Articles

  1. Added effect of fascia taping technique on pain and foot function in patients with plantarfasciitis Download Article

    Binjal Solanki, Dr. Anjali Kulkarni (PT), Dr. Snehal Ghodey (PT)
    • Article Type: Research Article
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    • Pages (310-315)
    • No of Download = 72

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    The purpose of this study is to investigate the added effect of fascia taping technique on pain and foot function in patients with plantarfasciitis using VAS and FFI scores respectively. Plantarfasciitis has become one of the common chronic overuse injury of the plantar fascia of foot, most commonly at its insertion affecting 10% of the population amongst the total non-traumatic foot injury.26 (men and women) subjects with plantarfasciitis were recruited for the study and equally divided into two groups. The patients in the control group were given traditional physiotherapy (plantarflexor stretching, plantarfascia stretching and icepack for 10-15mins) on first day and patients in the experimental group were given fascia taping technique in addition to the traditional physiotherapy. Tape was applied on the plantarfascia for continuously 3 days. Pre and post assessment was carried out on first day and third day of treatment. VAS and FFI are the outcome measures used the study to asses pain and foot function. Wilcoxon matched-pairs signed-ranks Test was used to analyse the pre and post values of VAS and FFI in control and experimental group with results as extremely significant with p-values as 0.0005 and 0.0002 respectively for FFI scores. VAS scores shows very significant (0.002) results in control group and extremely significant (0.0005) in experimental group. Mann-Whitney U Test was used to analyze the difference of mean of control and experimental group i.e. extremely significant (0.0002) for FFI and significant (0.016) for VAS. Fascia taping technique is effective in treating pain and improving foot function in patients with plantarfasciitis.

  2. Added effect of mitchell relaxation technique with analgesics in reducing pain during functional activities in women after caesarean section Download Article

    Komal Patel, Dr.Snehal Chincholkar(PT), Dr.Anuradha Sutar(PT), Dr.Snehal Ghodey(PT)
    • Article Type: Research Article
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    • Pages (316-322)
    • No of Download = 50

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    The purpose of the study is to determine the added effect of Mitchell relaxation with analgesics in reducing pain during functional activities after caesarean section. Women after caesarean section experience pain due to operative trauma in bed mobility, sit-stand, walking till few days. Pain management can be done pharmacological and non pharmacological. The Mitchell Relaxation technique is non pharmacological management for pain reduction. This was an experimental study with pre and post test design, randomly assign, two group study was conducted in BSTRH..Post caesarean section primigravida women who met inclusion criteria were assigned to either experimental (n=30) or control group (n=30). Women in the experimental group received Mitchell relaxation technique with analgesics and those in the control group were managed only with analgesic. The outcome measure was a patient specific functional scale in which bed mobility, sit-stand, walking where they painful functional activities. Pre values were taken prior to medication on 2nd post partum day and post values were taken on 4th post partum day after 2 hours of medications. Statistical analysis was done and the difference between the pre and post values of the experimental group was more significant than the control group.The study shows that added effect of Mitchell relaxation with analgesics is more efficient in the reduction of pain during functional activities in women after caesarean section.

  3. Bipolar disorder, symptoms and its marketed drugs-a review Download Article

    A.Madhusudhan Reddy, P.Srinivasababu, Y. Sai Tejaswi, I.V.Sainadh, S.Sai Madhuri, V. Sowmya, V.Sowmya, T.Joseph
    • Article Type: Review Article
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    • Pages (323-329)
    • No of Download = 43

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    Bipolar disorder is an illness of the brain that causes severe cycles in a person’s frame of mind (mood), energy level, thinking and activities. According to the criteria defined in Diagnostic and statistical manual DSM-IV-TR, people with Type I bipolar disorder will experience at least one episode of mania that may include mixed, depressive and hypomanic episode. Similarly for type II bipolar disorder patients may experience only hypomanic and depressive episodes. But for Cyclothymic disorder they may be diagnosed by having not experiencing any manic, mixed and depressive episodes. They only experience numerous periods of both depressive and hypomanic symptoms for minimum of 2 year or with symptom free period. [3] There are 4 types of bipolar diorders, bipolarI, II, cyclothymia, and bipolar disorder not specified. There is no single known cause for bipolar disorder as many provoking factors act together to produce the bipolar disorder illness. The symptoms that are seen in bipolar disorder are remarkable and erratic mood changes. The illness may have two strongly contrasting phases: mania and depression.

  4. Post Term Extrauterine Abdominal Pregnancy, a case report Download Article

    Abrehet Gebrekidan
    • Article Type: Case Report
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    • Pages (330-334)
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    Introduction When implantation of the fertilized ovum occurs anywhere outside of the uterine cavity it is called ectopic pregnancy. Abdominal pregnancy is a rare type of ectopic pregnancy where the developing embryo implants and grows within the peritoneal cavity. Abdominal pregnancy is classified as being primary and secondary. Most abdominal (ectopic) pregnancies are secondary from aborted or ruptured tubal pregnancy. Extrauterine abdominal pregnancy is missed during antenatal period even with the use of ultrasound. Case history A 39 years old woman gravida VI, para V with history of severe supra pubic pain at 10 weeks of amenorrhea which was treated with Antipain and bed rest presented to the maternity hospital. During ante natal follow up abnormal fetal malpresentation and easily fetal parts were palpated. Diagnosis was missed during ante natal period. The eminent signs were client’s history and flat abdomen x-ray which revealed the fetal demise. At first client was managed conservatively including induction of labor with oxytocin which failed. Later surgical intervention (Laparotomy) was performed and a dead fetus was extracted from the abdominal cavity. Umbilical cord was cut at its insertion to the placenta leaving the placenta in situ for its natural autolysis. On inspection intra-operatively the uterus, the left fallopian tube and both ovaries were intact and normal while the right fallopian tube was not identifiable. Post operative period and later follow up of the mother was awesome. Conclusion Diagnosis of abdominal pregnancy is missed during antenatal care despite the use of modern diagnostic tools like Ultrasonography, Magnetic resonance imaging etc as in many cases the exact location of the fetus and its size are not ascertained. High index of suspicion is needed to make first diagnosis of abdominal pregnancy. This case report is presented to draw attention to obstetrics and/or midwifery care providers the challenges related to diagnosis and its management to prevent life threatening complications in poorly resourced centers.

  5. A study to assess neonatal outcomes followed by caesarean section at Orotta National Referral Maternity Hospital, Asmara, Eritrea Download Article

    Dr. P. Kavitha, Simret Ghebremedhin BSc NM, ZaidTeame BSc NM, HirityMobatsion BSc NM
    • Article Type: Research Article
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    • Pages (335-341)
    • No of Download = 34

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    Out of the estemated130 million infants born each year worldwide, 4 million die in the first 28 days of life.3/4 of neonatal deaths occur in the first week and more than ¼ occur in the first 24 hours. Neonatal deaths account for 40%of deaths under the age of 5years worldwide. An institutional based Prospective cross sectional descriptive study was used to asses neonatal outcome of mothers delivered by C/S. 115 mothers were selected using convenience sampling technique from November 9, to December 9, 2013. Data were collected using structured questionnaires. Result Out of 115 samples common indications for C/S were 19.1% fetal distress and 19.1% previous C/S. out of 119 births 18(15-5 %) had Apgar score of <7 in one minuet and after five minutes14 improved, 4 were<7 and 4 (3.4%) were still birth. Out of 115 live births 14 (11.8%) were admitted to NICU and 2(1.7) were died within 7 days, but one died before admission. Conclusion It is evident that fetal distress, previous C/S, prolonged labor, mal presentation, changes in FHR, Emergency C/s, decision to incision time, incision to delivery time and type of anesthesia were the factors which affect the neonatal outcome.

