Articles

  1. Method development and validation of dabigatran in pharmaceutical dosage form by RP- HPLC method Download Article

    Ajitha A, P.Sandhya Rani, Chandu
    • Article Type: Research Article
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    • Pages (01-08)
    • No of Download = 93

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    A simple precise, accurate method was developed and validated by reversed phase high performance liquid chromatography method used for the estimation of Dabigatran in bulk and pharmaceutical dosage form. It is reversed phase liquid chromatography. The HPLC method has been carried out by using C18 150x4.6mm 5µm column. This method has been developed by using the mobile phase consisting buffer: Acetonitrile 65:35 and the flow rate of 1ml/min by the detection of UV at 330nm. The retention time of the dabigatran is 0.999 min. The runtime is 15min. the linearity was found to be over a concentration of 25%-150% respectively. The accuracy was found to be 98.84 to 100.24%. With a correlation coefficient of0.999.The proposed method can be used for the estimation of the drug in bulk and pharmaceutical formulation. The results of analysis have been validated satisfactorily using recovery studies.

  2. RP-HPLC method development and validation for estimation of doxorubicin and in bulk and pharmaceutical dosage form Download Article

    Monika Renikunta, Dr.T.Rama Mohan Reddy, Dr.Konde Abbulu
    • Article Type: Research Article
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    • Pages (09-16)
    • No of Download = 91

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    A simple, Precised, Accurate method was developed for the estimation of doxorubicin by RP-HPLC technique. Chromatographic conditions used are stationary phase Discovery C18 150mm x 4.6 mm, 5 ,Mobile phase 0.1% OPA: Acetonitrile in the ratio of 45:55 and flow rate was maintained at 0.9ml/min, detection wave length was 234 nm, column temperature was set to 30oC and diluent was mobile phase Conditions were finalized as optimized method. System suitability parameters were studied by injecting the standard six times and results were well under the acceptance criteria. Linearity study was carried out between 25% to150 % levels, R2 value was found to be as 0.999. Precision was found to be 0.6 for repeatability and 0.7 for intermediate precision. LOD and LOQ are 0.085µg/ml and 0.258µg/ml respectively. By using above method assay of marketed formulation was carried out 99.90% was present. Degradation studies of doxorubicin were done, in all conditions purity threshold was more than purity angle and within the acceptable range.

  3. Spectrophotometric method development and validation for the estimation of ticagrelor in bulk and its dosage forms Download Article

    P. Sireesha, A. Ajitha, T. Rama Mohan Reddy
    • Article Type: Research Article
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    • Pages (17-20)
    • No of Download = 74

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    Simple, sensitive, accurate, precise, stability indicating UV spectrophotometric method have been developed for quantitative determination of ticagrelor in bulk and its dosage form. The UV spectrum was scanned between 200-400 nm and 254 nm was selected as maximum wavelength for absorption. Beer’s law was obeyed in the concentration range of 2-10µg/ml were found the method was successfully applied to the pharmaceutical dosage forms containing the above mentioned drug without any interference by excipients. Results of the analysis were validated as per ICH guidelines. This method can be used for the routine and quality control analysis of ticagrelor in raw material and pharmaceutical formulations.

  4. Analysis of the Effect of Phantom CT Scan Diameter Variations on Radiation Dose with IndoseCT Download Article

    Intan Andriani, Wahyu Setia Budi, Heri Sutanto, and Choirul Anam
    • Article Type: Research Article
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    • Pages (21-27)
    • No of Download = 85

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    The dose received by a patient who performs a CT scan is influenced by several factors, namely slice thickness, pitch, position and size of the patient, range of scanning and type of scanning. The amount of radiation dose received from the scan also depends on phantom geometry, form and material. The method of calculating a patient's dose on a CT scan is known as the Computed Tomography Dose Index (CTDI). According to research that has already been carried out, it is explained that CTDI represents only the surface dose of the body. SSDE is then used to calculate the central dose of phantom and phantom edge. The purpose of this study was to determine the dosage size for variations in phantom diameter and SSDE values with the IndoseCT program for variations in phantom diameter. The measurement method in this study was carried out using a piranha detector and IndoseCT software. The results of the study found that there were differences in the values of CTDIc, CTDIw, and CTDIvol, each having a range of 0.93% to 147.96%, 26.65% to 62.48%, 11.51% to 41.46%. SSDE values for phantom size 8 cm, 16 cm, 24 cm, 32 cm and 40 cm respectively are as follows: 29 mGy, 23.09 mGy, 16.86 mGy, 12.35 mGy, 9.27 mGy. The conclusion of this study is that the greater the effective diameter of phantom the smaller the SSDE.

  5. Effectiveness of nutritive balls for weight gain among preschool children at selected school Download Article

    Kavitha.P
    • Article Type: Research Article
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    • Pages (28-31)
    • No of Download = 69

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    A study was done to assess the effectiveness of nutritive balls for weight gain among preschool children at selected School, Perambalur. Quasi experimental design was adopted for the study. 30 samples were selected from School through convenient sampling technique & divided into experimental and control group. The demographic data were collected from the preschool children. Weighing machine were used to assess the level of weight gain in preschool children. Significant difference was found between pretest and posttest levels of weight among preschool children in experimental group at <0.001 level. The comparison between experimental group and control group posttest shows that the intervention is effective. There was no significant association between the posttest value of weight and their selected demographic variable.

