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  <front>
    <article-meta>
      <title-group>
        <article-title>Exposure Index and Entrance Surface Dose of ANSI Chest Phantom with Computed Radiography</article-title>
      </title-group>
      <contrib-group content-type="author">
        <contrib contrib-type="person">
          <name>
            <given-names>Agung Nugroho Setiawan</given-names>
          </name>
          <email>agung.jtrr@poltekkes-smg.ac.id</email>
          <xref ref-type="aff" rid="aff-1"/>
        </contrib>
      </contrib-group>
      <aff id="aff-1">
        <institution>Program Studi Imaging Diagnostik, Magister Terapan Kesehatan, Poltekkes Kemenkes Semarang, Jawa Tengah, Indonesia</institution>
        <country>Indonesia</country>
      </aff>
      <history>
        <date date-type="received" iso-8601-date="2020-08-09">
          <day>09</day>
          <month>08</month>
          <year>2020</year>
        </date>
        <date data-type="published" iso-8601-date="2020-08-09">
          <day>09</day>
          <month>08</month>
          <year>2020</year>
        </date>
      </history>
    </article-meta>
  </front>
  <body>
    <fig>
      <graphic mimetype="image" mime-subtype="jpeg" xlink:href="image1.jpeg"/>
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    <p>
      <bold>www.ijamscr.com</bold>
    </p>
    <sec id="sec-1">
      <title>Exposure Index and Entrance Surface Dose of ANSI Chest Phantom with Computed Radiography</title>
      <sec id="sec-1_1">
        <title>Agung Nugroho Setiawan<sup>1*</sup>, Suryono<sup>2</sup>, Suharyo Hadisaputro<sup>1</sup>, A. Gunawan Santoso<sup>3</sup>, Bedjo Santoso<sup>1</sup>, Sugiyanto<sup>1</sup>, Gatot Murti Wibowo<sup>1</sup></title>
        <p>
          <italic>
            <sup>1</sup>
          </italic>
          <italic>Program </italic>
          <italic>Studi</italic>
          <italic> Imaging </italic>
          <italic>Diagnostik</italic>
          <italic>, Magister </italic>
          <italic>Terapan</italic>
          <italic>Kesehatan</italic>
          <italic>, </italic>
          <italic>Poltekkes</italic>
          <italic>Kemenkes</italic>
          <italic> Semarang</italic>
          <italic>, </italic>
        </p>
        <p>
          <italic>Jawa</italic>
          <italic> Tengah, Indonesia</italic>
        </p>
        <p>
          <italic>
            <sup>2</sup>
          </italic>
          <italic>Program </italic>
          <italic>Pascasarjana</italic>
          <italic>, </italic>
          <italic>Universitas</italic>
          <italic>Diponegoro</italic>
          <italic>, Semarang, </italic>
          <italic>Jawa</italic>
          <italic> Tengah, Indonesia</italic>
        </p>
        <p>
          <italic>
            <sup>3</sup>
          </italic>
          <italic>Rumah </italic>
          <italic>Sakit</italic>
          <italic> Dr. </italic>
          <italic>Kariadi</italic>
          <italic> Semarang, </italic>
          <italic>Jawa</italic>
          <italic> Tengah, Indonesia</italic>
        </p>
        <p><bold>*Corresponding Author</bold>: <bold>Agung</bold><bold>Nugroho</bold><bold>Setiawan</bold></p>
        <p>
          <bold>Email id: agung.jtrr@poltekkes-smg.ac.id</bold>
        </p>
        <sec id="sec-1_1_1"/>
        <sec id="sec-1_1_2">
          <title>ABSTRACT</title>
          <sec id="sec-1_1_2_1">
            <title>Background</title>
            <p>Radiographer shall ensure the radiation safety of the patient. Posteroanterior chest projection is a frequent examination in the radiology unit. Each radiographic projection must have a safe dose that justifies the dose reference level. One method for estimating the patient dose is using a patient equivalent phantom as an object of radiation exposure. The American National Standards Institute (ANSI) chest phantom was used to simulate chest radiographic examination. Computed Radiography is used for image receptor and provide the exposure index value.</p>
          </sec>
          <sec id="sec-1_1_2_2">
            <title>Objective</title>
            <p>The objective of this study is to describe the correlation between Exposure Index (EI) and Entrance Surface Dose (ESD) of ANSI chest phantom that mimicking the patient condition using Computed Radiography.</p>
          </sec>
          <sec id="sec-1_1_2_3">
            <title>Method</title>