  6. Added effect of strain counter-strain technique on pain & Cervical ROM in students with mechanical neck pain with upper trapezius trigger points. A RCT Download Article

    Krutika S. Panchal, Dr. Ravinder Kaur, Dr. Snehal Ghodey
    • Article Type: Research Article
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    • Pages (342-348)
    • No of Download = 48

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    Objectives To assess the added effect of Strain Counter-strain (SCS) technique along with conventional treatment on pain & cervical ROM in students with mechanical neck pain with upper trapezius trigger points. Methods In this experimental study, forty students with mechanical neck-pain & upper trapezius trigger points were randomly allocated into two groups, control or experimental group. The control group received conventional therapy consist of moist heat, supervised exercises and trapezius stretching and experimental group received Strain Counter-strain technique along with conventional therapy. Treatment was given once a day for 5 days. A numerical rating scale (NRS) was used to measure the intensity of pain, functional disability was assessed using NDI i.e. neck disability index, and cervical ROM was measured with universal goniometer. Data analysis was done on 5th day. Results On pre post analysis, NRS, NDI scores and cervical ROM showed a statistically significant improvement in both control and experimental groups (p < 0.0001). However, between group analysis both NRS and NDI scores showed statistically significant improvement in the experimental group (p < 0.0001). The range of motion for cervical flexion (p = 0.3184) and extension (p = 0.3126) was equally improved in both the groups. But, lateral flexion and rotation on both sides were statistically significantly improved in experimental group than in control group (p<0.0001). Conclusion Strain counter strain technique along with conventional treatment is effective in relieving pain & improving cervical lateral flexion and rotation ROM in students with mechanical neck pain with upper trapezius trigger points.

  7. Adverse drug reaction study in tertiary care hospital Download Article

    Avanthika Sidda, K.Chandralekha, Dr. Shivkumar Kashinath Shete
    • Article Type: Research Article
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    • Pages (349-361)
    • No of Download = 44

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    The prospective and observational non-interventional study was conducted in Aware Global Hospital. In-patients treated with drugs in the various clinical departments of hospital were reviewed on daily basis. All suspected ADRs will be suitably assessed for causality, severity, preventability and predictability. The results were presented as number and percentage. Among the 1129 cases (males and females), a total of 139 ADRs were detected, an overall incidence of 46.64% adverse drug reactions in inpatients. The prevalence of ADR mostly occurred in the age group between 31-60 years (46%) and in female patients (56.83%). The most frequent adverse drug reaction were due to Antibiotics (46%), Anti-Tubercular drugs (5.75%), Oral-Hypoglycemics (5.04%), NSAIDs (5.03%). Adverse drug reactions were a common occurrence and awareness about them was found to be essential for early detection and prevention. The healthcare system can promote the spontaneous reporting of ADR to Pharmacovigilance centre's for ensuring safe drug use and patient care. Our study suggests that there is a need of intensive ADR monitoring in tertiary care hospital for early detection and prevention to ensure the patient safety.

  8. Added effect of cyriax deep friction massage on functional ability in patients with chronic plantar fasciitis Download Article

    Nupura Taskar, Dr.Ravinder Kaur, Dr.Snehal Ghodey
    • Article Type: Research Article
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    • Pages (362-367)
    • No of Download = 46

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    Objectives To assess the added effect of Cyriax deep friction massage along with conventional treatment on functional ability in patients with chronic plantar fasciitis. Methods In this experimental study, 26 subjects with chronic plantar fasciitis were randomly allocated into two groups; control and experimental group. The control group received conventional therapy consists of ultrasound, tendoachilis stretching, plantar fascia stretching and intrinsic muscle strengthening. Experimental group received Cyriax deep friction massage along with conventional therapy. Treatment was given thrice a week for 2 weeks alternatively. Foot Function Index (FFI) Scale was used to assess the functional ability. Data analysis was done pre and post treatment. Result On pre post analysis, FFI score showed significant improvement in both control (P=0.0002) as well as experimental (P=0.0002) group. However between group analysis FFI showed significant improvement in experimental group (P<0.0001, U=8.000) Conclusion Cyriax deep friction massage along with conventional therapy was more effective in improving functional ability in patients with chronic plantar fasciitis.

  9. Study on Anti anxiety activity of ALERT – A Poly herbal formulation in Experimental animal models Download Article

    Veeresh Babu D, Ramesh Kulkarni, Jerin George
    • Article Type: Research Article
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    • Pages (368-378)
    • No of Download = 55

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    The present study was performed to evaluate the anti anxiety activity of ALERT – a Poly herbal formulation in experimental animal model. Anti anxiety activity was determined in experimental Swiss Albino Mice. The test was carried out by Elevated plus maze, Light/dark exploration test, Open field tests, Rota-rod test and Hole board test. In the Elevated Plus maze the total number of arm entries and the time spent in open and enclosed arms were recorded. In Light and dark exploration tests, the total number of arm entries and the time spent in light and dark chambers were recorded. In Open field tests the number Ambulation, Rearing, Self grooming, activity in center were recorded. In Hole board test the number and duration of head-dippings were recorded. In Rota-rod tests, the loco motor activity with fall in time was recorded. The animals were treated with three doses of the Poly herbal formulation ALERT, of doses low (50mg/kg), moderate (150mg/kg) and high (200mg/kg). In Elevated Plus maze significant increase in the number of entries and duration of stay in open arm was observed. In Light/ Dark exploration tests, significant increase in the time spent and numbers of entries in light compartment were observed. In Open field tests, there was significant increase in the number of squares crossed, number of crossings and rearing. In hole board tests, has shown a significant reduction in locomotion. In Rota- rod tests, significantly decreased time spent on revolving Rota-rod. The study revealed that the Poly herbal formulation ALERT possess significant anti-anxiety effect.

  10. MTA Apexification: A case report Download Article

    Dr Neha Joshi Tambake, Dr Sumit Tambake, Dr Deepak Metha, Dr Sayyed Mohammed Qadri, Dr Rohit Tambake, Dr Sejal Shinde Tambake
    • Article Type: Case Report
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    • Pages (379-383)
    • No of Download = 44

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    Introduction Apexification is the procedure to induce a calcified barrier in a root with open apex. Objective To describe the case of one step apexification using Mineral Trioxide Aggregate. Case report A 19 years old male patient was referred to private dental clinic. The patient’s medical history was noncontributory. On intraoral examination it showed discolored maxillary right central incisior with sinus tract formation and maxillary left central incisior tender when percussed. History of trauma was given approximately 10 years back. Radiographic examination showed fractured maxillary right central incisor with evident pulp exposure showing blunder buss apices and widening of periodontal ligament was seen related to maxillary left central incisor suggestive of apical periodontitis and tooth was tender to percussion. One step Apexification was done for bluderbuss apices of maxillary right central incisor and routine endodontic procedure was performed with maxillary left central incisor. Conclusion The present case describes one step MTA apexification related to maxillary right central incisor having blunderbuss apices and endodontic procedure related to maxillary left central incisor. Keywords: Mineral Trioxide Aggregate, Calcium hydroxide, Double Antibiotic Paste. (DAP)Triple antibiotic paste (TAP)

  11. Controlled release matrix drug delivery system – a review Download Article

    A.Madhusudhan Reddy, R.Karthikeyan, Ramya Sri.Vejandla, G.Divya, P.Srinivasa Babu
    • Article Type: Review Article
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    • Pages (384-398)
    • No of Download = 39

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    Oral controlled release drug delivery system becomes a very promising approach for those drugs that are given orally but having the high dosing frequency and shorter half life. Matrix tablets serves as an important tool for oral controlled release dosage forms. Problems like patient compliance drug targeting, local side effects, frequent administration and fluctuations in blood concentration levels, associated with their counter parts, the conventional dosage forms were rectified. Tablets offer the lowest cost approach to controlled and sustained release dosage forms. Matrix tablets controlled release has given a new breakthrough for novel drug delivery system in the field of pharmaceutical technology. This review focus on the various types of matrix system based on polymer used and porosity of matrix system i.e hydrophilic, hydrophobic, fat wax, porous, nonporous, pH sensitive. An effort has been made to consolidate different types of patents granted across the globe for last thirty years in the field of matrix system viz. tablets, pellets etc