  6. Analysis on the use of packaged pineapple juice as an alternative for oral negative contrast medium in magnetic resonance enterography (MRE) Download Article

    Ni Putu Rita Jeniyanthi, Sugiyanto, A. Gunawan Santoso, Made Wijaya, Choirul Anwar
    • Article Type: Research Article
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    • Pages (32-39)
    • No of Download = 75

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    Background Oral negative contrast medium used for Abdominal examination made of chemicals has some negative effects on the body and some are difficult to find in the market and are expensive too. Thus, the solution is to conduct a study to find alternative oral negative media in abdominal MRI examination by using fruit ingredients such as, blueberry juice, pineapple juice and tea that contain lots of manganese (Mn) [1] Objective This study by using natural alternative oral negative contrast medium in MRE that is considered to be ready in Indonesia, the taste is acceptable and not cause a negative effect after its use [2, 3] Methods This study was an experimental study with Pretest-Posttest Control Group Design. Data analysis was performed with One Way Anova Test and Repeated Anova with Tukey’s Post Hoc test. Results There was a difference on the digestive system diameter before and after the administration of packaged pineapple juice as an alternative oral negative contrast medium in MRE examination with p value < 0.05 Conclusion p value was 0.043 and the optimal scanning time in MRE image was 20 minutes after the administration of packaged pineapple juice based on the highest Mean Rank with the value of (20.16). Recommendation Packaged pineapple juice with high manganese content can be an alternative oral negative contrast medium in MRE examination with optimal scanning time at 20 minutes after the administration.

  7. The shrimp rebon as alternative for increasing hemoglobin levels in anemia pregnant Download Article

    Nurul Asrofah, Supriyana, Mardiyono
    • Article Type: Research Article
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    • Pages (40-45)
    • No of Download = 48

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    Background Anemia in pregnancy is one of the national problems because it reflects the value of socio-economic well-being of the community and its influence is very large on the quality of human resources. Increased iron status can also be done with various approaches, namely pharmacological and non-pharmacological. The main source of iron is animal foods including rebon shrimp. Rebon shrimp as a source of iron is needed in the formation of hemoglobin levels. Method The type of research used was research True Experimental with a pretest-posttest control group design. This study compiled two groups, namely the intervention group and the control group. Technique Probability sampling with method was simple random sampling used to get 34 respondents divided into 2 groups. Results The results of the test Mann Withney show values p value of 0,000 so that there are differences in hemoglobin levels in the intervention and control groups. Conclusion The results of the study after being given an intervention that rebon shrimp are effective as an alternative to increasing hemoglobin levels in anemic pregnant women.

  8. Clinical note on use of povidone iodine in periodontics Download Article

    Dr. Vasundhara Bhaskar Rikame, Dr. Yogesh S. Doshi, Dr. Robert A. Horowitz, Dr. Mona U. Shah, Dr. Cauvery N. Karbhari, Dr. Talat Mohammadi, Dr. Nikita Jain.
    • Article Type: Research Article
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    • Pages (46-52)
    • No of Download = 55

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    Povidone iodine (PVP-iodine) is one of the widely used antiseptics in the field of medicine and surgery but it has not gained significant attention in dentistry. It is one of the most potent antiseptics with a wide range of antimicrobial action and high safety profile. It is effective against periodontal pathogenic bacteria, viruses and fungi. In vitro studies have demonstrated the toxic effects of PVP-I on fibroblasts. A question exists whether to use povidone iodine as an irrigating agent in periodontal surgery. The aim of this review is to describe the potential benefits of PVP-I in periodontal infections and periimplantitis, and its possible adverse effects. This article will provide clinical notes for the use of PVP-I in dentistry, concentration to be used and precautions to be taken while using it intraorally on open wounds.

  9. Combination of oxytocin massage and dried dates on the amount of postpartum hemorrhage and involution uterine in normal postpartum Download Article

    Sri Wahyuni, Ariawan Soejoenoes and Runjati
    • Article Type: Research Article
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    • Pages (53-56)
    • No of Download = 48

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    Background The range incidence of postpartum hemorrhage from 5% - 15%, and 40%-50% is caused by a lack of adequate contractions. Oxytocin Massage can stimulate the release of oxytocin which plays an important role in uterine contractions after labor, while dried dates contain potassium as a neurotransmitter that affects of the uterine muscles and calcium which helps the blood clotting process. Objective Proving the combination of oxytocin massage and consumption of dried dates is more effective against the amount of postpartum hemorrhage andinvolution uterine in normal postpartum. Method Quasy experimental with posttest only design. Respondents were who gave birth in September 2018 as many as 45 respondents. Divided into 3 groups, the first group is the oxytocin massage intervention, the second group is the dried datesfruit intervention and the third group is the combination intervention. The statistical test used by Friedman, Kruskal Wallis and Chi-Square. Results The amount of postpartum hemorrhage at2 hours postpartum p> 0.05.While 6 hours and 12 hours postpartum p< 0.05. The combination group showed the lowest average of 23 ml. While involution uterine at 6 hours postpartum p> 0.05 while on day 3 and on day 6 postpartump<0.05. The combination group showed the lowest average of 3.94 cm. The combination of oxytocin massage and dried date fruit is more effective against postpartum hemorrhage and involution uterine. Conclusions and Recommendations In additional midwifery service, the use of oxytocin massage and consumption of dried dates is highly recommended to amount of postpartum hemorrhage and involution uterine.

  10. Potential Combination of Cinnamon Type C. Burmanii with C. Cassia as an Antibacterial Alternative in Perineal Wound Infection (Laboratory Study of S. Haemolyticus Culture of Perineum Wounds) Download Article

    Citra Adityarini Safitri, Rasipin, Supriyana
    • Article Type: Research Article
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    • Pages (57-60)
    • No of Download = 39

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    Background Use and misuse of antibiotics in puerperal infections can trigger the emergence of resistant bacteria. To overcome antibiotic resistance, tannin compounds, flavonoids and alkaloids in cinnamon serve as a safe antibacterial with fewer side effects. Objective Proving the combination of C. Burmanii with C. cassia as an antibacterial alternative to perineal wound infection. Methods Laboratory experiments in vitro. The study group was divided into 2 groups, namely the treatment group concentrations of 1.25%, 2.5%, 5% and 10%, the control group used Amoxicillin 500 mg. Data analysis using ANOVA test was then with Tukey HSD test. Results ANOVA test results were obtained 0.00 in the bacterium S. haemolyticus. p-value = 0.000 (<0.05) where antibacterial in cinnamon shows a significant difference in the zone of the killing of S.haemolyticus bacteria in perineal wound infection. Conclusions and Recommendations Tannin compounds, flavonoids and alkaloids in a combination of cinnamon are effective as an antibacterial alternative to perineum wound infections. clinical trial research is needed with experimental animal research subjects with a toxicity test to ensure that the extract is safe to use in experimental animals.