            <p>Phantom was irradiated with an X-ray equipment using exposure factors for chest examinations. X-ray equipment, dosimeter, imaging plate and CR programs were well calibrated. EI on the Carestream CR system, as seen on the monitor. ESD measured with calculation method (indirect assessment of incident air kerma). The correlation between EI and ESD is obtained by statistical calculations.</p>
          </sec>
          <sec id="sec-1_1_2_4">
            <title>Result</title>
            <p>The result showed a positive, very strong and significant correlation between EI and ESD of ANSI chest phantom radiographic examination (r = 0.819 and p-value &lt;0.01). Under the controlled conditions used in this study, the EI values were stable.</p>
          </sec>
          <sec id="sec-1_1_2_5">
            <title>Conclusions</title>
            <p>Entrance Surface Dose can be estimated through Exposure Index value in this Carestream CR. EI can be used as a dose control mechanism on exposure with the same radiation object.</p>
            <p>Keywords: ANSI chest phantom, Entrance Surface Dose (ESD), Exposure Index (EI), Computed Radiography.</p>
          </sec>
        </sec>
        <sec id="sec-1_1_3"/>
        <sec id="sec-1_1_4">
          <title>Introduction</title>
          <p>Radiographer shall ensure the radiation safety of the patient, with a great care of radiation protection principles. The goal of radiation protection is to minimize the probability of stochastic risks and to prevent the occurrence of deterministic effects. To achieve this goal, the ICRP (2007) has developed a framework that is guided by the same three principles described in its 1991 recommendations. These principles relate to justification, optimization, and dose limitation [1]. While justification refers to the fact that every exposure a patient receives must have a positive net benefit associated with it, optimization is intended to ensure that all exposures be kept as low as reasonably achievable (ALARA) without compromising the diagnostic quality of the examination. Dose limits, on the other hand, are outlined in ICRP Publication 60 [2]. </p>
          <p>Each radiography examination should meet the value of the dose reference level, including chest radiography. This examination still remains the mainstay of chest imaging despite the known diagnostic superiority and increasing availability of cross-sectional techniques. The main advantages of chest radiographs are the speed at which they can be acquired and interpreted, the low cost and the low radiation exposure. Upright chest radiographs still play an important role as a fast tool to rule out various chest diseases and cardiac congestion or to monitor response to therapy. Portable radiographs are the main tools to monitor patients in intensive care units (ICU). Chest radiography is responsible for approximately 30– 40% of all X-ray examinations performed, regardless of the level of health-care delivery [3]. Chest radiography is the most common radiographic procedure performed in medical imaging departments, and one of the most often repeated exams. It is estimated that in the United States 68 million chest radiographs are performed each year. Chest radiography is performed to evaluate the lungs, heart and thoracic viscera [4]. </p>
          <p>Representation of the patient anatomy can be best characterized by anthropomorphic phantoms. The effects of exposure parameters and the results of the imagepost-processing techniques can be easily observed on the images. However, their higher cost puts some limitations on the wide range applications of these phantoms in the hospital environment. As for other types of the phantom used in the dosimetry, i.e. the patient equivalent phantom (PEP). Use of patient equivalent phantom intended to represent scattering and attenuation of tissue so it can be applied to the conditions of radiation exposure that is similar to the clinical examination. The high cost of procuring the phantom, becoming an obstacle for the hospital/clinics. Need to replace efficiency efforts that phantom with phantom types, such as the use of simple attenuator slabs or ANSI phantom [5].</p>
          <p>ANSI phantom can become an object of radiation exposure as one of the methods in the estimation of radiation dose patients. Researchers utilizing ANSI chest phantom, as a representation of the difference in attenuation and scattering, on chest radiographic examination using Computed Radiography (CR). The exposure factors were kV and mAs, commonly used for chest radiography that produce radiation dose profiles (Entrance Surface Dose), in accordance with the report of AAPM number 31 [6]. The reason for using Computed Radiography (CR) as the image receptor is to get accurate information related with Exposure Index on the use of CR, in particular, to know the relationship with patient dose. Another reason is the CR that widely used in Indonesia, thus optimizing the use of EI parameter, the radiographer will be helped in keeping the patient dose remains at the safe level.</p>