  12. Effects of high and low intensity exercise training on body fat in young individuals- Comparative study Download Article

    Dhwani Sanghavi, Dr. Anuradha Sutar (PT), Aastha Lambah, Dr. Snehal Ghodey (PT)
    • Article Type: Research Article
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    • Pages (399-403)
    • No of Download = 36

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    The purpose of the study is to compare between the high intensity interval training (HIIT) and low intensity steady state (LISS) training for reduction of body fat % in young individuals. Since there are a lot of complications of increased fat in the body, it is necessary to find a protocol for fitness. A sample size of 42 was taken and 2 groups were made of 21 each using chit method. Subjects in LISS underwent a 40mins low intensity workout at RPE 11-12 for 5 times a week including aerobics, jog, and brisk walk. At the same time HIIT subjects had to undergo a protocol of 20mins at RPE 17-18 including 4 cycles of 1min work and 1min rest (step up and down, burpees, push-ups, butt kicks, sumo squats) 3 times a week. Data was recorded post the protocol of 5 weeks. An intraclass analysis showed statistically significant difference in pre and post values of both the groups (p values>0.001), whereas the interclass comparison between both the groups showed significant difference with HIIT having a significantly better result. Thus it was concluded that both the groups helped in fat reduction but HIIT had better and efficient results for fat reduction in young individuals. Also it is time efficient.

  13. Effect of PNF integration pattern on lower limb to improve limits of stability in geriatric population Download Article

    Aishwarya Ranbhor, Dr. Sayli Paldhikar (PT), Dr. Snehal Ghodey (PT)
    • Article Type: Research Article
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    • Pages (404-408)
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    The purpose of the study was to determine the effect of Lower Limb PNF integration pattern on Limits of Stability in geriatric population, as there are lesser studies done which improve the limits of stability using inexpensive and easy techniques. Method: A total of 38 subjects both males and females in the age group of 65 years and above, with less reach in forward, backward, right and left lateral components of Multi-directional Reach test were included while those with impaired vision, recent musculoskeletal conditions and neurological conditions were excluded. Assessment was done according to the MDRT before and after the complete treatment of 4 weeks. The treatment session included warm up exercises, followed by D1 Flexion-Extension and D2 Flexion-Extension patterns of PNF techniques, and cool down exercises including Shavasana. Results: On statistical analysis, a significant improvement in all four components of Multi-directional Reach test was found. Conclusion: PNF integration pattern are effective and can be used in improving Limits of Stability in geriatric population.

  14. Herpes zoster and multiple sclerosis: case study and short review Download Article

    Kannan R, Prasanna Karthik S, Jagadeesan M, Mahendrakumar K, Matthew J M Ng
    • Article Type: Case Report
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    • Pages (409-413)
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    A 37 year old man developed typical varicella zoster virus (VZV) infection affecting the left clavicular area (C4 dermatome). Subsequently, he experienced numbness over the left scapula, arm, and palm. This improved gradually over one and half months. Two months later, he had numbness affecting the right thigh. MRI showed ovoid lesions in the corpus callosum and hyperintense signal in the cervical cord area. Based on the clinical features of presence of CNS lesions that were disseminated in time and space with no better explanation for the disease process, multiple sclerosis (MS) was diagnosed. The patient was treated with oral azathioprine, gabapentin and amitryptyline and patient improved symptomatically . A brief literature review was conducted on the etiological link between VZV infection and MS, early diagnosis, and early treatment of MS. The ultrastructural finding of viral particles identical to VZV, together with the simultaneous presence of large quantities of DNA from VZV in the CSF, almost restricted to the periods of exacerbation, as well as its steady diminution and eventual disappearance from clinical relapse to clinical remission constitute the strongest evidence to date to support the participation of VZV in the pathogenesis of MS. Suppression of relapsing phases of the disease with immuno-modulatory treatment is the present day management consensus.

  15. The effect of neural tissue mobilization on cylindrical grip strength in old adults Download Article

    Nisha N. Ranade, Dr. Snehal Ghodey
    • Article Type: Research Article
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    • Pages (414-421)
    • No of Download = 37

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    Background & Purpose of the Study: Neural tissue mobilization has been reported to be an effective intervention for conditions like carpal tunnel syndrome though benefits are still under research. The effect of nervous tissue mobilization on various hand functions is not studied. Also, no interventions have been made for increasing the grip strength in old healthy adults within 40-60 years of age. Hence, this study. Methodology: A total of 100 subjects, both males and females with at least a single positive neural tissue tension test were included in the study whereas those with previous history of any neurological & musculoskeletal pathology were excluded from study. Subjects were evaluated for baseline data, grip strength measurements were taken before and after the mobilization using the Hydraulic Hand Dynamometer. Neural tissue mobilization was given for nerves with positive tension tests. Results: On data analysis, an increase was seen in the cylindrical grip strength after mobilization in both, males and females with affected neural tissue tension. With only median nerve involvement, there was a significant increase in the grip than that with ulnar and radial nerve involvement. Conclusion: Neural Tissue Mobilization techniques can be used for improving the grip strength in old adults.

  16. Oral health assessment among allied health science students –A cross sectional study Download Article

    Mayank Kumar Parakh, Nisha Ashifa, Jagannath G, Prabhu Subramani
    • Article Type: Research Article
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    • Pages (422-425)
    • No of Download = 78

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    Aims and background There is overwhelming evidence that periodontal disease and dental caries affect the majority of population’s especially young adults. Hence this study was taken to assess the oral health status of allied health science students using case history and oral indexes. Methodology In the study a total of 134 allied health science student’s oral health was assessed using a detailed case history followed by, Decayed Missing Filled Teeth (DMFT) index, Oral Hygiene Index-Simplified (OHI-S) and Angles classification were assessed. Results Total of 134 allied health science students were included in study of which 84 (62.68%) were females and 50 (37.31%) were male. The mean DMFT index was 5.58. Males had higher DMFT index than females and this difference was statistically significant. ( P value- 0.046) Discussion Our study showed that almost all students brushed twice daily -91.76% probably as oral health education is given to all students entering allied health science stream at our university. Conclusion There should be more awareness sessions conducted so that they realize how important oral health is to their overall health.

  17. A review on adverse drug reactions of antidiabetic drugs Download Article

    Trupti Ghatage, Ravindra Jarag, Sagar Jadhav, Rutuja Raut
    • Article Type: Review Article
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    • Pages (426-433)
    • No of Download = 54

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    India had 69.2 million people living with diabetes (8.7%) as per the 2015 data by WHO. of these, it remained undiagnosed in more than 36 million people. Effective management of diabetes and an adverse effect of drugs is associated with lower morbidity, mortality, and health care. Over time, high blood sugar can seriously compromise every major organ system in the body, causing heart attacks, strokes, nerve damage, kidney failure, blindness, impotence and infections that can lead to amputations. Treatment for diabetes includes insulin and oral antidiabetic agents. Along with these drugs, diabetic patients generally take medications to treat dyslipidemia, an antihypertensive drug, and antiplatelet therapy. Adverse drug reaction associated with antidiabetic treatment are hypoglycemia, hypoglycemic coma, hypersensitivity, hepatotoxicity, drug induced erythema multiforme, photodermatitis etc. So, it is need of the new era to aware people about the adverse effects of an antidiabetic drug. It is necessary to educate the patient on their medications and potential adverse events associated with each medication to limit potential treatment complications. The main objective of the article is to increase awareness about the drugs used in diabetes treatment, its consequences, and adverse drug reaction reporting.