  11. Hematological manifestations of Tuberculosis – a review Download Article

    Amrita Bhattacharya, Anita Tahlan, Mitesh Kumar
    • Article Type: Review Article
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    • Pages (61-65)
    • No of Download = 55

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    Background Tuberculosis is a major public health problem in India. There is a paucity of literature in the hematological changes associated with tuberculosis, though tuberculosis is a common condition. Objective: To evaluate the hematological parameters in tuberculosis and find its assertiveness as a diagnostic, prognostic and predictive tool for physicians. Conclusion Variety of hematological abnormalities has been demonstrated in patients with tuberculosis in the present review. Many of them are consistent with reported literature and reinforce the fact that they can be valuable tools in monitoring tuberculosis such as anemia and increased ESR. Other findings such as thrombocytosis and pancytopenia suggest the need for further studies in this field.

  12. The use of basil leaf materials to perineal wound healing in post partum mothers (case study in the work area of muna district health service) Download Article

    Sitti Sarti, Ari Suwondo, Mardiyono
    • Article Type: Research Article
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    • Pages (66-70)
    • No of Download = 37

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    Background Maternal events that have perineal rupture in Indonesia in the age group 25-30 years are 24%, and at the age of 32-39 years are 62%. The incidence of perineal rupture is high, from a total of 1951 vaginal births, 57% experienced perineal rupture. The impact of the occurrence of perineal rupture is infection. One preventive effort is to reduce the incidence of infection in postpartum mothers by treating vulva. While Povidon Iodine used has side effects caused by irritation, toxic reactions from Iodine will cause irritation. The use of Iodine could change skin pigmentation into dark red. Herbal medicines commonly used in the society are plants that produce secondary metabolites. One of the plants that has flavonoids is basil leaves. Objective To analyze the effect of basil leaf extract spray as an antiseptic on the postpartum maternal perineal wound healing process. Methods Quasi Experiment with pre and post test design group control design. Accurate design time with the control group (control time series design), the inspection is carried out for 7 days. The total sample of 34 people was divided into 2 groups (17 control groups and 17 intervention groups). Results The results of the analysis of spraying basil leaf extract on REEDA healing perineal wounds had a significant difference obtained p value = 0,000. Conclusions and Recommendations The administration of basil leaf extract spray affects to the healing of post partum maternal perineal wounds. It is expected that further research can examine the factors that can influence the process of perineal wound healing.

  13. Combination of consumption of musa balbisiana colla and herbal mask of varian rice on breast against breast milk production of post partum mothers in Demak district Download Article

    Dwi Sulistiyowati, Mardiyono, Imam Djamaluddin Mashoedi
    • Article Type: Research Article
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    • Pages (71-80)
    • No of Download = 40

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    Background The process of giving breast milk or breastfeeding is the best way to provide ideal food for baby's growth and development. The provision of exclusive breast milk in reality for six months is not as simple as imagined. Many obstacles arise in an effort to provide exclusive breast milk for the first six months of a baby's life. Not all mothers want to breastfeed their babies for various reasons. For example, fear of being fat, busy, saggy breasts and so on. On the other hand, there are also mothers who want to breastfeed their babies but the mother's milk does not want to go out or the production is not smooth Research methods This type of research is True Experimental Design with the design of the Pretest-Posttest Control Group Design. The affordable population in this study was postpartum mothers who carried out exclusive breastfeeding in the working area of the puskesmas kebonagung regency demak in July-August 2018. A sample of 51 people. Research result The results showed that the combination of musa balbisiana colla consumption and rice variant herbal mask for breast was effective against the production of breast milk in postpartum mothers with indicators of infant weight, frequency of breastfeeding babies, frequency of infant urination, infant sleep duration Conclusion The results of this study can be seen that the intervention given is a combination of consumption of musa balbisiana colla and rice variant herbal mask for breast effective against breast milk production in postpartum mothers

  14. Potential of date palm fruit (Phoenix Dactylifera) for improving haemoglobin and ferritin level in anemic female adolescent Download Article

    Dewi Triloka Wulandari, Runjati and Ari Suwondo
    • Article Type: Research Article
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    • Pages (81-84)
    • No of Download = 45

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    Background Anemia is one of the health problems throughout the world, especially in developing countries, which is estimated to be 30% of the world's population suffering anemia. Management of anemia is by consuming Fe tablets, but Fe tablets have side effects, namely defecation and nausea. One alternative to prevent anemia is using dates palm fruit that are rich in iron and also contain protein, fiber, glucose, vitamins, biotin, niacin, and folic acid. Date palm fruit contains complete nutrients with no side effects when given in patients with anemia. Objective To prove the program of improving hemoglobin and Ferritin levels by using Dates Palm fruit (Phoenix Dactylifera) in 14 days of female adolescent conducted in the intervention group and the control group. Method True experiment: with pretestposttest control group design. The dependent variable is the hemoglobin and ferritin level, the independent variable is dates palm fruit. The female adolescent research subjects as many as 30 respondents were divided into 15 intervention groups given Fe and Dates palm fruit and 15 control groups were only given Fe tablets. Treatment was done for 14 days. Blood measurement uses laboratory analysis. Results Dates palm fruit can increase hemoglobin levels significantly (Mean ± SD 11.76 ± 0.69 p value 0.041), while Ferritin levels did not change significantly (Mean ± SD 38.61 ± with a p value of 0.057). Conclusions and Suggestions Date Palm fruit has a lot of nutritional content used to increase hemoglobin and ferritin levels. Date palm fruit has the potential as an alternative treatment for anemia.