        </sec>
        <sec id="sec-1_1_5">
          <title>Method</title>
          <p>This research was conducted with x-ray exposure to ANSI chest phantom with some variation exposure factors (kV and mAs) to find out the value of the Entrance Surface Dose (ESD) and an Exposure Index (EI) on Computed Radiography. </p>
          <p>X-ray machine which used in this study (GE medical system, model E7843X) declared pass the compliance test, that required in Perka Bapeten, 2011 includes: a) kVp accuracy; b) timer accuracy; c) exposure linearity; and exposure reproducibility [7]. Carestream Directview Classic CR System under normal circumstances, and declared pass the accuracy of exposure indicators test, as well as in the report of AAPM's number 93 [8]. Patient equivalent phantom, created in accordance with the ANSI specification of chest phantom in the AAPM Report number 31 [9]. Dosimeter RaysafeX2 (serial number: 214331) is well calibrated.  </p>
          <fig>
            <graphic mimetype="image" mime-subtype="jpeg" xlink:href="image2.jpeg"/>
          </fig>
          <p>
            <bold>Figure 1.</bold>
            <bold> ANSI chest phantom according to AAPM report number 31</bold>
          </p>
          <p>The research samples were 45 (forty-five) ESD and EI values resulted from the 15 (fifteen) combination of exposure factors (kV and mAs) with ANSI chest phantom as radiation object. Radiation exposure performed on ranges of 50-110 kV, mAs 1-10 and completed as many as 3 times on every combination of kV-mAs. The resulted radiation exposure should meet the range of exposure as in the AAPM Report number 31.</p>
          <p>EI on the Carestream CR system, as seen on the monitor. The scheme of EI data collecting as in the figure below.</p>
          <fig>
            <graphic mimetype="image" mime-subtype="png" xlink:href="image3.png"/>
          </fig>
          <p>
            <bold>Figure 2.</bold>
            <bold> Geometric scheme of the EI ANSI chest phantom data collecting with CR</bold>
          </p>
          <p>Measurement of exposure radiation on ANSI chest phantom has been done with a scheme in figure 3.</p>
          <fig>
            <graphic mimetype="image" mime-subtype="png" xlink:href="image4.png"/>
          </fig>
          <p>
            <bold>Figure 3.</bold>
            <bold> Geometric scheme measurement of ESD on ANSI chest phantom use </bold>
            <bold>RaySafe</bold>
            <bold> dosimeter</bold>
          </p>
          <p>ESD measurement conducted with calculation method (indirect assessment of incident air kerma equation) as stated on IAEA Technical Report Series No. 457, on the following equation 1 and 2 [1]:</p>
          <p>K<sub>e</sub>=B. K.<sub>i</sub> (Eq. 1)</p>
          <p>(Eq. 2)</p>
          <p>Ke: ESD or entrance surface air kerma (mGy)</p>
          <p>B: backscatter factor</p>
          <p>: Incident air kerma (mGy)</p>
          <p>Y(d): The X-ray tube output measured at a distance (mGy/mAs) </p>
          <p>: Tube loading during the exposure of the patient (mAs)</p>
          <p>d: Distance from tube focus </p>
          <p>: The patient thickness</p>
          <p>: Focus to image receptor distance</p>
          <p>The analysis of the correlation between EI and ESD conducted with statistical analysis.</p>
        </sec>
        <sec id="sec-1_1_6">
          <title>Results</title>
          <p>The results showed that the range of ESD is 0,155 until 0,415 mGy. The range of EI is 2.001,33 until 2.733,33. When we plot it into the graph, showed that EI is directly proportional to the exposure; hence, a high exposure will result in a high EI, and a low exposure will generate a low EI.</p>
          <p>The resume of results shown in Table 1 and Figure 4 the following.</p>
          <p>
            <bold>Table 1.</bold>
            <bold> The results of the measurement ESD and EI on ANSI chest phantom</bold>
          </p>
          <table-wrap>
            <table>
              <tr>
                <td>
                  <bold>No.</bold>
                </td>
                <td>
                  <bold>kV</bold>
                </td>