  18. Formulation design and in-vitro evaluation of simvastatin pulsatile drug delivery system Download Article

    Srikanth, D.Swetha
    • Article Type: Research Article
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    • Pages (434-442)
    • No of Download = 39

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    Theaimofthestudy wasto prepare Simvastatin pulsatile tablets to release the drug at predetermined time after a lag period, so that drug from the formulation will be released according physiological need of the body for the effective treatment of peptic ulcer .The approach of the present study was to make a comparative evaluation among concentration of these polymers and to assess the effect of physico-chemical nature of the active ingredients on the drug release profile. The λ max of Simvastatin in 7.2 pH Phosphate buffer was scanned and found to have the maximum absorbance at 247 nm. Standard graph of Simvastatin in 7.2 pH phosphate buffer was plotted. The Bulk density and tapped density of the Controlled release tablets were found to be 0.39-0.56 and 0.44 to 0.69 respectively. The angle of repose values obtained for the Controlled release tablets ranged from 18.17 to 25.98 This indicates good flow property of the powder blend. The compressibility index values for the Simvastatin Pulsatile tablets ranged from 12.24 to 20.0 This indicates the powder blend have good flow property. The cars index values for the Simvastatin Pulsatile tablets ranged from 1.057 to 1.26 This indicates the powder blend have good flow property. In vitro drug release profiles for all Simvastatin Pulsatile tablets were carried out by using 7.2 pH phosphate buffer as dissolution medium for about 24 hrs. From the above results it was found that the release of drug from F12 formulation with Eudragit RLPO gave the better release than other Simvastatin Pulsatile tablets.

  19. To study the effect of kinesiotaping on scapular stability and upper limb function in sub-acute and chronic stroke patients – a pilot study (case series) Download Article

    Sanjukta S Khokale, Dr. Sayli Paldhikar, Dr. Snehal Ghodey
    • Article Type: Case Report
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    • Pages (443-449)
    • No of Download = 28

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    Objectives To study the effect of Kinesiotaping on functional performance of the hemiplegic upper extremity using Fugl Meyer Physical Performance Assessment Scale. Methods In this pilot study, 6 sub-acute and chronic stroke patients were selected. Kinesiotaping was applied to upper trapezius and serratus anterior muscles of the affected side for 3 days. Fugl Meyer Physical Performance Assessment Scale for the motor performance on hemiplegic upper extremity before and after the application of Kinesiotape was done. Data analysis was done on 3rd day. Results On pre post analysis, Fugl Meyer Physical Performance Assessment Scale showed a statistically significant improvement (p < 0.0001). A sample size of 6 subjects showed improvement in motor domains of shoulder, wrist and hand. Wilcoxon matched-pairs signed-ranks test was used to analyse the pre and post difference of Fugl Meyer Physical Performance Assessment Scale with results as very significant with p-value of 0.0083. Conclusion Kinesiotaping may be effective in improving functional motor performance in hemiplegic upper extremity in recovering hemiplegic patients.

  20. Carcinoma of breast with osseous metaplasia: An uncommon pathology Download Article

    Shubhangi Kachore, Pragati Karmarkar
    • Article Type: Case Report
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    • Pages (450-455)
    • No of Download = 27

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    Metaplastic breast carcinoma is a rare breast neoplasm, and metaplastic carcinoma with osseous differentiation is even rarer. It originates from a change in the differentiation of epithelial metaplastic breast tissue cells to squamous cell, spindle cell and/or mesenchymal appearance. We present a case of 49 year old woman who was diagnosed with metaplastic carcinoma of breast with osseous differentiation. This case is reported for its rarity.

  21. Effect of ballistic stretching versus PNF hold-relax stretching on hamstrings flexibility in non-athletic young adults Download Article

    Nikita Joshi, Dr. Ravinder Kaur-Mahapatra (PT), Dr. Snehal Ghodey (PT)
    • Article Type: Research Article
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    • Pages (456-462)
    • No of Download = 22

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    To assess the effect of Ballistic stretching versus PNF Hold Relax stretching on hamstrings flexibility in non-athletic young adults. Study design included pre-post control and experimental group design. Participants were 43 non-athletic healthy young adults between age groups of 20-30 years. Purposive sampling was done and the subjects were randomly allocated in 2 groups. Group I received hot pack and therapist-applied PNF stretching. This group received 3 repetitions of PNF Hold Relax in each session. Group II received hot pack and self-stretch ballistic stretching. This group received 3 exercises which were performed for 3 sets, 30 seconds each. Outcome measures included 90–90 Straight Leg Raising Test measured by Universal goniometer. Each group received stretching on 5 consecutive days. Intragroup analysis showed that both techniques were statistically extremely significant (<0.0001). The Intergroup analysis showed that difference between effectiveness of both techniques were not statistically significant bilaterally (Right- 0.0706 and Left- 0.6251). This study concluded that though there is no significant difference between PNF Hold-Relax stretching and Ballistic stretching on hamstrings flexibility in healthy young adults, both are effective treatment methods.

  22. Added effect of muscle energy technique on improving functional ability in frozen shoulder Download Article

    Ritu Shamdasani, Anjali Kulkarni, Snehal Ghodey
    • Article Type: Research Article
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    • Pages (463-469)
    • No of Download = 24

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    Background and Objectives In Frozen Shoulder patients have a painful loss of shoulder motion with development of dense adhesions, capsular thickening and capsular restrictions, especially in the dependent folds of the capsule. Muscle energy technique helps to mobilize restricted joints by stretching hypertonic muscles, capsules, ligaments, and fascia. The aim of the study is to find out the effect of MET with Conventional therapy to improve the shoulder range of motion and function in frozen shoulder. Materials and Method This experimental study was conducted among 30 participants who included both male and female symptomatic individuals from the age group of 40 to 60 years. Participants were randomly assigned into two groups of 15 each which included Conventional therapy (group A) and MET along with conventional therapy (group B) was given for 15 days. The Outcome measures were recorded pre and post 15th day of intervention using universal goniometer for shoulder Range of motion of Abduction, Internal and External Rotation and Shoulder Pain and Function Disability Scale (SPADI). Result Within group analysis showed that improved range of motion and functional disability was statistically significant in both the groups (p< 0.0001) whereas between group analysis revealed that Conventional treatment along with MET (group B) is more effective than conventional treatment in improving range of motion and function in Frozen shoulder. Conclusion Hence, it can be concluded that MET along with Conventional therapy is more effective in treatment of Frozen Shoulder.

  23. Primary Evans syndrome - case report Download Article

    Vishnu Shankar H, Jagadeesan M, Prasanna Karthik S, Kannan R, Mahendrakumar K, Halleys Kumar E, Nithyananthan P
    • Article Type: Research Article
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    • Pages (470-472)
    • No of Download = 32

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    Evans syndrome is a rare hematological disorder in which autoimmune hemolytic anemia and immune thrombocytopenia occur in the same patient. Patients usually have relapses and remissions. We report a female aged 32 years who presented with menorrhagia and purpuric rashes over her extremities. Investigations revealed thrombocytopenia and Coombs positive Autoimmune Hemolytic Anemia (AIHA) which was suggestive of Evans syndrome.

  24. Effect of pilates on pain and quality of life in females with primary dysmenorrhea Download Article

    NehaOswal, Dr. AnuradhaSutar, Dr. SnehalGhodey
    • Article Type: Case Report
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    • Pages (473-479)
    • No of Download = 29

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    Background and Aim Dysmenorrhea is a gynecological disorder which is characterized by lower abdominal pain which may irradiate to thighs and top and bottom of the spine. Primary dysmenorrhea occurs when there is no identifiable pelvic disease and tends to occur within 12 months of menarche. This study was carried out to see the effect of Pilates on pain and quality of life in females with primary dysmenorrhea Participants 40 subjects within the age group of 18-25 years with primary dysmenorrhea. Intervention Experimental group was given a structured 8 weeks (3sessions/week, 40mins/day) Pilate’s protocol and control group was observed without exercises and lifestyle modifications Outcome measure Pain intensity was determined by Numerical Rating Scale and Quality of life was assessed by HRQOL SF-36 questionnaire. Results The results showed that there was highly significant change in pain intensity in experimental group (Pre: 7.15 and Post: 3.80), whereas no significant change was seen in control group (Pre: 6.85 and Post: 6.70). Also, significant changes were seen in all the eight domains of HRQOL SF-36 in experimental group as compared to control group. Conclusion Pilates reduces the pain as well as improves the Quality of Life in females with Primary Dysmenorrhea.