  15. Potential of seed leaves (psidii folium) extracts as alternative materials on changes in hemoglobin and ferritin levels in youth teenage (Case study in bakhti nusantara vocational school) Download Article

    Angela Ditauli Lubis, Supriyana, Runjati
    • Article Type: Research Article
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    • Pages (85-90)
    • No of Download = 45

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    Background Anemia is a health problem throughout the world, especially in developing countries. The incidence of anemia in adolescent girls is 57.1%. Management of anemia was carried out by administering Fe tablets, but Fe tablets had side effects, namely defecation and nausea, which led to reduced compliance with drug consumption. One alternative to preventing anemia is to use guava leaf extract which can reduce nausea side effects and contain antioxidants for the body and blood profile levels. Objective To prove the influence of guava leaf extract on changes in hemoglobin levels and ferritin levels Research Methods: The type of research method used is True Experiment. The research design used was pretest and post-test control group design. With a sample of 30 female adolescents divided into 2 groups, namely the control group given Fe 60 mg and the intervention group gave Fe 60 mg and guava leaf extract 500 mg. Data analysis using Wilcoxon and Independent T-Test Results After the intervention was given p-value = 0.027 (<0.005) means that there were differences in hemoglobin values after being given treatment in both groups. The mean mean ferritin of the treatment group> Control group (24.33 ng / dl> 10.48 ng / dl), p-value = 0,000 (<0.005) means that there are differences in ferritin values after treatment in both groups. Conclusion Guava leaf extract has an effect on increasing hemoglobin levels and ferritin levels. Suggestion. Guava leaf extract can be used as an alternative therapy for increased hemoglobin and ferritin levels

  16. Potential of Tahongai leaf extracts (Kleinhovia Hospital.) in handling vaginal discharge caused candida albicans: laboratory study Download Article

    Ni WayanEti Parwati, Supriyana, and Masrifan Djamil
    • Article Type: Research Article
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    • Pages (91-95)
    • No of Download = 39

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    Background Candida Albicans is the main causative pathogenic microorganism with a recurrence rate of 40-45% causing disruption of the female reproductive organs and conventional discomfort and treatment causing various side effects and resistance. For this reason, it is necessary to conduct research to prove herbal ingredients as a potential alternative treatment in cases of pathological vaginal discharge that are expected to contribute to midwifery services. Objective To aim the potential of effective extracts of tahongai leaves able to inhibit candida albicans in vitro, as well as the duration of the inhibitory power of more than 24 hours. Method True experimental post-test only control group design, subjects used candida albicans isolates from vaginal patients with the Mc Farland standard suspension 0.5. The inhibitory test uses the disk diffusion method using Fluconazole control. Results There are influences of inhibition of various concentrations namely 0.39%, 0.78%, 1.56%, 3.125%, 6.25%, 12.5%, 25%, 50%, 75%, 100% of candida albicans with ANOVA statistical tests (p_value<0.05 ) The post-hoc test results showed that the concentration of effective extract was 100% with Fluconazole having a inhibition power not different or the same as the p value = 0.999 (> 0.05) because the average strength of the delay was not far adrift. The old ability of extract inhibition also exceeds 24 hours, which is 48 hours with 72 hours indicating the same inhibition power than before. So, the future opportunity to use tahongai leaf extract clinically can be used once a day for vaginal discharge. Conclusions and Recommendations The effective 100% concentration of tahongai leaf extract has the potential as an alternative ingredient for vaginal discharge caused by albicans candida. next study preclinical test Potential of tahongai leaf extract Tahongai leaf extract (Kleinhoviahospita L.) to the inhibition of candida albicans with experimental animal subjects. So that the results of research can be applied to humans as an alternative treatment for vaginal discharge in providing midwifery care to reproductive health services for women of childbearing age.

  17. Determination of spatial resolution using TC99M on Spect with distance detector variations Download Article

    Nofrita Angelina Metungku
    • Article Type: Research Article
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    • Pages (96-99)
    • No of Download = 31

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    It is very important to pay attention to the spatial resolution of the SPECT tool regularly every week to ensure the SPECT plane works optimally so that it can produce more accurate image quality. Using the MATLAB program can help to determine the FWHM value and spatial resolution. In the MATLAB program to calculate the value of FWHM using the ESF and PSF methods, the FWHM values obtained the value of spatial resolution. In this research, several detector distances are used to obtain the best spatial resolution values. the spatial resolution obtained is 0.01 lp/mm-0.04 lp/mm with different distances. The most optimum value is obtained at a distance of 20cm from the detector with a spatial resolution value of 0.04 lp/mm. Quality Control of spatial resolution of images through FWHM calculations can be calculated using the ESF and PSF methods in the Matlab program.

  18. To study the cardiac autonomic functions in leprosy patients, a hospital based study- an original research article Download Article

    Dr. Usha Kataria, Dr. Mukesh Kumar, Dr. Jeewandeep Kaur
    • Article Type: Research Article
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    • Pages (100-105)
    • No of Download = 38

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    Aims and Objectives The aim of this study was to evaluate cardiac autonomic functions in leprosy patients and to compare the same between paucibacillary, multibacillary leprosy patients and with the normal healthy subjects. Materials and Methods We studied twenty five paucibacillary, twenty five multibacillary leprosy patients and twenty five age matched healthy subjects. Non invasive bedside tests i.e. orthostatic test, Valsalva ratio, hand grip test, effect of deep breathing and standing were studied in all subjects. Results Both sympathetic and parasympathetic functions were altered in both the leprosy groups when compared to normal subjects. On intergroup comparison we observed that the paucibacillary group had higher values then the multibacillary leprosy group. Conclusion To comment regarding the alteration in cardiac autonomic function, this was a very small study group, we need larger study group to reach the proper conclusion.

