bold>
            </td>
            <td>
              <bold>20-40YRS</bold>
            </td>
            <td>
              <bold>40-60YRS</bold>
            </td>
            <td>
              <bold>&gt;60YRS</bold>
            </td>
            <td>
              <bold>TOTAL</bold>
            </td>
          </tr>
          <tr>
            <td>
              <bold>SCALP DANDRUFF (+)</bold>
            </td>
            <td>8</td>
            <td>32</td>
            <td>31</td>
            <td>7</td>
            <td>78</td>
          </tr>
          <tr>
            <td>
              <bold>SCALP DANDRUFF (-)</bold>
            </td>
            <td>25</td>
            <td>57</td>
            <td>23</td>
            <td>5</td>
            <td>110</td>
          </tr>
          <tr>
            <td>
              <bold>TOTAL</bold>
            </td>
            <td>33</td>
            <td>89</td>
            <td>54</td>
            <td>12</td>
            <td>91</td>
          </tr>
        </table>
      </table-wrap>
      <p>
        <bold>This Figure Illustrates Distribution </bold>
        <bold>of</bold>
        <bold> Scalp Dandruff </bold>
        <bold>among</bold>
        <bold> Squamous Blepharitis Patients</bold>
      </p>
      <p>No.of cases positive for scalp dandruff between 0-20 years of age: 8 out of 33 patients.</p>
      <p>No.of cases positive for scalp dandruff between 20-40 years of age: 32 out of 89 patients.</p>
      <p>No.of cases positive for scalp dandruff between 40-60 years of age: 31 out of 54 patients.</p>
      <p>No.of cases positive for scalp dandruff between &gt;60 years of age: 7 out of 12 patients.</p>
      <p>Among the study subjects (those who are having squamous blepharitis, a higher proportion of <bold>female</bold><bold>(24.4%)</bold> were founded to have scalp dandruff when compared to <bold>male</bold><bold>(17.0%). The p value shows there is </bold>significant association between scalp dandruff and squamous blepharitis among the age groups <bold>(p value – 0.007)</bold> but there is no significant association between scalp dandruff and squamous blepharitis among the sex <bold>(p value - 0.88)</bold>.</p>
    </sec>
    <sec id="sec-10"/>
    <sec id="sec-11">
      <title>DISCUSSION</title>
      <p>Squamous blepharitis -primarily, it is a anterior blepharitis and it is usually associated with seborrhea of scalp (dandruff) &amp; it is often essentially metabolic. It is characterized by deposition of whitish-materials (soft scales), irritation, discomfort, sometimes watering, falling of eyelashes and thickening of lid margins. If the scales are removed the underlying surface is found to be hyperaemic but not ulcerative which is used to differentiate from the staphylococcal type where the base of it bleeds easily &amp; ulcers covered by yellow crusts at the root of the cilia. The p value shows that there is significant association between scalp dandruff and squamous blepharitis among the age groups but there is no significant association between scalp dandruff and squamous blepharitis among the sex.</p>
    </sec>
    <sec id="sec-12"/>
    <sec id="sec-13">
      <title>CONCLUSION</title>
      <p>This study revealed that scalp dandruff was one of the important cause for the squamous blepharitis and it is one of the common ocular condition for which the patient consults the ophthalmologist. Early detection of seborrheic scalp infection, usually the source of lid-margin infection,has been helpful in the prevention &amp; treatment of the related blephartis.</p>
    </sec>
    <sec id="sec-14"/>
    <sec id="sec-15">
      <title>reference</title>
      <fig>
        <graphic mimetype="image" xlink:href="image3.gif"/>
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