                <td>
                  <bold>mAs</bold>
                </td>
                <td>
                  <bold>ESD (</bold>
                  <bold>mGy</bold>
                  <bold>)</bold>
                </td>
                <td>
                  <bold>
                    <italic>Exp. Index</italic>
                  </bold>
                  <bold> (EI)</bold>
                </td>
              </tr>
              <tr>
                <td>1</td>
                <td>60</td>
                <td>10</td>
                <td>0,219±0,000</td>
                <td>2096,67±12,70</td>
              </tr>
              <tr>
                <td>2</td>
                <td>60</td>
                <td>8</td>
                <td>0,172±0,001</td>
                <td>2001,33±8,96</td>
              </tr>
              <tr>
                <td>3</td>
                <td>70</td>
                <td>10</td>
                <td>0,311±0,001</td>
                <td>2389,00±3,00</td>
              </tr>
              <tr>
                <td>4</td>
                <td>70</td>
                <td>8</td>
                <td>0,244±0,000</td>
                <td>2290,00±4,00</td>
              </tr>
              <tr>
                <td>5</td>
                <td>70</td>
                <td>6,25</td>
                <td>0,193±0,000</td>
                <td>2193,33±5,51</td>
              </tr>
              <tr>
                <td>6</td>
                <td>80</td>
                <td>10</td>
                <td>0,415±0,002</td>
                <td>2613,67±7,57</td>
              </tr>
              <tr>
                <td>7</td>
                <td>80</td>
                <td>8</td>
                <td>0,326±0,002</td>
                <td>2517,33±7,64</td>
              </tr>
              <tr>
                <td>8</td>
                <td>80</td>
                <td>6,25</td>
                <td>0,256±0,001</td>
                <td>2414,00±2,00</td>
              </tr>
              <tr>
                <td>9</td>
                <td>80</td>
                <td>4</td>
                <td>0,162±0,000</td>
                <td>2210,33±8,32</td>
              </tr>
              <tr>
                <td>10</td>
                <td>90</td>
                <td>6,25</td>
                <td>0,330±0,003</td>
                <td>2582,33±2,31</td>
              </tr>
              <tr>
                <td>11</td>
                <td>90</td>
                <td>4</td>
                <td>0,209±0,002</td>
                <td>2389,00±2,00</td>
              </tr>
              <tr>
                <td>12</td>
                <td>100</td>
                <td>6,4</td>
                <td>0,411±0,001</td>
                <td>2733,33±2,89</td>
              </tr>
              <tr>
                <td>13</td>
                <td>100</td>
                <td>4</td>
                <td>0,257±0,000</td>
                <td>2534,00±3,00</td>
              </tr>
              <tr>
                <td>14</td>
                <td>110</td>
                <td>4</td>
                <td>0,311±0,000</td>
                <td>2650,33±6,02</td>
              </tr>
              <tr>
                <td>15</td>
                <td>110</td>
                <td>2</td>
                <td>0,155±0,000</td>
                <td>2344,67±8,39</td>
              </tr>
            </table>
          </table-wrap>
          <p>
            <bold>Figure 4.</bold>
            <bold> Correlation of Exposure Index and ESD</bold>
          </p>
          <p>Statistical analysis with Pearson correlation test found that Exposure Index and ESD have a linear relation as expected. Correlation has the r value = 0.819 and p-value &lt; 0.01, this means Exposure Index and ESD have a positive, very strong relationship and significant. Higher EI will increase ESD, vice versa.</p>
        </sec>
        <sec id="sec-1_1_7">
          <title>Discussion</title>
          <p>The dose to the patient is determined by the X-ray technique factors (kV, mAs, grid, SID, filtration, beam collimation), X-ray beam penetrability and quality, the amount of energy imparted to the body, and the size and area of the body irradiated. The exposure incident on the detector is determined by the remnant radiation (primary radiation transmitted through the patient and scattered radiation transmitted from the patient) that is absorbed, converted to electronic signals, and formatted into a digital radiographic image with a given detective quantum efficiency (DQE). The DQE is a measure of information transfer efficiency that is dependent not only on the efficient absorption of X-rays but also on the conversion into a useful signal with minimum corruption by other detector noise sources (such as electronic and artifact noise). The exposure index is a measure of the signal level produced by a digital detector for a given incident exposure transmitted through the patient, is proportional to the signal-to-noise ratio squared (SNR<sup>2</sup>), and is related to image quality [10]. </p>