  19. Solitary bone plasmacytoma in young age Download Article

    Banupriya M, Jagadeesan M, Ranjan Kumar Mahapotra, Parthiban B, Prasanna Karthik S
    • Article Type: Case Report
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    • Pages (106-109)
    • No of Download = 39

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    Plasmacytoma is a rare localized plasma cell tumor. SBP are found primarily in axial skeleton, particularly the vertebrae, ribs, and pelvis, but may involve any bone in the body. Plasmocytoma involving the clavicle is very rare. We report a 18 year old female who presented with swelling and pain at the lateral end of left clavicle, diagnosed as solitary plasmacytoma of clavicle.

  20. Baby massage theraphy in improving breastfeeding production and bounding attachment between mom and baby in primipara postpartum mother Download Article

    Sholikhah, Noor Pramono and Ari Suwondo
    • Article Type: Research Article
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    • Pages (110-118)
    • No of Download = 35

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    Background Research on infant massage on breast milk production and Bounding Attachment was carried out because there were still many primipara postpartum mothers whose breast milk was not fluent, therefore the researcher took a study on infant massage on breast milk production and bounding attachment in the work area of Mojogedang II health center. Massage is a tactile stimulation that has biochemical and physiological effects in the baby, increase infant weight, and stimulate milk production. Purpose To prove whether baby massage can increase milk production and Bounding Attachment in primipara postpartum mothers. Method This research type is Quasi Experiment with Purposive sampling. Test analysis used is General Linier Model Repeted Measure Anova. Results The average increase in breast milk infant massage intervention was 24,34 ml while the control group was 2,67 ml. The average increase in infant massage infant weight gain was 0,13 grams while in the control group was 0,06 grams. The average increase in bounding attachment for the infant massage intervention group was 5,13 while in the control group was 0. The p value is > 0,05. Conclusion From the results of the study stated that there was a difference in the average increase in milk production, infant weight and bounding attachment between treatment and control groups, namely in the treatment greater than the control group, the value of p > 0.05 means the hypothesis was not accepted.

  21. A Case Report on Friedreich’s Ataxia Download Article

    Ragesh. G, Karthik.S, P. Seenivasan
    • Article Type: Case Report
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    • Pages (119-122)
    • No of Download = 39

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    Friedreich’s ataxia is a genetic disorder that causes certain nerve cells to weaken over time. Gene mutation at 9q13 and 9p23-p11. GAA trinucleotide repeats expansion of intron 1 from 70 to more than 1000 GAA triplets, and uncontrollable decreased vitamin E levels. Friedreich’s ataxia also affects the heart, bones and pancreas cells that produce insulin. Loss of coordination, fatigue, vision impairment, aggressive scoliosis, DM and serious heart condition (cardiomyopathy) are the major signs and symptoms. This is a case review presenting: A 25-year-old male patient admitted in a general medicine with the chief complaints of breathlessness and pedal edema since 10 days and he was previously treated for upper respiratory tract infection. The patient was swaying to the right associated with curvature of the spine. These symptoms progressed slowly and then noticed to have difficulty in lifting both upper and lower limbs simultaneously in both proximal and distal regions. Difficulty in turning in bed, deterioration of vision since last three years, presently only able to appreciate light. He was found to have high sugar level since last year. Past medical history reveals that known case of DM and dilated cardiomyopathy since one year. Based on the patient medical history, physical examination, neurologic examination, neuroimaging, three-generation family history, and molecular genetic testing the patient complaints were diagnosed as friedreich’s ataxia. Patient initially managed with symptomatically followed by physical therapy. Antioxidant such as vitamin E, coenzyme q10 and idebenone were given to delay the disease progression. Medications to lower the blood sugar, heart disease (ACE inhibitor) prescribed to reduce the co-morbidities with Friedrich’s ataxia. Surgery is preferred to correct bony deformities. The patient improved after 17 days of therapy. Patient discharged on request and advised to go for eye check-up. Regular physiotherapy and speech therapy recommended improving their cognitive functions.

  22. Ointment Extract banana stem (Musa balbisiana) As An Alternative Healing Wounds perineum (laboratory test on rat) Download Article

    Pramita Putri Utami, Bedjo Santoso, and Runjati
    • Article Type: Research Article
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    • Pages (123-126)
    • No of Download = 47

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    Background Approximately 85% of women who have vaginal spontaneous birth experience perineal trauma, 52% are spontaneous lacerations. Sap of banana trees have several benefits because banana stem sap contains compounds including saponin, tannin, anthraquinone, quinone, lectin, and gallic acid. Objective To determine the effectiveness of extract oinment sap of stem banana (Musa balbisiana) as an alternative to healing perineal wounds Method True experiment with posttest only control group design, sampling using method Simple random sampling. The number of samples for each group was 6 with the total number of samples 18. Analysis of the data using the Friedman Test and continued with Kruskall Wallys. Results The Kruskal Wallis test results showed the average perineal wound healing in the intervention group was 0.00, while the povidone iodine 1.20 group and 0.80 dry wash group, p value = 0.011 (<0.05) which means the intervention group stem banana ointment, povidone iodine and dry washing method have significant differences in perineal wound healing. Conclusions and Recommendations extract ointment sap of stem banana effective for alternative to healing perineal wounds. It is necessary to develop ointment extract sap of stem banana in the form of a more practical container, which is a tube to avoid exposure to other substances when used.

  23. Reactor Study of Double Dielectric Barrier Discharge (DDBD) Plasma for Ozonation Olive Oil Download Article

    Puryadi, Muhammad Nur, Sumariyah, Maryam Resti Wijaya, and Jhon Bosco Niyomukiza
    • Article Type: Research Article
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    • Pages (127-131)
    • No of Download = 42

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    Ozone gas is a gas consisting of three oxygen molecules and is a disinfecting agent. Olive oil is oozed using ozone gas generated by a Double Dielectric Barrier Discharge (DDBD) plasma reactor. DDBD reactors are generated with a voltage of 3.75 kV at a frequency of 50 Hz and a Duty Cycle (DC) of 30% at various oxygen gas flow rates 0.1, 0.3 and 0.6 L / minute. The parameters measured were dissolved ozone concentrations and dissolved ozone doses in olive oil. The results showed that the dissolved ozone concentration in olive oil was inversely proportional to the oxygen gas flow rate, while the dissolved ozone dose was directly proportional to the oxygen gas flow rate. At the flow rate of 0.1, 0.3 and 0.6 L / min of the concentration of dissolved ozone were 2398.8, 1672.4 and 1077.9 ppm, and the dissolved ozone doses were 1101.3, 2293.9 and 2964.8 mg O3/g of oil respectively.