  25. Added effect of proprioceptive neuromuscular facilitation on functional ability and trunk muscle endurance in chronic low back pain patients Download Article

    Sayali R. Sawant, Dr. Snehal Ghodey
    • Article Type: Research Article
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    • Pages (480-486)
    • No of Download = 18

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    Objectives The purpose of the study was to determine added effect PNF on trunk muscle endurance and functional ability using trunk muscle endurance test and Oswestry low back pain disability questionnaire. Methodology 40 subjects with Chronic mechanical low back pain were selected and were randomly allocated into experimental and control groups. Subjects were assessed on measures of trunk muscle endurance and oswstry low back pain disability questionnaire score prior to and after 3 weeks of intervention. The intervention in the experimental group included PNF (COI) with conventional treatment and control group included only conventional treatment for, 3 times/week for 3weeks. Results In the inter-group comparison conducted through arch index values, experimental group showed significant increase in trunk extensor endurance. Among intra-group comparison, both the groups showed significant increase in trunk flexion and extension endurance with significant decrease in oswetry score. Conclusion In the present study, it could be seen that PNF technique showed significant improvement in trunk extension endurance in patients with chronic mechanical low back pain. Therefore it has got an added effect in trunk extension endurance.

  26. Prescribing pattern in coronary artery disease of Indian railway hospital Download Article

    N. Sujana Priya, R. Kumanan, A.Sambasiva Rao
    • Article Type: Research Article
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    • Pages (487-513)
    • No of Download = 13

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    The objective of this study was to assess the prescribing pattern in coronary artery disease of Indian railway hospital. The prospective, interventional and follow up study was conducted in inpatient department of cardiology. Coronary artery disease patients were enrolled into the study by considering inclusion and exclusion criteria. Details of demography, treatment and other medical details were captured in patient data collection form at baseline. Medication knowledge of the patient was assessed using medication knowledge assessment questionnaire assessment questionnaire at baseline after which the patient was counselled systematically. Medication knowledge of the patient were reassessed at first follow up and second follow up followed by counselling by pharmacist. Pattern of different drugs prescribed in coronary artery disease were analyzed. 150 patients were enrolled in the study of which 78 (52%) were male patients and 72 (48%) were female patients. The male to female ratio among the patients was 3:2. The incidence of CAD was more common in male compared to female. Among 150 prescriptions analyzed anti-platelet drugs were prescribed in 149 (99.3%) patients. Out of these (n=149), a fixed dose combination (75 mg) of aspirin and clopidogrel was found to be used in 145 (96.66%) and aspirin (150 mg) and clopidogrel (75 mg) singly were used in 130 (87.24%) of the patients. Aspirin alone was used in very few patients 11 (7.38%) and in least no. of patients 9(6.04%) clopidogrel alone was used. The most commonly prescribed drug classes in coronary artery disease were antiplatelet drugs followed by antihyperlipidemics and antibiotics. This was followed by anti-anginal drugs, antihypertensives and anticoagulants. Polypharmacy (9.68 drugs per prescription) was noticed. Very few drugs were prescribed by generic name. The prescribing pattern could be improved by reducing the number of drugs per prescription and by prescribing generic drugs to reduce the economic burden of the patients.

  27. RaktawahaStrotas and its Correlation with Mulasthan as a Yakrit (Liver) Download Article

    Dr. Kavita A. Khond
    • Article Type: Research Article
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    • Pages (514-516)
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    “Srotas are the channels, which are widely spread all over the body, where circulation of the fluid occurs irresistibly and continuously. As per Ayurveda, Strotas are the important aspect of study like that of Tridosh and dhatu. Dhatus are created in the Strotas with the help of Doshas. Strotas are responsible for all the formation of new cells and tissues as well as dhatu formation in our body. All the metabolism, anabolism and catabolism are carried out in Strotasas. SushrutokataRaktavahaStrotas, the Mulasthana are Yakruta, Pliha and Raktavahinyadhamnya. It can be considered that liver and spleen along with blood vessels which are supplying blood to them which is known as portal circulation. A study was conducted on study of structural and physiological aspect of liver and correlation with RaktavahaStrotas. In this study 50 patients of liver diseases was selected, in these patients, Raktavahadushti has been recorded and it has been found that, in the study the pathology of RaktavahaStrotas causes deformity in mulasthanaYakruta. Any pathology in Raktadhatu (blood) causes disturbance in MulasthanYakrut. MulasthanaYakrut (liver) causes jaundice which is described in Ayurveda as PanduHalimak and other diseases as per described in Ayurveda.

  28. Ebola - A review of threatening epidemic Download Article

    Bhargavi Ganiwada, Attaluri Tanuja, V.S.N.Murthy, Phani Kumar Kola
    • Article Type: Review Article
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    • Pages (517-530)
    • No of Download = 29

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    Ebola, which is widely spreading epidemic, has to be considered seriously to wipe it off completely from all corners of the world. The present study helps us to augment the awareness and knowledge to healthcare providers and to strengthen the standard precautions for prophylaxis and implementation of health care facilities at all the stages. There is no risk of transmission of this disease during the incubation period. Thus, the information flourished here helps us to overview the causes, symptoms, risk factors, etc. and also the necessary precautions, diagnosis in time, treatment and safety measures to be taken to eradicate Ebola virus completely from the roots.

  29. Anti diabeic activity on home remedies Download Article

    R.Parthibarajan, R.Kumanan, S.Sudha
    • Article Type: Research Article
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    • Pages (531-557)
    • No of Download = 20

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    Diabetes is a very common disease or disorder of metabolism. It is a complex group of diseases triggered by various causes. People with diabetes have high blood glucose, also known as high blood sugar or hyperglycemia. The digestive tract breaks down carbohydrates or sugar and starches found in many foods into glucose, a form of sugar that enters the bloodstream. With the help of the hormone insulin the bodies absorbs glucose and utilizes it for producing energy. Diabetes develops when the body is unable to produce enough insulin or use insulin effectively. Insulin is made in the pancreas, an organ located behind the stomach. The Pancreas contains clusters of cells called islets; the beta cells within the islets make insulin and release it to the blood. If the beta cells don’t produce enough insulin or the body is unable to respond to insulin that is present, the glucose builds up in the blood instead of being absorbed by the cells in the body, leading to prediabetes or diabetes. Prediabetes is a condition in which the blood glucose levels or A1C levels are higher than normal, but not high enough to be diagnosed as diabetes. In diabetes the body cells lack enough energy, even though the glucose levels are very high. The increase in the blood sugar levels damages nerves and blood vessels. It also leads to complications like cardiovascular diseases, strokes, kidney problems, blindness, dental problems and amputations. High blood glucose levels also damage nerves and blood vessels.

  30. Review on surgical site infections Download Article

    G.Ramya Balaprabha, SD Sandhya, K.Pragna, Ch.Madhav, Sushanth krDas, DR.K.Abbulu
    • Article Type: Review Article
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    • Pages (558-569)
    • No of Download = 14

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    Surgical site infections (SSI) are the wound infections which occur within a time period of 30days in superficial incisional SSI and can extend to 1year after surgery in case of prosthetic implantation (deep incisional SSI) or can occur in traumatized organ/space like pleural space, peritoneal space, joint space etc. Surgical Site Infections can be classified into different categories depending upon the site and extent of infections. They are incisional SSI and organ SSI where incisional SSI is further subdivided into Superficial SSI and deep incisional SSI. Staphylococcus aureus and Coagulase negative staphylococci is the primary cause of infection in SSI. Wound swabbing and serum examinations are the used diagnostic technique for SSI diagnosis. National Nosocomial Infections Surveillan (NNIS) is the common tool to predict risk of SSI and other ways of assessing risk are ASEPSIS and Southamptom scoring system. With increasing risk of SSIs, wound can be classified into four different classes. They are clean, contaminated, clean-contaminated and dirty wounds. The Recommended antibiotic for surgical site infection is first generation cephalosporin’s particularly Cefazolin.