          <p>Entrance Surface Dose in this study was obtained by the method of calculation, using the solid-state dosimeter to acquire tube output of x-rays, which are used to calculate the incident air kerma. ESD exposure on the phantom shows a value between 0.6-15, 77 (10-6 C/kg). Fifteen exposure factors that meet the AAPM Report Number 31 range, can be applied to be the parameter in chest radiography patients because it has a smaller value than the dose of Bapeten's guide (&lt; 0.4 mGy) [11].</p>
          <p>Carestream’s CR Exposure Index (EI) using the equation, EI = 1000. log (E) + 2000. E is an acceptable dose detector on imaging plate (mR). The image with the exact recommended exposure expected at the range of EI between 1700-2300 [12].</p>
          <p>This research obtained the EI range values on the phantom: 2001-2733. So, then we could say that only five exposure factors combination that approved with the manufacturer's recommendations, i.e. 60 kV-8 mAs, 60 kV-10 mAs, 70 kV-6,25 mAs, 70 kV-8 mAs and 80 kV-4 mAs. The ideal combination or chosen exposure factor for chest radiography study is a combination of the values that meet the ESD condition of Bapeten's guide and the EI value that fulfill manufacturer recommendation.</p>
          <fig>
            <graphic mimetype="image" mime-subtype="png" xlink:href="image5.png"/>
          </fig>
          <p>
            <bold>Figure 5.</bold>
            <bold> The ideal combination of exposure factors in this study</bold>
          </p>
          <p>Ideal exposure factor that resulted from this study, is 80 kV and 4 mAs. This value could be a parameter for evaluating the consistency of the EI value with a phantom object. The reason for using this value is because have a low dose (0,162 mGy), and EI=2.210 still on the accepted range of EI manufacturer recommendation (between 1,700-2,300).</p>
          <p>The result of this study shows the same conclusion with Warren-Forward, et al [9], Butler, et al [10] as well as the Silva and Yoshimura [11]. The research showed the very strong and significant correlation between EI and ESD. Under the controlled conditions used in this study, the EI values were stable. This means that the higher EI indicated the increasing ESD, or in another word, Entrance Surface Dose can be estimated through Exposure Index value in this Carestream CR system. </p>
          <p>But, ANSI phantom study has limitation due to their responses to beam quality, scatter and photon transmission. Furthermore, need a clinical adjustment with using anthropomorphic phantom for next study. </p>
        </sec>
        <sec id="sec-1_1_8">
          <title>Conclusion</title>
          <p>EI can be used as a dose control mechanism on exposure with the same radiation object. Radiographer can do the dose optimization with Exposure Index information from the CR system, to keep the lowest dose but in acceptable image quality range.</p>
          <sec id="sec-1_1_8_1">
            <title>Acknowledgment</title>
            <p>This article has been extracted from the M.App.Sc. Student thesis that was approved by the Examiner Board in <italic>Program </italic><italic>Studi</italic><italic> Imaging </italic><italic>Diagnostik</italic><italic>, Magister </italic><italic>Terapan</italic><italic>Kesehatan</italic><italic>, </italic><italic>Poltekkes</italic><italic>Kemenkes</italic><italic> Semarang</italic> dated 21<sup>st </sup>March 2017. We appreciate the sincere cooperation and assistance of those who helped us in the implementation of this research. Special appreciation and thanks to <italic>Badan</italic><italic>Pengembangan</italic><italic>dan</italic><italic>Pemberdayaan</italic><italic>Sumber</italic><italic>Daya</italic><italic>Manusia</italic><italic>Kesehatan</italic><italic>Kementerian</italic><italic>Kesehatan</italic><italic> RI,</italic> with student scholarship which mandated to us.</p>
          </sec>
        </sec>
        <sec id="sec-1_1_9">
          <title>References </title>
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