  24. The potential of herbal steam bath and acupressure at SP 6 and LI4 acupoints in blood pressure normal postpartum mother (stimulating physicalrecovery) Download Article

    Alfika Awatiszahro,Suryati Kumorowulan and Supriyana
    • Article Type: Research Article
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    • Pages (132-135)
    • No of Download = 38

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    Background All normal postpartum mothers will experience physical changes due to the process of pregnancy and childbirth that require stimulation to restore their health. One change that occurs is blood. The body of the postpartum mother tends to be cold due to blood loss during the birth process causing the mother to tend to be easily sick. Herbal steam bath and acupressure as a non-pharmacological therapy to help restore the health of postpartum mothers through the principle of warming to the blood through increasing changes in blood pressure as an indicator of increasing body metabolism Objective To determine the potential of steam bath and acupressure herbs for recovery of postpartum maternal health through changes in increased systolic and diastolic blood pressure Method Quasi Experiment with pre-post control group design, sampling using accidental sampling method. Respondents were 51 people divided into 3 groups, 17 respondents were given steambath herbal treatment, 17 respondents were given acupressure treatment and 17 respondents were controls. Data analysis using Krusskal Wallis Test and continued with Mannwhitney PostHoc. Results Herbal steam bath increased systolic blood pressure 5.8 mmHg and diastolic blood pressure 3.4 mmHg. Acupressure lowers systolic blood pressure 1 mmHg and diastole blood pressure 0.5 mmHg. The manhitney test obtained a p value of <0.05, meaning that there was a significant difference in herbal steam bath to help increase the postpartum blood pressure compared to acupressure and control. Conclusions and Recommendations Giving herbal steam bath therapy stimulates the health of postpartum mothers and increases the body's metabolism characterized by increasing blood pressure. Herbal steam baths can be used as nopharmacological treatments to help restore the health of postpartummothers.

  25. Endocrowns: when less is more Download Article

    Dr. Ashwini Dessai, Dr. Neeta Shetty, Dr. Kundabala M.
    • Article Type: Case Report
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    • Pages (136-140)
    • No of Download = 37

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    The need for replacement of crown in a grossly decayed endodontically treated tooth is a challenging task for most practitioners. Post and cores are the most widely recommended treatment option for such cases associated with extensive loss of tooth structure, which is eventually followed by fabrication of full coverage crowns supported by metal or adhesively bonded cores. In the past, it was believed that this procedure would help in reinforcing the remaining tooth structure.However, it is now evident that a post would only serve as a mechanical retainer for the core and does not strengthen the compromised tooth.Ideally, a post-endodontic restoration should protect and preserve the existing tooth structure, while restoring esthetics, form, and function. The aim is to achieve a minimally invasive preparation with maximum tissue conservation for restoring endodontically treated teeth. With the advent of adhesive dentistry it is now possible to limit the amount of tooth preparation required. The endocrown was first proposed by Bindl and Mormann, who suggested that it would produce a monblock effect by utilising the available surface in the pulp chamber and obtain retention through adhesive bonding.This case report highlights the successful post endodontic management of an extensively decayed molar using a ceramic endocrown

  26. The effect of cork fish extracts (channa striata) on changes in immunoglobulin g levels in childbirth mother can’t eats source of animal protein (Study in Work Area UPT Wanareja I Health Center, Cilacap Regency) Download Article

    Nunung Tri Susilowati, Ari suwondo, Diyah Fatmasari
    • Article Type: Research Article
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    • Pages (141-146)
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    Background Infection is still one of the causes of maternal death, the recovery process of the puerperium is related to the involution and healing process of the birth canal. Cork fish extract can be used as an alternative source of protein food for postpartum mothers who undergo abstinence from consuming animal protein sources. This study aims to determine the effect of cork fish extract (chana striata) on changes in immunoglobulin G levels in postpartum women who never eat animal protein sources. Subjects and Methods The research design is quasy experiment with the pretest posttest one group design. This research was conducted in the work area of the UPT of Wanareaja I Community Health Center, Cilacap Regency, from May to July 2018. The population of all postpartum mothers. Sampling technique with purposive sampling. The number of samples 30 was divided into 2 groups, 15 postpartum women as the control group who were only given Fe tablets and 15 postpartum mothers as the treatment group who received cork fish extract at a dose of 700mg / day 1x1 for 10 days. Independent variable influence of cork fish extract, dependent variable immunoglobulin level G. Instrument for immunoglobulin G examination using ELLISA method. Hypothesis testing using independent t test. Results There was a significant difference between the treatment group and the control group 2.44±2.065, 1.126±1.445 p value 0.050 Conclusion Giving capsules of cork fish extract dose 700 mg / day 1x1 for 10 days had an effect on immunoglobulin G of postpartum mothers.