  31. Effect of rhythmic auditory stimulation on cadence and gait speed in spastic cerebral palsy Download Article

    Dr. Madhushree Sawant, Dr. Priya Chitre, Dr. Snehal Ghodey
    • Article Type: Research Article
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    • Pages (570-580)
    • No of Download = 24

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    The purpose of this research was to assess whether any improvement is seen in Cadence and Gait speed by giving Gait training with Rhythmic Auditory Stimulation (RAS) along with general mobility strengthening exercises in spastic cerebral palsy (CP). It is seen that spastic CP have impaired internal cueing, co-contraction of agonist with antagonist instead of normal reciprocal relaxation persists, the chain of muscles used for movements have abnormal firing & abnormal gait pattern with affected gait parameters such as reduced cadence and gait speed, reduced step and stride length, and RAS has an effect on improving the internal cueing which may in turn help improve the affected gait parameters. In this study 31 subjects were selected all of them were given conventional physiotherapy exercises & gait training for 20 minutes individually; 16 were given gait training with RAS(experimental) & 15 were given conventional gait training without RAS(conventional). It was seen that the experimental group had a much more efficient and significant improvement in cadence & gait speed as compared to the conventional group, suggestive of RAS providing an efficient added effect over conventional physiotherapy exercises in spastic CP.

  32. Anti oxidant and hepatic enzyme changes in Kanakalinga karpoorati mezhugu, treated Experimental hypothyroid disorder Download Article

    Elango.V, Jeyavenkatesh J
    • Article Type: Research Article
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    • Pages (581-585)
    • No of Download = 26

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    Many metal and mineral raw drugs are prepared in Siddha medicine as Mezhugu, Pathangam, Parpam, Chenduram, Kalangu, Kattu, Urukku and Chunnams and need global standards. A detailed in-vivo and in-vitro studies of KLK mezhugu for its quality, efficacy other indications should be ascertained using modern parameters. Chemical nature of the KLK mezhugu depends upon the purification methods, materials mixed, quantity, quality of heat and flame, type of fuel, duration of heat, periodicity of grinding, size of the particle and solubility, assimilation and absorption in the alimentary tract are some of important factors to be studied. Male albino rats were used for this present thyro-toxicity study. Animals were provided with normal rats feed and normal water ad libitum. Methimazole was given to induce hypothyroidism and KLK mezhugu in water suspension was used a test drug. Animals were fasted overnight, anaesthetized with ether and sacrificed by cervical decapitation, blood was drawn and the serum was separated for biochemical analysis. Thyroid protective activity was done by assessing the significant changes in body weight, Serum T3 triiodothyronine, T4 thyroxine, TSH, Albumin, Cholesterol, Triglycerides, Lipid peroxide, Transaminases, Acid phosphotases were estimated and the Mean values standard were calculated for all the values carried out. The result of this study shows the significant protect activity in thyroid necrosis against methimazole induced thyroid-toxicity.

  33. Dry eye following cataract surgery Download Article

    Divya N, Xavier Jayaseelan.C
    • Article Type: Research Article
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    • Pages (586-591)
    • No of Download = 16

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    Aim To Evaluate Dry Eye changes after small incision cataract surgery and Phacoemulsification. Materials and Methods This is a prospective study with 100 Uncomplicated Cataract patients between age group above 45-75years undergoing cataract surgery were taken for the study and dry eye changes were analyzed at 7,30 and 90 days after SICS and PHACOEMULSIFICATION including clear corneal incision and scleral incision by TBUT and Schirmers test. Results After 90 days postoperatively 12% of patients proved dry eye changes with reduced TBUT, 14% patients showed dry eye symptoms which were more marked in patients who underwent phacoemulsification. Conclusion 3 months after cataract surgery (SICS and PHACOEMULSIFICATION) 14% of patients showed dry eye symptoms,12% showed decrease in TBUT,11% had lower value of schirmer1 and 8% had lower value of schirmer with anesthesia. Symptoms and signs of dry eye occurred as early as 7th post operative day after cataract surgery and the severity pattern improved over time. So evaluation of patients of both before and after cataract surgery either small incision cataract surgery or phacoemulsification should be done to prevent further damage to the ocular surface and able to manage the patients promptly and effectively so the patients will not have poor quality of life and vision due to dry eye syndrome.

  34. Immediate added effects of pain releasing phenomenon on DE Quervains tenosynovitis pain – a mulligan concept technique Download Article

    Dr.Rajashree Lad, Dr. Varoon Jaiswal, Dr. Sneha Ghuman, Dr. Snehal Ghodey
    • Article Type: Research Article
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    • Pages (592-596)
    • No of Download = 16

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    Objectives The purpose of the study was to determine was to determine the added effects of PRP in De quervain’s tenosynovitis using Numerical Pain Rating Scale and Patient Specific Functional Scale. Methodology 32 subjects with diagnosed De Quervain’s tenosynovitis were selected and were randomly allocated into control and experimental groups. Subjects were assessed on measures of pain, ROM and functional status prior to and immediately after intervention. The intervention in the control group included Ultrasound and in experimental group included Pain Releasing Phenomenon (PRP) with conventional treatment. Results The experimental group showed significant decrease in pain and improved functional status. Comparison revealed, there was reduced pain and improved functional status in both the groups but was remarked in experimental group. Conclusion In the present study,it could be seen that PRP technique showed significant improvement in pain and improved functional status in patients with De Quervain’s tenosynovitis.

  35. Purple urine bag syndrome Download Article

    Srujith Chandrakanti, Lavanyasri Ilampudi, Jagadeesan Mohanan, Halleys Kumar Elumalai, Prasanna Karthik Suthakaran, Kannan Rajendran, Mageshkumar Sivanesan
    • Article Type: Case Report
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    • Pages (597-599)
    • No of Download = 11

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    Purple bag syndrome (PUBS) is a rare condition in which urine color appears purple in the urobag. Purple coloured urine occurs due to the accumulation of indigo and indirubin, which are the end products of tryptophan metabolism due to the action of sulfatases and phosphatases formed by bacteria like Providencia, Citrobacter, Enterobacter, Klebsiella etc. We present this interesting phenomenon of purple urine in a female who was on prolonged urinary catheterization. The urine culture was positive for Klebsiella oxytoca.

  36. A study of maternal and fetal outcome in postdated pregnancy Download Article

    Padmalatha Dakshnamurthy, Srimathi Jagannathan, Nidhi Sharma, Kannan Rajendran
    • Article Type: Research Article
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    • Pages (600-606)
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    Objective To assess the whether the elective induction of labor at 41 weeks is associated with lower caesarean section rates as compared to elective induction of labor at 40 weeks in a postdated pregnancy. Perinatal morbidity and mortality were also compared at 40 weeks and 41 weeks of gestation. Participants Labor was induced in 50 cases of postdated pregnant women at 41 weeks. 50 cases of post-dated women with labor induction at 40 weeks were taken as controls. Main outcome measures The primary outcome was assessed as the incidence of microsomal/low birth weight, color of liquor, incidence of MAS, NICU admission rate, APGAR score less than 7 at 5 minutes. Secondary outcome was incidence of instrumental delivery (vacuum, forceps) and LSCS. Results There was a minimal increase in the incidence of babies with increased birth weight (>3.6kg) in the study group (7% vs. 4%). The meconium staining of liquor is higher in the study group (65% vs. 35%). Though there was a higher rate of meconium staining of liquor and the need for amnioinfusion in the study group, the NICU admissions, Apgar of <7 at 5 minutes and the number of neonatal deaths were the same in both the groups. The LSCS rates are low (16% Vs 28%) in the study group. The rates of instrumental delivery (12%) in the study group is less compared to the control group (26%) Conclusion NICU admissions, APGAR score at 5 minutes and neonatal mortality is almost the same in both study and control group. Labor Induction at 41 weeks is more likely to culminate in a normal delivery as the Bishop score improves. Induction of labor in an uncomplicated low risk pregnancy at 41+ weeks of gestation is associated with reduced caesarean section rates with no adverse effect on neonatal outcome.

  37. Correlation between neck pain and upper limb dysfunction in non-specific neck pain patients Download Article

    Dr Prachita Walankar, Disha Gandhi
    • Article Type: Research Article
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    • Pages (607-610)
    • No of Download = 14

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    Background & Aim Non-specific neck pain is defined as simple neck pain without any specific underlying disease that leads to pain. The aim of the present study was to find relation between neck pain and upper limb disability in nonspecific neck pain patients. Methodology Type of study is a cross-sectional study with purposive sampling method. 80 subjects in the age group of 18 – 40 years diagnosed with nonspecific neck pain were recruited. Subjects with cervical radiculopathy or existing upper limb pathology were excluded from the study. The Visual Analogue scale (VAS) was used to assess neck pain and Neck Disability Index (NDI) was used to measure the effect of neck pain on daily activities. The upper limb disability was measured using Disabilities of the Arm, Shoulder and Hand (DASH) questionnaire. Results The results showed a significant positive correlation between VAS and DASH (r = 0.54, p= 0.000). Also, a significant positive correlation was found between NDI and DASH (r = 0.75, p= 0.000). Conclusion These findings provide evidence that there is relation between neck pain and upper limb dysfunction in non-specific neck pain disorders.

  38. The correlation between serum homocysteine levels and hypothyroidism: A 1-year case control study Download Article

    Dr. Anjali R. Metgudmath, Dr. U. M. Vaishak
    • Article Type: Research Article
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    • Pages (611-615)
    • No of Download = 17

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    Background Thyroid hormones have significant effects on lipid metabolism and homocysteine levels. Decrease in thyroid hormone levels may alter the homeostasis of lipid metabolism and homocysteine levels. Objectives To study the incidence of hyperhomocysteinemia and hypercholesterolemia in patients with hypothyroidism, and to find out the correlation of homocysteine with cholesterol levels, thyroid hormones and thyroid-stimulating hormone (TSH) in newly detected hypothyroid patients. Methods In this prospective case-control study, 30 hypothyroid patients (case group) and 30 euthyroid controls were included. Patients with a TSH level >4.78 mIU/mL were considered in the case group and those with TSH level <4.78 mIU/mL were included in the control group. Cases and controls were matched on the basis of age, sex, and body mass index. Levels of TSH, free T3 andT4, fasting serum homocysteine, and total cholesterol were investigated in both case and control groups. The data were statistically analysed with Independent t-test and Pearson’s correlation method by SPSS 20.0. Results Compared to controls, significant increase in serum homocysteine levels was observed in in hypothyroid group (P = 0.0064). Serum total cholesterol levels were significantly higher in hypothyroid group when compared with control (P = 0.0066). Correlation of serum homocysteine levels with the levels of TSH, free T3 and T4, and serum cholesterol levels were statistically not significant in both hypothyroid group. Conclusion We observed a significant increase in levels of homocysteine and total cholesterol levels in hypothyroid group when compared with control. Hyperhomocysteinemia and increased cholesterol levels can contribute to cardiovascular risks. We recommend screening of serum homocysteine levels in hypothyroid patients to detect atherosclerosis and cardiovascular diseases.

  39. Clinical evaluation of the virechana therapy along with an indigenous compound in the management of tamak shwasa (bronchial asthma) Download Article

    Dr. Poonam Sharma and Prof. (Dr.) O. P. Gupta
    • Article Type: Research Article
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    • Pages (616-619)
    • No of Download = 12

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    Tamak Shwas is a disease of respiratory system where the patient feels difficulty in breathing and it can be correlated to Bronchial Asthma in modern parlance. The disease Shwas as described in Ayurveda is of 5 varieties out of which 3 types of Shwas are stated to be incurable, while one of them doesn’t need any treatment only rest is sufficient, whereas the “Tamak Shwas” has an important place in relation to chikitsa i.e. treatment and management as it is termed as Yapya, i.e. palliative. Tamak Shwas i.e. Bronchial Asthma can be managed with proper therapy. In this context Virechana plays an important role in its management as it is stated “Tamaketu Virechanam” in context to the treatment of Tamak Shwasa. A Study has been carried out to evaluate the effect of Virechana Therapy along with an Indigenous preparation in the management of Tamak Shwasa (Bronchial Asthma). For this an indigenous Compound drug (Shirish, Guduchi and Vasaka) was prepared in the form of Ghan Vati and Virechana Dravya consisting of Guduchi Satva, Triphala Churna and Eranda Taila was advocated in two different groups each consisting of 20 patients. Group A was given only trial drug in a dose of 1gm (two tablets) thrice daily with warm water while patients in Group B were advised to take Virechana Therapy for 7 days prior to trial drug therapy. The effect was compared and found to be encouraging with fewer side effects.

  40. To study the efficacy of an indigenous compound in the management of sthaulya with special reference to obesity syndrome Download Article

    Dr. Vivek Kumar Sharma and Prof. (Dr.) O. P. Gupta
    • Article Type: Research Article
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    • Pages (620-624)
    • No of Download = 12

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    The Disease Sthaulya has been mentioned since the vedic period by numerous authors. It is also one of the Kapha Nanatmaja Vyadhis and Meda Dhatu dusti along with Mandagni are stated to be the root cause. The causes, sign and symptoms along with its management are directly correlated to Obesity Syndrome in the present era. Obesity is a medical condition in which excess body fat has accumulated to the extent that it may have a negative effect on health and it is commonly termed as BMI (Body mass Index) of 30 kg/m2 or higher. Worldwide obesity has more than doubled since 1980. Due to its increased global prevalence a term GLOBESITY is being coined. It is one of the leading preventable causes of death worldwide. There are several lipolytic and hunger suppressive therapies available in modern medicine, still due to their allied complications & side effects on overall health, search for an alternative medicine is the need of the day which should be not only cost effective but also have fewer side effects. Keeping in view of the above points a clinical trial was conducted to evaluate the efficacy of an indigenous compound drug in the proper management of Sthaulya (Obesity Syndrome). The poly herbal compound drug was composed of Trikatu, Triphala and Guggulu in 1:2:3 proportions. Trial was conducted on 40 patients and the effect was compared before and after the treatment. Result was found to be encouraging.

  41. Synthesis and anti-inflammatory activity of some pyrazolone derivatives Download Article

    Vanita Marvaniya, Hiren Marvaniya, Dr.Neha Tiwari, Seju Patel, Rajwinder Kaur
    • Article Type: Research Article
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    • Pages (625-631)
    • No of Download = 16

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    Pyrazolone is a ketone derivative of pyrazole having anti inflammatory, analgesic, antipyretic effect. Pyrazolone is a five- membered lactam ring compound contacting two nitrogen and ketone in the same molecule. Pyrazolones are well established in literature as important biologically active heterocyclic compounds. Pyrazolone in the class of nonsteroidal anti inflammatory agents used in the treatment of arthritis and other musculoskeletal and joint disorder. The objective of present study was, to synthesize the pyrazolone derivatives and to evaluate for their anti-inflammatory activity. Method In the present work, a series of some pyrazolone derivatives (2a-j) were synthesized, characterized by TLC, Melting point determination, IR, NMR and Mass spectra and evaluated for their anti-inflammatory activity by invitro using inhibition of albumin denaturation technique method. Result & Conclusion 2a,2b,2d, Compounds showed significant anti-inflammatory activity as compared to other drug. Aspirin used as a standard drug.