  27. Kawista fruit (limonia acidissima) extract as an alternative reduction of vomiting in pregnancy (study of laboratory in mice) Download Article

    Nurul Hidayati,Suryati Kumorowulan and Supriyana
    • Article Type: Research Article
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    • Pages (147-151)
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    Background Nausea and vomiting are common symptoms in pregnancy and occur in 50-90% of pregnant women. Although mice are unable to vomit they display a gaping reaction when their serotonin levels increase. Serotonin levels in non-pregnant mice approach the lower detection threshold (0.004pmol / islet). And it increases 200 times during pregnancy. High serotonin levels can cause nausea. Vitamine B6 is believed to be a safe and effective drug to reduce nausea and vomiting in pregnancy. Kawista fruit extract has a high vitamine B6 content. Side effects on vitamine B6 drugs are severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling in the mouth, face, lips, or tongue); decreased sense of touch, temperature, or vibration; loss of balance; numbness in the legs or around the mouth; numbness or tingling in the skin. Objective The aim of the study was to prove the effect of kawista fruit extract to reduce the frequency of nausea in mice. Method This study is a quantitative study that uses an experimental design model with one-group pre-test and post-test design. The number of samples used was 20 muskulus mice which were divided into 4 groups, 5 controls, 5 POR, 5 kawista 0.5mg and 5 kawista 1.0mg. The examination was carried out for 6 days including gaping / gaping reflexes in mice. The sampling technique was random sampling with regard to inclusion criteria. Data analysis using Kruskal Wallis statistical test followed by Post Hoc. Results The results of this study showed a decrease in nausea and vomiting before and after intervention, the average number of gaping on day 4 in the kawista fruit treatment group was 1.0 mg, 6 times or 62% per day and value 0,000 (<α = 0, 05), the average number of gaping in the kawista fruit extract treatment group dose of 0.5 mg is 7 times or 66% per day and p value 0,000 and while the POR group has an average value of nausea vomiting 8 times per day or 84% and p value 0.008. Conclusions and suggestions It can be concluded that there is an effect of consumption of kawista fruit extract to reduce nausea in mice. Based on the results of these studies it is suggested to be able to apply the use of kawista fruit especially in maternal health services.

  28. Brain image analysis by using support vector machine (svm) method Download Article

    Lilis Suliani, Kusworo Adi and Catur Edi Widodo
    • Article Type: Research Article
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    • Pages (152-155)
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    Research on image analysis of the brain with Support Vector Machine method had been carried out through image processing using matlab software. The CT Scan image data was entered using the “imread” command then pre-processing was performed to eliminate noise with the mean method (multiplication operation between matrix components). After the pre-processing, image histogram analysis was carried out to find out the distribution of pixel intesity values on the image. The final step was calculating the mean and standard deviations specified with all pixel value calculation on every brain image. Value calculation the mean and standar deviation were carried out to 7 normal images and 7 brain tumor images. Mean and standar deviation calculation were used as a parameter to determine normal class and brain tumor class with SVM classification. The calculation results of he normal images have mean values with the range from 65.45 until 88.50 and standard deviation values with the range from 44.41 until 49.50, where as the brain tumor images have mean values with range from 69.46 until 93.29 and standard deviation values with range from 50.05 until 61.60. Therefore, the results of this study show that the mean and standar deviation of brain tumor images is greater than the normal images.

  29. Bird eye view of homoeopathic research: past, present and future Download Article

    Dr. Sudhir M Juvekar , Dr. Govind D Girase
    • Article Type: Research Article
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    • Pages (156-162)
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    In era of target specific drug discovery, Homoeopathy is struggling to construct quality evidence and expedient research method. Multiple outcomes are being studied with potential benefits in Homoeopathic treatments. Single subject trial is an important research area aims to identify individual disease susceptibility. Autonomic Nervous System (ANS) selective remedy response proves law of simplex [1]. Doctrine of drug dynamisation is addressed by identifying Nano particles in Homoeopathic high potency dilution [2]. Nature maintains and regulates ANS activity, Homoeopathic natural principle need to be validated on scientific instruments [3,4]. Homeostasis is regulated by ANS; remedy relationship will give new dimension to Homoeopathy

  30. The De Ritis (AST/ALT) ratio in alcohol dependence syndrome with and without alcoholic liver disease Download Article

    Dev Shanker Yadav M.Sc., Dr. Johnson Pradeep MD, Dr.Vinod G. thykadavil l3 P.hD.
    • Article Type: Research Article
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    • Pages (163-169)
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    Introduction Alcoholism is characterized by an impaired control over drinking, preoccupation with alcohol and use of alcohol despite adverse consequences. Alcohol consumption is associated with a number of changes in cell functions and the oxidant-antioxidant system. Aim and objectives The main aim of the study is to estimate the Serum AST, Serum ALT, De Ritis ratio (AST/ALT ratio) and GGT in ADS with and without alcoholic liver disease patients. Material and methods It was a cross-sectional study performed in alcoholic patients in inpatients of the department of Psychiatry, at St. John’s Medical College and Hospital. The total sample size was 60, out of which 30 were ADS subjects with alcoholic liver disease and 30 were ADS subjects without liver disease. The parameters including AST, ALT, GGT and BMI were performed on each groups and then compared statistically by Mann Whitney U test. Laboratory parameters were also correlated with alcohol related clinical variables. Result The analysis revealed a significantly elevated AST, AST/ALT ratio and GGT in ADS with ALD group than without ALD group; however there was no significant difference in ALT between both the groups. Conclusion This study has highlighted the importance of not only the individual markers such as AST or ALT but also the ratio of them. In the future, a combination of markers should be use to improve the specificity and sensitivity of these markers in identifying early damage of liver in Alcoholism. This will help in prevention of alcoholic cirrhosis which is the end stage of liver damage