  42. Retromolar trigone metastasis from operated case of invasive ductal carcinoma of the breast: a rare entity Download Article

    Dr. Raj Nagarkar, Dr. Shrikant Vanjari, Dr. Hrushikesh S. Kolhe, Dr. Shirshendu Roy, Dr. Aditya Adhav, Dr.Yash Devckar
    • Article Type: Case Report
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    • Pages (632-635)
    • No of Download = 15

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    Oral malignant metastases are a relatively rare finding considering the incidence of metastatic tumors in the body. Oral cavity is a rare site of metastasis from the breast. Because of their rarity and atypical clinical and radiographic appearance, metastatic lesions are considered a diagnostic challenge. We describe case report of an operated case of infiltrating ductal carcinoma of breast metastasizing to retromolar trigone region.

  43. A review article for herbal drugs as anxiolytic activity Download Article

    Mrs. Rajwinder Kaur, Dr. Neha Tiwari , Ms. Seju Patel, Mrs. Vanita Marvaniya
    • Article Type: Review Article
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    • Pages (636-647)
    • No of Download = 14

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    Anxiety is an emotional and physiological response to known or unknown causes that may range from a normal reaction to extreme dysfunction (indicative of an anxiety disorder), affect decision-making, adherence to treatment, and impair functioning, affect quality of life. There are number of herbs used in the anxiolytic activity i.e. Bacopa monnieri linn., Casimiroa edulis, Citrus aurantium Linn., Emblica officinalis, Ginkgo biloba L., Hypericum perforatum linn., Magnolia officinalis, Piper methysticum, Withania sominifera linn., Zingiber officinale etc. Compared to pharmaceutical drugs, herbs are safer and more digestible, effective and economical. As an effective treatment for various health conditions, herbs are great alternatives to pharmaceutical drugs. Unlike pharmaceutical drugs, herbs promote an improvement in overall health when combined with a raw-vegan diet and regular exercise. The leaves, roots, stems of different plants are sources of vitamin c, minerals, amino acid that can be helpful in case of CNS disorders. In review of study, we studied that anxiolytic activities of different extracts (ethanolic and aqueous extracts) of different plants in mice/rat, at the different doses (30, 100, 300 mg/ kg) have shown significant results as a Anxiolytic activity (neurotransmitter balance) using LDM , EPM parameters respectively .

  44. Development and validation of q-absorbance ratio method for simultaneous estimation of arterolane maleate and piperaquine phosphate in pharmaceutical dosage form Download Article

    Seju D Patel, Dr Neha Tiwari, Mrs Vanita Marvaniya
    • Article Type: Research Article
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    • Pages (648-656)
    • No of Download = 10

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    New Spectrophotometric Q-Absorbance Ratio method has been developed for the simultaneous estimation of Arterolane maleate and Piperaquine phosphate in tablet dosage form. UV spectrophotometric method, methanol was used as a solvent. Objective To develop simple, accurate, linearity, precision and reproducible UV Spectroscopic method for Arterolane maleate and Piperaquine phosphate in routine analysis. Method Aliquots of stock solution were further diluted with methanol to get working solution of 2.5-8.75μg/ml for Arterolane maleate and 12.5-43.5 μg/ml for Piperaquine phosphate working standards were scanned between 200 - 400 nm which shows the maximum absorbance at 276nm. Results The Iso -absorptive point was found to be 242 nm. Calibration curve were linear over a concentration range of 2.5-8.75 μg/ml for Arterolane maleate and 12.5- 43.5 μg/ml for Piperaquine phosphate. Accuracy of method was determined through recovery studies which were found 99.36%-101.22% for Arterolane maleate and 99.46%- 100.80% for Piperaquine phosphate. Method was found to be reproducible with relative standard deviation for intra- day and inter-day precision to be < 1.5%. Conclusion This method was found to be simple, Accurate, precise and reproducible. The proposed UV method can be applicable for the simultaneous estimation of both the drugs in tablet dosage form.

  45. Acclerated orthodontics- A review article Download Article

    Dr Jeevan M Khatri, Dr Ritika R Pande ,Dr Parikshit Agarwal
    • Article Type: Review Article
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    • Pages (657-662)
    • No of Download = 12

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    Prolonged treatment duration is one of the main deterants in orthodontics. Lengthy orthodontic treatment prompts many patients, especially adults, to either avoid treatment or to seek shorter alternative solutions with compromised results. Therefore, the treatment modalities that decrease treatment time without compromising the treatment outcome is an active area of research in orthodontics today. Various methods have been introduced to enhance the rate of tooth movement which include surgical methods, mechanical stimulation methods and some drugs. These methods have successfully proven to reduce treatment times by up to 70%. This review encapsulates the current knowledge on the molecular mechanisms underlying accelerated orthodontic tooth movement, and the clinical and experimental methods that accelerate orthodontic tooth movement.

  46. Drug utilization pattern of anti-diabetic drugs among type 2 diabetes mellitus patients – a prospective study Download Article

    Thushara. C, Sreeja. P A, Radhakrishnan. A P
    • Article Type: Research Article
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    • Pages (663-669)
    • No of Download = 10

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    Introduction Diabetes mellitus (DM) is emerging as major health problem. There has been worldwide increase in prevalence of DM, especially in developing countries. With this increased prevalence of diabetes, drug utilization study of antidiabetic drugs is very useful from health care viewpoint. Aim The aim of study was to investigate the drug utilization pattern in type-2 diabetic patients. Methods A prospective observational study was carried out in Palakkad Diabetic Centre, Palakkad, for 6 months. Patients with type-2 diabetes and on drug therapy with or without co morbidities and complications were included. Patients’ socio-demographic and clinical data were noted in a pre-designed proforma. Data was analyzed by using SPSS version 16 and Excel 2007. Result Total 428 patient were enrolled with Mean± SD age 57.72± 10.8, were females are more prevalent (52%) and 77% had family history. Hypertension (26%) was most common co-morbid disease followed by dyslipidemia (21%). Totally 32% of patients were on Monotherapy and Metformin was commonly prescribed. In combination therapy, Glimepiride and Metformin (77%) were mostly consumed followed by Glibenclamide and Metformin (12%) there was no evidence of Polypharmacy. Conclusion Metformin was the most commonly used drug. The prescribing trend also appears to be moving towards combination therapy particularly two drug therapy. All insulin preparations were human insulin. . Incidence of diabetes has been found higher in female as compared to male and majority of the patients develop diabetes in the most productive years of their life .This study contributes to the growing body of literature on drug utilization research.

  47. Prescription monitoring & the pattern of prescribing drugs in pediatric patients done in a periodic study Download Article

    Pradeep Kumar Ankishetti, Abhinav Kulkarni, Gande Naresh, D. Nandini, Baddam Mounika, Srikanth Sandanala, Shivkumar Shete
    • Article Type: Research Article
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    • Pages (670-677)
    • No of Download = 15

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    Pediatric patients, defined as those younger than 18 years. Factors in pediatric patients, including the limitations of commercially available dosage formulations, the unexpected administering of medicines, the general inadequacy of clinical pharmacology training, the shortage of information about drug use in children all these add to the difficulties faced by the practitioner, hence one should prescribe judiciously, carefully select the safest dosage regimen available. Considering the above facts the present study was designed to monitor the prescription and its outcomes in pediatric patients. The study was conducted at pediatric departments in a government hospital at ibrahimpatnam, during the study period of 6 months and a total of 268 cases were collected, the data was collected and analyzed. In the study majority of the age groups included were in the age groups of 5-12 yrs (42.10%) ,1-5 yrs (26.10%),0-1 yr(16.20%) ,12-18 yrs (15.60%).The gender distribution in the study included 146 male patients (54.5%) and 122 female patients (45.5%).The disease prevalence in the following study concluded that the highest occurrence of the diseases in their ascending order showed: U RTI’s(46.60%), ACUTE FEBRILE ILLNESS(25.70%), followed by DIARRHOEA(5.90%). The standard treatment for upper RTI: Chlorpheniramine maleate + Paracetamol + Phenylephrine.

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