  31. Periodontal disease and pre-term low birth weight: A systematic review article Download Article

    Dr. Harneet Singh Mago, Dr. Surangama Debnath, Dr.Shekhar Prashant, Dr.Jagriti Basu, Dr.Jagriti Basu
    • Article Type: Review Article
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    • Pages (170-174)
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    Introduction Periodontal diseases are common among world population. Systemic conditions often are influenced by periodontal diseases. Recently there have been many studies that have associated periodontal diseases with adverse pregnancy outcomes. The various adverse outcomes include pregnancy gingivitis, preterm low birth weight, preeclempsia etc. Out of these preterm low birth weight poses a major threat to community health. PTLBW remains an alarming concern for health care providers. Aim The goal of this paper is to review the literature regarding periodontal diseases and pre-term low birth weight, and provide oral health care providers with resources to educate their patients. Search design The present literature review was based on findings extracted from online search of PMC indexed journals, Google scholar, MEDLINE and CINAHL databases from the year 2000 onwards. Inclusion criteria Only case-control studies written and published in English language were included. Study subjects with mean age from 15-45 years met the inclusion criteria. Exclusion Criteria Any case control study reported earlier to 2000 were excluded. Reports in languages other than English were excluded from the review. The search keywords were pregnancy gingivitis, periodontal disease, low birth weight, oral health, and preterm delivery. Results Of 300 articles, 10 studies with a total of 5358 participants with a mean age ranged from 15 to 45 years were met the inclusion criteria. The studies focused on preterm birth, low birth weight and /or preterm low birth weight and periodontitis. The findings from the selected case control studies were summarised in a tabulated form. Conclusion Periodontal disease is a high risk factor for preterm low birth weight babies. However, more precise studies with randomized clinical trial with long term follow-up period must be carried out to affirm the relationship between periodontitis and pre term low birth weight.

  32. Application "senyum gigiku" android based media promotion as prevention caries dental knowledge and attitudes toward increasing the mother mother in district banyudono PKK Download Article

    Aditya Nurrochman, Masrifan Djamil, and Bedjo Santoso, Lanny Sunarjo, Rasipin
    • Article Type: Research Article
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    • Pages (175-183)
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    Aditya Nurrochman Applications "SENYUM GIGIKU" as the android-based caries prevention media campaigns to improve the knowledge and attitude of the PKK in the District Banyudono Background Dental caries is one of the problems of the oral cavity which can cause pain and interfere with the activity and reduce the quality of life of patients. Dental caries prevention can be done by improving the knowledge of individuals with dental health education (DHE). The success of dental health education can not be separated from the methods and media used. Application of Augmented Reality is currently under development in the world of education. Aim Establishment of Application "SENYUM GIGIKU" As Android-Based Dental Caries Prevention Media Campaign Against Increasing Knowledge and Attitudes Mothers PKK Method Quasy experiment with pre-test post-test non-equivalent control group design. 24 research subjects in the intervention group and 24 in the control group. Variables examined knowledge and attitudes. The analysis is, Friedman test, Man Whitney, Repeat Measure Anova, Independent T-test, Manova. Result Test the feasibility of application "SENYUM GIGIKU" prosentast results obtained with 85.2% (Good) and material aspects of the due diligence with a percentage of 87% (Good). On the measurement of knowledge using the application "SENYUM GIGIKU" gained a significant difference with p value = 0.000, while the provision of attitude formation Applications "SENYUM GIGIKU" there is a significant difference with p value = 0.000. On the measurement of the use of Application "SENYUM GIGIKU" with the use of methods of demonstration using props, there is a significant difference with p value = 0.000. Conclusion It has been composed Applications "SENYUM GIGIKU" android-based and can effectively improve the knowledge and attitude of the PKK in the prevention of cavities. Use of Applications "SENYUM GIGIKU" is more effective than konvensonal health promotion.

  33. Effect of mat and swiss ball based pilates exercises in students with chronic non specific low back pain Download Article

    Sahil Ghorpade, Keerthi Rao
    • Article Type: Research Article
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    • Pages (184-195)
    • No of Download = 12

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    Background Non-Specific Low Back Pain is a major health problem worldwide. Interventions based on exercises have been the most commonly used treatments for students with this condition. Over the past few years, the Pilates method has been one of the most popular exercise programmes used in clinical practice. Objective To compare the effectiveness of Mat and Swiss Ball Based Pilates Exercise on functional disability in terms of Modified Oswestry Disability Index (MODI) and Endurance in terms of Ito Test in Students with Chronic Non Specific Low Back Pain (CNSLBP). Methodology 40 participants between the age of 18 to 25 years with the clinical diagnosis of CNSLBP were selected. Participants were randomly divided into Group (A), which received Mat Pilates exercise and Group (B) received Swiss Ball Pilates exercise for 4 weeks of duration under the guidance of therapist. Pre and post intervention assessments were done. Result There was a significant difference seen on comparison between the individuals pre and post interventional statistics of both Groups, nevertheless, when comparison was made between the Post results, there was a significant difference in Group A as compared to Group B. Conclusion The current study concluded that Mat based Pilates exercises showed more improvement in both the variables.

  34. To assess effect of smoking on cerebral blood flow Download Article

    Akanksha Sisodia, Dr. Sanjeet Singh, Dr. Mukesh Kumar
    • Article Type: Research Article
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    • Pages (196-200)
    • No of Download = 16

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    Background Smoking is known to interfere with NO mediated endothelial function therefore impairing the cerebrovascular blood flow (CBF).Cigarette smokers also have raised fibrinogen levels and platelet count which makes the blood stickier. All these factors make smokers more vulnerable to cerebrovascular diseases. Purpose of the Study The purpose of the present study was to determine whether the level of cigarette use is a significant predictor CBF when age, gender, is controlled. The objective of the study was to assess and compare cerebral blood flow in smokers and non- smokers and to correlate the alterations in cerebral blood flow with the no. of cigarettes and duration of smoking. Methods The subjects consisted of 50 smokers and 50 non-smokers without any history of respiratory disease, cardiac disease or any other chronic disease. Smoking index was calculated and Mean cerebral blood flow (CBF) in Anterior (ACA), Middle (MCA) & Posterior (PCA) cerebral arteries were measured by the Trans-cranial Doppler method (TCD) method. Results Subjects had an average smoking index of (number of cigarette smoked per day) x year of smoking history) 450 +_ 164. CBF was measured using trans-cranial Doppler method. Simple linear regression analysis demonstrated a negative correlation of smoking index with CBF in all the major cerebral arteries (LMCA, r = -0.119), (RMCA, r = -0.34), (LACA, r = -0.36),( RACA, r = -0.34),(LPCA, r = -0.33) and (RPCA, r= .000).

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